|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 原发性胆汁性肝硬化的研究进展显示文摘 | 李晓永 刘爱东 张岩明 张川 赵晓亮 李国栋 | 2007 | 现代中西医结合杂志2007，16，31： | 11 |
| 2 | Genetic association of cytokines polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese显示文摘AIM: To characterize gene polymorphism of several cytokine gene in-patients with AIH and PBC and to analyze the difference of the polymorphism distribution between Chinese patients and healthy controls.METHODS: The study population consisted of 62 patients with AIH, and 77 patients with PBC. The genetic profile of four cytokines was analyzed by restriction fragmentlength polymorphism after specific PCR amplification (PCR-RFLP) or sequence-specific primers PCR (SSP-PCR). The analyzed gene polymorphism included interleukin-1 (IL-1) (at position +3 953 and IL-1RN intron 2), IL-6 (atposition -174), IL-10 promoter (at position -1 082, -819, and -592). The control group consisted of 160 healthyblood donors.RESULTS: The majority of Chinese people including patients and healthy controls exhibited IL-1B 1,1genotype, and there was no significant difference in AIH, PBC patients and controls. There were highly statistically significant differences in the distribution of the IL-1RN gene polymorphism between the patients with PBCcompared with controls. The frequency of IL-1RN 1,1was significantly higher (90.9% vs 79.4%, P = 0.03)and the frequency of IL-1RN 1,2 was significantly lower in PBC patients (6.5% vs 17.5%, P = 0.01). No statistical difference was observed between AIH patients and controls. All of the 160 healthy controls and 62 cases of AIH patients exhibited IL-6-174GG genotype, and there were four cases, which expressed IL-6-174GC genotype in 77 cases of PBC patients. The frequency of IL-6-174GC was markedly significantly higher in PBC patients compared with controls (5.2% vs 0%, P = 0.004). No statistically significant difference was found in the distribution of IL-10 promoter genotype in AIH and PBC patients compared with controls. CONCLUSION: The polymorphisms of IL-1RN and IL-6 -174G/C appear to be associated with PBC in Chinese patients. | Lie-YingFan xiao-QingTu TU,YeZhu ThomasPfeiffer RalphFeltens WinfriedStoecker Ren-QianZhong | 2005 | World Journal of Gastroenterology2005，11，18： | 8 |
| 3 | 自身免疫性肝炎的病因和发病机理显示文摘 | 仲人前 屠小卿 | 2004 | 临床肝胆病杂志2004，20，5： | 8 |
| 4 | 原发性胆汁性肝硬化发病机制研究进展显示文摘原发性胆汁性肝硬化(primary biliary cirrhosis, PBC)的病因不清,国内外学者从多个角度入手对其发病机制进行了深入研究并提出了多个假设,取得了较大进展.PBC患者的家庭成员有较高的患病风险,且其一级亲属多伴有其他自身免疫性疾病;PBC与HLA Ⅱ型抗原关系较密切,但欧美各国与中国研究结果存在差异,说明PBC的遗传学与流行病学可能与地理分布有关;非HLA遗传因素单核苷酸多态性 (SNPs)在CTLA-4、IL、维生素D及细胞色素 P450等方面的研究都取得了不同进展;PBC易感性还可能与X连锁基因相关;近期利用重组丙酮酸脱氢酶复合物E2亚单位(PDC-E2)特异性二聚体IgA单克隆抗体(mAbs)杆状病毒表达系统对AMA进行的研究阐述了IgA在PBC 患者胆管上皮细胞(BECs)损伤中的作用,并提出了新的假设.对Sp 100的研究发现其对抗原始内皮细胞血管生成中的作用,与PBC的发病存在一定关系.近来不断有新的物质被鉴定与 PBC发病相关. | 赵臣 夏薇 李永哲 | 2006 | 世界华人消化杂志2006，14，7： | 5 |
| 5 | 83例原发性胆汁性肝硬化的临床分析显示文摘目的探讨原发性胆汁性肝硬化(PBC)的临床特点及肝脏组织学病理特征。方法回顾性分析83例PBC患者的病例资料。结果 83例PBC患者男女比例约为7︰76。临床表现依次为乏力、纳差、黄疸、脾脏肿大、腹水、皮肤瘙痒、干燥综合征及肝脏肿大。血清碱性磷酸酶(ALP)和γ-谷氨酰转肽酶(GGT)水平分别为(330.58±255.03)U/L和(255.58±234.65)U/L。抗线粒体抗体(AMA)和抗-线粒体抗体M2亚型(AMA-M2)阳性率分别为88%和71.1%。21例PBC患者肝组织病理检查提示小胆管改变最为突出。Ⅰ、Ⅱ期和Ⅲ、Ⅳ期两组患者病程及总胆红素水平差异有统计学意义(P<0.05)。结论 PBC好发于女性,临床表现缺乏特异性,血清ALP及GGT水平明显升高,自身抗体AMA和AMA-M2阳性为主要特征,病程和总胆红素水平与肝组织学进展有关。 | 肖琳 张韬 肖钧刚 沙尼亚 刘浩 鲁晓擘 张跃新 | 2010 | 中国肝脏病杂志(电子版)2010，2，2： | 4 |
| 6 | AMA/AMA-M2阴性原发性胆汁性肝硬化患者的临床及病理特征显示文摘目的:通过探讨抗线粒体抗体(anti-mitochondrial antibody,AMA)/AMA-M2阴性原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)患者的临床表现及肝脏组织学病理特征,提高对PBC的认识和诊断水平.方法:回顾性分析101例PBC患者的临床表现、生物化学、免疫学及病理学资料.比较50例AMA/AMA-M2阴性和51例AMA/AMA-M2阳性PBC患者的临床和病理学特征.结果:101例PBC患者中,男女比例为1.1∶9,平均年龄为48.52岁±8.99岁,临床表现为乏力(30.7%)、黄疸(29.7%)、皮肤瘙痒(19.8%)、口干(12.9%)、眼干(7.9%)、肝区疼痛(7.9%)、脂黄瘤(6.9%)、纳差(5.9%)、腹胀(1.98%)等.AMA/AMA-M2阴性PBC和AMA/AMA-M2阳性PBC患者的临床表现、血常规[白细胞(white blood cells,WBC)、血红蛋白(hemoglobin,Hb)、红细胞(red blood cells,RBC)、血小板(platelet,PLT)]、生化指标[门冬氨酸氨基转氨酶(aspartate aminotransaminase,AST)、丙氨酸氨基转氨酶(alanine aminotransferase,ALT)、AST/ALT、碱性磷酸酶(alkaline phosphatase,ALP)、-谷氨酰胺肽酶(glutamine peptide enzyme,GGT)、总胆红素(total bilirubin,TBIL)、总蛋白(total protein,TP)、白蛋白(albumin,ALB)、甘油三酯(triglycerides,TG)、总胆固醇(total cholesterol,TC)]、凝血指标[凝血酶原活动度(prothrombin activityprothrombin time activity,PTA)、国际标准化比值(international normalized ratio,INR)]、C3、C4、影像学和肝脏组织学表现上差异均无统计学意义.AMA/AMA-M2阳性PBC组与AMA/AMA-M2阴性PBC组比较,-球蛋白、IgG、IgM差异具有统计学意义(F=0.019,Z值分别为0.028,0.012,均P<0.05).结论:AMA/AMA-M2阴性的PBC患者临床表现缺乏特异性,AMA/AMA-M2阳性PBC患者与AMA/AMA-M2阴性PBC患者免疫状态可能存在差异.肝脏组织病理学检查仍然是诊断AMA/AMA-M2阴性PBC的金标准. | 刘卫英 肖琳 银皓 詹欣宇 张泽高 鲁晓擘 张跃新 | 2013 | 世界华人消化杂志2013，21，34： | 4 |
| 7 | 原发性胆汁性肝硬化研究新进展显示文摘原发性胆汁性肝硬化(Primary Biliary Cirrhosos,PBC)是一种累及肝小叶和间隔胆管的慢性肝病,其特征为胆管呈进行性炎症破坏,伴门脉周围炎症,继而肝纤维化,最后演变为肝硬化。除非进行有效治疗或肝移植,门脉高压和终末期肝病的其他并发症将最终导致患者死亡。实际上PBC是一个不恰当的名称,在疾病早期没有肝硬化。 | 韩荔芬 林春 | 2003 | 中西医结合肝病杂志2003，13，S1： | 4 |
| 8 | Association of Estrogen Receptor Gene Polymorphisms and Primary Biliary Cirrhosis in a Chinese Population: A Case- Control Study显示文摘 | Liu Yang Hong Zhang Yan-Fang Jiang Qing-Long Jin Peng Zhang Xu Li Pu-Jun Gao Jun-Qi Niu | 2015 | Chinese Medical Journal2015，，22： | 4 |
| 9 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 10 | Association of polymorphisms in non-classic MHC genes with susceptibility to autoimmune hepatitis显示文摘BACKGROUND:Autoimmune hepatitis is a chronic,generally progressive inflammatory disorder of the liver,of which the cause is unclear.It was demonstrated that genetic factors are involved in its pathogenesis.Previous studies showed that human leukocyte antigen in the major histocompatibility complex(MHC) is associated with susceptibility to autoimmune hepatitis.Current genome scanning studies suggest that genes outside the MHC also play a critical role in autoimmune disorders.This article focuses on our current understanding of the polymorphisms of these genes and their roles in the pathogenesis of autoimmune hepatitis.DATA SOURCES:Studies were identified by searching MEDLINE and PubMed for articles using the keywords autoimmune hepatitis,polymorphism,CTLA-4,Fas,TNF-α TGF-β1,TBX21 and VDR up to May 2011.Additional papers were identified by a manual search of the references from key articles.RESULTS:According to the case-control studies on genetic polymorphisms,at least six genes(CTLA-4,Fas,TNF-α TGF-β1,TBX21 and VDR) are involved in autoimmune hepatitis besides HLA.So far,there has been no agreement about gene susceptibility and the actual clinical significance of these genes is still controversial.CONCLUSION:Studies on gene polymorphisms outside the MHC and knowledge of genetic predispositions for autoimmune hepatitis may not only elucidate pathogenic mechanisms,but also provide new targets for therapy in the future. | Jie Tang,Cheng Zhou,Zhi-Jun Zhang and Shu-Sen Zheng Hangzhou,China Key Laboratory of Combined Multi-organ Trans- plantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery , and State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 2 |
| 11 | 非酒精性脂肪肝患者肿瘤坏死因子-α基因多态性研究显示文摘目的:了解非酒精性脂肪肝(NAFLD)患者中肿瘤坏死因子 α(TNFα)启动子基因多态性在广东汉 族人群的分布及其与疾病的相关性。方法:用聚合酶链反应 限制性片段长度多态性技术检测117例NAFLD 患者和120例健康对照者外周血的TNFα基因启动子区域-308、-238位点基因多态性。结果:TNFα基因- 238位点在NAFLD组中变异的G/A基因型频率比对照组明显升高(29.9%比15.8%,P<0.05),而-308位 点无显著性差异(11.0%比8.0%P>0.05)。-238位点等位基因与NAFLD有相关性。结论:TNFα基因-238 位点G/A的突变与NAFLD易感性相关。 | 黄健 李瑜元 | 2004 | 广州医学院学报2004，32，4： | 2 |
| 12 | 原发性胆汁性肝硬化免疫分子机制研究进展显示文摘原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)是一种免疫介导损伤胆管上皮细胞及肝内小胆管的胆汁淤积性自身免疫性肝病,具有发展为肝硬化的倾向。多种免疫相关基因通过影响疾病易感性、免疫调节等途径,促使PBC的发生、发展。本文就PBC的免疫分子机制研究动态进行综述。 | 尤玉琴 孔祥平 | 2012 | 传染病信息2012，25，2： | 1 |
| 13 | 广东汉族人肿瘤坏死因子α-238G/A基因多态性显示文摘目的了解广东汉族人肿瘤坏死因子(TNF)α-238G/A基因的分布特点。方法应用聚合酶链反应技术对150例正常人肿瘤坏死因子α-238G/A基因进行扩增,以Ncol进行限制性内切酶酶切图谱分析,并结合文献进行了不同种族间的分析比较。结果TNFα-238G/G、TNFα-238G/A、TNFα-238A/A表型频率分别为:0.9600、0.0400、0,TNFα-238G、TNFα-238 A基因频率分别为:0.9800、0.0200。结论肿瘤坏死因子α-238G/A基因多态性在同种族间不同地区分布无明显的的差异。 | 何炯彪 陈盛强 | 2009 | 广州医药2009，40，3： | 1 |
| 14 | 原发性胆汁性肝硬化免疫发病机制的研究进展显示文摘原发性胆汁性肝硬化(PBC)是一种自身免疫性疾病,以肝内胆管进行性破坏、慢性胆汁淤积为主要特征。PBC的发病机制复杂,涉及遗传易感性、免疫机制、感染因素及化学物质等。了解PBC的发病机制对于采取正确合理的治疗方案,降低其发病率和病死率意义重大。其中免疫机制与机体产生的自身抗体及免疫细胞分泌的多种细胞因子相关。本文就免疫因素在PBC发病机制中的作用进行综述。 | 闫伯英 胡志东 | 2009 | 医学综述2009，15，2： | 1 |
| 15 | 肿瘤坏死因子与消化系统免疫性疾病显示文摘本研究目的旨在探讨肿瘤坏死因子(TNF)与消化系统免疫性疾病的关系。TNF在消化系统疾病中具有调节免疫、炎症反应、抗肿瘤等作用,是消化系疾病发生、发展、治疗及预后过程中的重要因子。TNF在炎症性肠病的作用机制可能与皮质类固醇的抗炎症作用被血小板激活因子转录抑制有关。TNF在自身免疫性肝炎中的作用为:触发IL-6、IL-1和TNF-α本身产生的级联反应;调节HLAⅡ类分子和黏附分子的表达;抑制B细胞的激活和抗体的产生,激活巨噬细胞,促发迟发超敏反应和增加细胞毒性等。可溶性TNF在肿瘤患者中较正常人明显升高。以上理论为消化系统免疫性疾病的治疗提供理论指导,为以TNF为靶细胞的新型免疫新药对免疫相关性疾病的诊疗指引新的方向。 | 弓艳霞 唐艳萍 | 2013 | 实用临床医学(江西)2013，14，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员