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| 1 | Rifaximin Prevents Intestinal Barrier Dysfunction and Alleviates Liver Injury in MCT-induced HSOS Mice显示文摘Objective Rifaximin is an effective component of treatment strategies for liver and intestinal diseases.However,the efficacy of rifaximin in hepatic sinusoidal obstruction syndrome(HSOS)has not been explored.The present study aimed to investigate the efficacy and mechanism of rifaximin in HSOS.Methods An HSOS model was established in mice through the administration of monocrotaline(MCT,800 mg/kg),and part of the HSOS mice were intragastrically administered with rifaximin.Then,the efficacy of rifaximin in HSOS was evaluated based on the liver pathological findings,liver proinflammatory cytokines,and alanine aminotransferase and aspartate aminotransferase levels.The Ussing chamber was used to evaluate the intestinal permeability,and tight junction(TJ)proteins were measured by Western blotting and real-time polymerase chain reaction to evaluate the intestinal barrier integrity.Then,the serum proinflammatory cytokine levels were evaluated by enzyme-linked immunosorbent assay.Afterwards,an in vitro experiment was performed to determine the relationship between rifaximin and TJ proteins.Results Rifaximin effectively alleviated the MCT-induced HSOS liver injury,suppressed the expression of liver proinflammatory cytokines,and reduced the serum levels of tumor necrosis factor-alpha and interleukin-6.Furthermore,rifaximin reduced the intestinal permeability,improved the intestinal barrier integrity,and promoted the expression of TJ proteins.Conclusion The results revealed that the intestinal barrier integrity was destroyed in MCT-induced HSOS.The significant alleviation of MCT-induced HSOS induced by rifaximin might be correlated to the repairment of intestinal barrier integrity via the regulation of the TJ protein expression. | Yan-yun SHU Li-lin HU Ling YANG Hui-kuan CHU Jin YE Yu JIN | 2023 | Current Medical Science2023，43，6： | 0 |
| 2 | TIPS治疗27例肝窦阻塞综合征患者近、中期疗效评价显示文摘目的:评价经颈静脉肝内门腔静脉分流术(TIPS)治疗肝窦阻塞综合征(HSOS)的近、中期疗效。方法:回顾性分析2018年7月至2020年7月我中心收治的27例HSOS的患者,均行TIPS治疗,观察门静脉压力(PVP)、门静脉压力梯度(PPG)及肝功能变化,从而进行疗效评价。手术前后的计量资料比较采用配对样本t检验,计数资料采用χ2检验,取P<0.05具有统计学意义。结果:27例HSOS患者TIPS术后PVP由分流前的(4.41±0.18)kPa降至分流后的(2.69±0.11)kPa(t=82.41,P<0.001),PPG由分流前(3.23±0.18)kPa降至分流后的(1.46±0.23)kPa(t=32.41,P<0.001),差异均有统计学意义。术后肝功能较术前明显好转。术后随访24个月,3例发生支架再狭窄,经球囊扩张后再通。3例发生肝性脑病,经药物治疗后好转。1例行肝移植。结论:TIPS治疗HSOS近、中期疗效肯定,并可为肝移植患者提供了等待肝源的时间。 | 王磊 张裕 王修琪 岳振东 范振华 吴一凡 刘福全 董健 张珂 蒋力 丁惠国 张月宁 | 2023 | 中华肝脏病杂志2023，31，8： | 0 |
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