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| 1 | Effect of enalapril on plasma homocysteine levels in patients with essential hypertension显示文摘Objective:To investigate the effect of enalapril on plasma homocysteine(Hcy) levels and the association of methylenetetrahydrofolate reductase(MTHFR) C677T polymorphism with the changes of Hcy levels in response to enalapril among patients with essential hypertension.Methods:A total of 130 patients with mild-to-moderate essential hypertension were enrolled and enalapril was orally administered at a dose of 10 mg/d for eight weeks.Plasma Hcy levels were measured by denaturing high-performance liquid chromatography(DHPLC) at baseline and after eight weeks of treatment.Genotyping of MTHFR C677T polymorphism was performed by TaqMan probe technique.Results:Compared with baseline,plasma Hcy levels did not change significantly after eight weeks(P=0.81).Stratified by baseline Hcy levels,a significant increase in plasma Hcy levels(P=0.02) among those with Hcy <10 μmol/L was observed,in contrast to no significant changes in plasma Hcy levels(P=0.54) among those with Hcy ≥10 μmol/L.No significant association was observed between MTHFR C677T polymorphism and changes in Hcy levels in response to enalapril.Conclusions:Enalapril may cause an increase in plasma Hcy levels among the hypertensives with low baseline Hcy levels.There was no significant association between MTHFR C677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension. | Fang-fang FAN Yong HUO Xu WANG Xin XU Bin-yan WANG Xi-ping XU Jian-ping LI | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，8： | 30 |
| 2 | The regulatory role of AT 1 receptor on activated HSCs in hepat,c fibrogenesis,effects of RAS inhibitors on hepatic fibrosis induced by CCl_4显示文摘AIM To assess the effect of ACE inhibitor andAng Ⅱ type Ⅰ(AT1)receptor antagonist inpreventing hepatic fibrosis caused by CCl4administration in rats;to investigate whether ornot there are expression of AT 1 receptors onhepatic stellate cells;and to observe the effectof Ang Ⅱ on proliferation and ECM synthesis ofcultured HSCs.METHODS Studies were conducted in maleSprague-Dawley rats.Except for thehepatofibrotic model group and the controlgroup,in three treated groups,either enalapril(5 mg/kg),or Iosartan(10 mg/kg),or enalapril+Iosartan were given to the fibrotic rats bydaily gavage,and saline vehicle was given tomodel and normal control rats.After 6 weeks,liver fibrosis was assessed directly by hepaticmorphometric analysis,which has beenconsidered the gold standard for thequantification of fibrosis.The expressions of AT1 receptors and(α-mooth muscle actin,α-SMA)in liver tissue or isolated hepatic stellate cells(HSCs)were detected by immunohistochemicaltechniques.The effect of Ang Ⅱ on HSCproliferation was determined by MTT method.Effect of Ang Ⅱ on collagen synthesis of HSCswas determined by 3H-proline incorporation.RESULTS Contrasted to the fibrosis in rats ofthe model group,groups of rats treated with either enalapril or Iosartan,or a combination oftwo drugs showed a limited expansion of theinterstitium(4.23±3.70 vs 11.22±4.79,P<0.05),but no difference was observedamong three treated groups(5.38±3.43,4.96±2.96,4.23±2.70,P>0.05).Expression of AT 1receptors was found in fibrotic interstitium offibrotic rats,whereas in normal control rats theywere limited to vasculature only to a very slightdegree.AT 1 receptors were also expressed onactivated HSCs in the culture.At concentrationsfrom 10-9to 10-5mol/L,Ang Ⅱ stimulated HSCproliferation in culture in a dose-dependentmanner.Increasing Ang Ⅱ concentrationsproduced corresponding increases in 3H-prolineincorporation.Differences among groups were significant.CONCLUSION Angiotensin-converting enzyme inhibitors and AT I blocker may slow the progression of hepatic fibrosis; activated HSCs express AT 1 receptors, and Ang Ⅱ can stimulate the proliferation and collagen synthesis of HSCs in a dose-dependent manner; and activation of RAS may be related to hepatic fibrogenesis induced by CCI4. | Hong Shan Wei Han Ming Lu Ding Guo Li Yu Tao Zhan Zhi Rong Wang Xin Huang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，6： | 27 |
| 3 | 缬沙坦与依那普利对心肌梗死后心肌胶原重构的影响显示文摘目的研究选择性血管紧张素Ⅱ受体1拮抗剂(AR1B)、血管紧张素转化酶抑制剂(ACEI)对心肌梗死(MI)后心肌胶原重构的影响。方法新西兰大白兔心梗后随机分组用Valsartan治疗(V组)、Enalapril治疗(E组)或不治疗(C组),并设假手术组(S组)。治疗10周后测量血流动力学参数、胶原含量。结果MI后10周C组梗死区和非梗死区胶原含量明显高于S组。V,E组中上述指标显著下降,但仍高于S组。非梗死区胶原含量与左室舒张末压呈明显正相关。结论①在家兔心梗后早期应用Valsartan,Enalapril能改善血流动力学、抑制心肌纤维化;②非梗死区胶原沉积是降低心功能的主要因素之一。非梗死区胶原含量与左室舒张末压有明显相关性。 | 吕立文 韦金儒 李醒三 | 2005 | 广东医学2005，26，5： | 6 |
| 4 | 关于国外依那普利研究的文献分析显示文摘本文以MEDLINE光盘数据库(1987.1~1997.9)作为文献源,对有关依那普利(Enalapril)研究的文献进行数据处理。通过十一年来该药物3345篇相关文献的数量、语种、国家、期刊、副主题词及主要主题词进行分析,统计各项分布特点,讨论了依那普利的研究现状。 | 高承梅 郭强 | 1998 | 医学信息学杂志1998，25，6： | 2 |
| 5 | 环孢菌素A致大鼠肾小管间质细胞凋亡及Losartan、Enalapril的保护作用显示文摘以低盐饮食 (钠含量 0 .0 5 % )饲养大鼠 7天后随机分成①对照组 ,②CsA处理组 ,③CsA +盐酸维拉帕米处理组 ,④CsA +Losartan处理组 ,⑤CsA +Enalapril处理组。CsA皮下注射剂量为 15mg/ (kg·d) ,连续 4周。用TUNEL法检测凋亡细胞 ,免疫组化方法观察增殖细胞核抗原 (PCNA)、Fas抗原表达。结果发现CsA处理后大鼠肾小管间质凋亡细胞较对照组明显增加 ,增殖细胞也有代偿性增加 ,肾小管上皮细胞Fas抗原表达增多。与CsA处理组相比 ,Losartan、Enalapril处理组肾小管间质细胞凋亡和Fas抗原表达明显减少。结果提示CsA可促进肾小管间质细胞凋亡 ,导致肾小管间质纤维化 ,Fas可能是介导肾小管细胞凋亡的重要介质。Losartan、Enalapril对CsA所致的肾小管间质细胞凋亡有保护作用。 | 张国华 张训 侯凡凡 王力 易朝辉 | 2001 | 解放军医学杂志2001，26，3： | 2 |
| 6 | enalapril对不同肾功能高血压患者血管活性物质的作用显示文摘为转换酶抑制剂(ACEI)治疗高血压提供理论依据。方法25例高血压患者按内生肌酐清除率分为肾功能正常10例,代偿8例和氮质血症7例3组。观察ACEIenalapril(10~30mg/d)4周对血管活性物质,包括血浆肾素活性(PRA),血管紧张素Ⅱ(ATⅡ),转换酶(ACE),心钠素(ANF),尿醛固酮(Aldo),缓激肽(BK)和前列腺素E2(PGE2)的作用。结果1.服药前3组患者与正常人比,ATⅡ升高,PRA,Aldo无差异;氮质血症组患者BK降低,ANF增高;2.服药后3组患者ATⅡ,Aldo和ANF下降,BK(除氮质血症组),PGE2和PRA升高;3.治疗后ATⅡ与Aldo、ATⅡ与ANF以及BK与PGE2分别呈正相关。结论1.肾素-血管紧张素系统(RAS)与BK-PGS两系统相互调节在不同肾功能高血压患者的发病中起着作用,并有着治疗意义;2. | 陈绍行 郭冀珍 宋代军 陈贤妙 曹素玲 钱文琪 胡亚蓉 龚兰生 | 1996 | 中华肾脏病杂志1996，12，4： | 1 |
| 7 | 新型血管紧张素转化酶抑制剂Enalapril的合成研究显示文摘本文报道了以苯和顺丁烯二酸酐为起始原料合成新型血管紧张素转化酶抑制剂Enalapril的新合成方法,总收率为16.2%;此路线无特殊设备及试剂要求,具有SS-构型的(4)非对映异构体在无水乙醇中溶解度小,沉淀析出,而使(4)的SS-构型和RS-构型的两个非对映异构体分开。 | 李万玉 余瑜 靳红卫 | 1995 | 中国药物化学杂志1995，5，3： | 1 |
| 8 | Enalapril Combined with Hydrochlorothiazide and Indapamide in the Treatment of Hypertension with Heart Failure显示文摘Objecrive:To explore the effect of enalapril combined with hydroch1orothiazide and indapamide on hypertension and heart failure.Methods:8o patients with hypertension and heart failure admitted to our hospitail from January 2019 to January 2020 were selected as the research subjects,and they were divided into two groups with random number table method,40 cases each.The control group was given conventional treatment regimens,including enalapril and hydroch1orothiazide;the observation group replaced hydrochlorothiazide with indapamide based on the above therapies.The efficacy and systolic blood pressure,diastolic blood pressure and left heart ejection fraction(LVEF)of the two groups were compared.Results:After treatment,the effective rate of the observation group was 92.50%(37/40)higher than that of the control group 75.00%(30/40).The systolic and diastolic blood pressure were lower than those of the control group,and the LVEF was higher than that of the control group.The difference was statistically significant(P<0.05).Conclusion:Enalapril combined with indapamide is effective in the treatment of hypertension with heart failure,which can help 1ower blood pressure,reduce heart 1oad,increase cardiac output,reverse ventricular remodeling,and delay disease progression. | Xueting Sun | 2020 | Journal of Clinical and Nursing Research2020，4，4： | 1 |
| 9 | Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis显示文摘AIM: To investigate the protective effect of paricalcitol and enalapril on renal inflammation and oxidative stress in Apo E-knock out mice. METHODS: Animals treated for 4 mo as group(1) Apo E-knock out plus vehicle, group(2) Apo E-knock out plus paricalcitol(200 ng thrice a week),(3) Apo Eknock out plus enalapril(30 mg/L),(4) Apo E-knock out plus paricalcitol plus enalapril and(5) normal. Blood pressure(BP) was recorded using tail cuff method. The kidneys were isolated for biochemical assays using spectrophotometer and Western blot analyses. RESULTS: Apo E-deficient mice developed high BP(127 ± 3 mm Hg) and it was ameliorated by enalapril and enalapril plus paricalcitol treatments but not with paricalcitol alone. Renal malondialdehyde concentrations, p22 phox, manganese-superoxide dismutase, inducible nitric oxide synthase(NOS), monocyte chemoattractant protein-1, tumor necrosis factor-alpha and transforming growth factor-β1 levels significantly elevated but reduced glutathione, Cu Zn-SOD and e NOS levels significantly depleted in Apo E-knock out animals compared to normal. Administration of paricalcitol, enalapril and combined together ameliorated the renal inflammation and oxidative stress in Apo E-knock out animals. CONCLUSION: Paricalcitol and enalapril combo treatment ameliorates renal inflammation as well as oxidative stress in atherosclerotic animals. | Kazim Husain Edu Suarez Angel Isidro Wilfredo Hernandez Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 1 |
| 10 | Enalapril长期使用可减缓糖尿病病情恶化显示文摘最新研究证实,对无显著高血压的微蛋白尿症糖尿病患者而言,长期的Enalapril治疗可减缓或延迟结构性肾小球损伤的恶化。Enalapril是一种血管紧张素转化酶(ACE)抑制剂。 | 刘畅 | 2004 | 国外医学情报2004，25，3： | 0 |
| 11 | Enalapril对人精子活力的影响显示文摘一些研究已经表明,在男性生殖系统包括睾丸、附睾、输精管和前列腺中存在有血管紧张素转化酶(ACE)。最近又已证明在精子和精液中也存在有ACE。然而目前对ACE在男性生殖机能中所起的确切作用尚不清楚。 | Ratnasooriya WD 王玉梅 | 1991 | 国外医学(计划生育分册)1991，10，1： | 0 |
| 12 | 依那普利(enalapril)和地高辛治疗充血性心力衰竭之比较显示文摘作者以原先使用地高辛治疗的充血性心力衰竭(CHF)患者为对象,比较依那普利和地高辛的疗效和耐受性。 | 李仁嘉 | 1989 | 国际心血管病杂志1989，32，5： | 0 |
| 13 | Therapeutic Effect of Nifedipine Combined with Enalapril on Elderly Patients with Coronary Heart Disease Complicated with Hypertension显示文摘The objective of this study was to analyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.66 elderly patients with coronary heart disease and hypertension were enrolled from December 2016 to November 2017.They were randomly divided into two groups,33 patients in each group.Patients in the experimental group received nifedipine.In combination with enalapril,patients enrolled in the control group received nifedipine monotherapy.Compared with the control group,the total effective rate,serum nitric oxide(NO)after treatment,C-reactive protein(CRP)after treatment,homocysteine(HCY)after treatment,and blood pressure after treatment were significantly improved(P<0.05).There were no significant differences in serum NO,pre-treatment CRP,pre-treatment HCY,pre-treatment blood pressure,and adverse reactions during treatment between the two groups(P>0.05).The elderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril. | Xiaoye Wang | 2018 | Journal of Clinical and Nursing Research2018，2，6： | 0 |
| 14 | Enalapril改善妊高征左室收缩功能的研究显示文摘本文应用彩色多普勒血流显像(CDFI)技术检测妊高征心功能不全患者Enalapril治疗前后左室收缩功能参数的变化,经统计学处理表明妊高征引起的心功能不全,单纯用EnalaPril治疗效果不及强心类药物,联合用药能更好地改善左室收缩功能,即Enalapril是治疗妊高征左心功能不全者的良好辅助用药。 | 董磊 李红 李新民 管一帆 杨颖莉 李公义 蔡国良 | 1998 | 上海医学影像1998，7，2： | 0 |
| 15 | 经典回顾:心脏结局预防评估研究将冠状动脉性心脏病药物治疗带入新时期显示文摘基础研究显示,肾素血管紧张素系统(renin-an-giotensinsystem,RAS)在心血管疾病的发生发展中发挥着重要作用,因此,很多学者认为通过药物治疗阻断RAS有助于改善心血管病患者预后。1987年发表的北斯堪地那维亚依那普利生存协作研究(coopera-tive North Scandinavian enalapril survival study, | 郭艺芳 | 2014 | 中华高血压杂志2014，22，7： | 0 |
| 16 | Enalapril对扩张型心肌病心衰的急性循环效应显示文摘本文报告5例扩张型心肌病顽固性心衰者口服Enalapril 5mg、10mg 后,应用正规的创伤性血流动力学检查方法,分别测定服药前、后,不同时间内右房压(RAP)、肺毛细血管楔嵌压(PCWP)、心率(HR)、血中血管紧张素转换酶(ACE)活性和醛固酮含量(AsC)。结果表明,服Enalapril 后2~6h RAP、PCWP、ACE 活性和AsC 均下降,且呈剂量依赖性。HR 不变。证明本药对扩张型心肌病顽固心衰的急性循环效应良好。系长期抗心衰治疗的重要辅助药物。 | 吕卓梅 吴晔良 陈洞 马文珠 王敬良 | 1991 | 江苏医药1991，17，3： | 0 |
| 17 | Enalapril对实验性糖尿病大鼠肾脏的保护作用机理研究显示文摘目的 研究血管紧张素转换酶抑制剂 Enalapril对糖尿病的肾病治疗作用机理。方法 以Enalapril治疗实验性糖尿病大鼠 ,并将正常组、糖尿病对照组及治疗组尿蛋白水平及肾组织转化生长因子 β、糖基化终末产物含量进行比较。结果 Enalapril治疗组大鼠肾组织转化生长因子 β及糖基化终末产物含量与糖尿病对照组相比无下降。结论 Enalapril的肾脏保护作用并非通过抑制肾组织转化生长因子 | 傅静奕 田浩明 梁荩忠 | 2001 | 华西医科大学学报2001，32，1： | 0 |
| 18 | 扩管药在难治性心力衰竭中的应用显示文摘难治性心力衰竭(RHF)是指经积极常规治疗后仍无效的心力衰竭。其病因多见于严重器质性心脏病,如心脏严重机械性阻碍,心肌大面积严重的器质性损害等各种心脏病引起的RHF。其特点是由于心排血量减少,反射性引起体循环血管阻力增加,以维持一定灌注压。因此,应用血管扩张药,降低心脏前后负荷,减轻肺淤血,增加心输出量,从而改善症状及心功能。 (一)扩张小静脉为主的药物 1.硝酸甘油:主要扩张容量血管,静脉点滴用5~10mg硝酸甘油加5%葡萄糖液以20~80μg/分速度持续滴注6~8小时,半寿期19分钟,适于急性心力衰竭伴左室舒张末期压(LVEDP)增加。 | 陈荣贵 | 1988 | 医药导报1988，7，1： | 0 |
| 19 | Effect of Enalapril Maleate and folic acid tablets combined with Tongxinluo on the proliferation of aortic smooth muscle cells in rats induced by methionine显示文摘Objective To explore the effect of enalaprilat maleate and folic acid tablets combined with Tongxinluo on methione-induced proliferation of aortic smooth muscle cells in rats.Methods The proliferation of rat aortic smooth muscle cells was induced by the methionine and the cells were incubated with enalapril mateate and folate tablets and Tongxinluo alone or in combination. The cells were assigned to control group. | 黄剑峰 | 2022 | China Medical Abstracts(Internal Medicine)2022，39，2： | 0 |
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