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| 1 | Effects of early enteral nutrition on immune function of severe acute pancreatitis patients显示文摘AIM:To investigate the effects of early enteral nutrition (EEN) on the immune function and clinical outcome of patients with severe acute pancreatitis (SAP).METHODS:Patients were randomly allocated to receive EEN or delayed enteral nutrition (DEN).Enteral nutrition was started within 48 h after admission in EEN group,whereas from the 8 th day in DEN group.All the immunologic parameters and C-reactive protein (CRP) levels were collected on days 1,3,7 and 14 after admission.The clinical outcome variables were also recorded.RESULTS:Sixty SAP patients were enrolled to this study.The CD4+ T-lymphocyte percentage,CD4+/CD8+ ratio,and the CRP levels in EEN group became significantly lower than in DEN group from the 7 th day after admission.In contrast,the immunoglobulin G(IgG) levels and human leukocyte antigen-DR expression in EEN group became significantly higher than in DEN group from the 7 th day after admission.No difference of CD8+ T-lymphocyte percentage,IgM and IgA levels was found between the two groups.The incidences of multiple organ dysfunction syndrome,systemic inflammatory response syndrome,and pancreatic infection as well as the duration of intensive care unit stay were significantly lower in EEN group than in DEN group.However,there was no difference of hospital mortality between the two groups.CONCLUSION:EEN moderates the excessive immune response during the early stage of SAP without leading to subsequent immunosuppression.EEN can improve the clinical outcome,but not decrease the hospital mortality of SAP patients. | Jia-Kui Sun Xin-Wei Mu Wei-Qin Li Zhi-Hui Tong Jing Li Shu-Yun Zheng | 2013 | World Journal of Gastroenterology2013，19，6： | 106 |
| 2 | 大陆造山运动:从大洋俯冲到大陆俯冲、碰撞、折返的时限--以北祁连山、柴北缘为例显示文摘北祁连山和柴北缘是典型的早古生代大陆造山带,分别发育有北祁连山大洋型俯冲缝合带和柴北缘大陆型俯冲碰撞带。作为早古生代大洋冷俯冲的典型代表,北祁连山经历了从新元古代-寒武纪大洋扩张、奥陶纪俯冲和闭合及早泥盆世隆升造山的过程。高压变质岩变质年龄为490~440Ma,证明古祁连洋经历了至少50m.y.的俯冲过程。柴北缘超高压变质带是大陆深俯冲的结果,岩石学、地球化学和同位素年代学表明,柴北缘超高压变质带中榴辉岩的原岩分别来自洋壳和陆壳两种环境。高压/超高压变质的蛇绿岩原岩的年龄为517±11Ma,与祁连山蛇绿岩年龄一致。榴辉岩早期的变质年龄为443~473Ma,与祁连山高压变质年龄一致,代表大洋地壳俯冲的时代,而柯石英片麻岩和石榴橄榄岩所限定的超高压变质时代为420~426Ma,代表大陆俯冲的年龄。从大洋俯冲结束到大陆俯冲最大深度的转换时间最少需要20m.y.。自420Ma起,俯冲的大洋岩石圈与跟随俯冲的大陆岩石圈断离,大陆地壳开始折返,发生隆升和造山。北祁连山和柴北缘两个不同类型的高压-超高压变质带反映了早古生代从大洋俯冲到大陆俯冲、隆升折返的造山过程。 | 宋述光 牛耀龄 张立飞 张贵宾 | 2009 | 岩石学报2009，25，9： | 99 |
| 3 | Esophageal cancer: Risk factors,screening and endoscopic treatment in Western and Eastern countries显示文摘Esophageal cancer is one of the most unknown and deadliest cancers worldwide,mainly because of its extremely aggressive nature and poor survival rate.Esophageal cancer is the 6th leading cause of death from cancer and the 8th most common cancer in the world.The 5-year survival is around 15%-25%.There are clear differences between the risk factors of both histological types that affect their incidence and distribution worldwide.There are areas of high incidence of squamous cell carcinoma(some areas in China) that meet the requirements for cost-effectiveness of endoscopy for early diagnosis in the general population of those areas.In Europe and United States the predominant histologic subtype is adenocarcinoma.The role of early diagnosis of adenocarcinoma in Barrett's esophagus remains controversial.The differences in the therapeutic management of early esophageal carcinoma(high-grade dysplasia,T1 a,T1 b,N0) between different parts of the world may be explained by the number of cancers diagnosed at an early stage.In areas where the incidence is high(China and Japan among others) early diagnoses is more frequent and has led to the development of endoscopic techniques for definitive treatment that achieve very effective results with a minimum number of complications and preserving the functionality of the esophagus. | María José Domper Arnal ángel Ferrández Arenas ángel Lanas Arbeloa | 2015 | World Journal of Gastroenterology2015，21，26： | 116 |
| 4 | Early Yanshanian post-orogenic granitoids in the Nanling region——Petrological constraints and geodynamic settings显示文摘Early Yanshanian magmatic suites predominate absolutely in the Nanling granite belt. They consist mainly of monzogranite and K-feldspar granite. There occur associations of early Yanshanian A-type granitoids (176 Ma-178 Ma) and bimodal volcanic rocks (158 Ma-179 Ma) in southern Jiangxi and southwestern Fujian in the eastern sector of the granite belt and early Yanshanian basalts (177 Ma-178 Ma) in southern Hunan in the central sector of the belt. Both the acid end-member rhyolite in the bimodal volcanic rock association and A-type granitoids in southern Jiangxi have the geochemical characteristics of intraplate granitic rocks and the basic end-member basalt of the association is intraplate tholeiite, while the basaltic rocks in southern Hunan include not only intraplate tholeiite but also intraplate alkali basalt. Therefore the early Yanshanian magmatic suites in the Nanling region are undoubtedly typical post-orogenic rock associations. Post-orogenic suites mark the end of a post-collision or late | 陈培荣 陆建军 范春方 华仁民 章邦桐 | 2002 | Science China Earth Sciences2002，45，8： | 61 |
| 5 | 内蒙古中部四子王旗大庙岩体时代及成因显示文摘华北北缘的内蒙古中部地区出露大量晚古生代-早中生代花岗岩类,在空间上构成一条巨大的东西向花岗岩带。四子王旗大庙岩体作为一个典型的代表,以花岗闪长岩为主,其内部普遍发育暗色微粒包体(MMEs),是认识花岗岩岩石成因和演化的关键。本文对包体及寄主岩进行了同位素测年、岩相学、矿物化学、全岩主量元素和微量元素分析。寄主岩石中的锆石LA-ICPMS U-Pb年龄平均为265±7Ma(2σ),包体中单颗粒黑云母Rb-Sr年龄为253±5Ma(MSWD=0.85),属晚二叠世-早三叠世岩浆活动的产物。包体具塑性外形及岩浆结构,存在多种不平衡矿物组合;MME中的斜长石An组分及黑云母斑晶中MgO成分呈多期震荡,同时总体上均显示出幔部高于核、边部的特征,暗示斑晶可能为围岩捕虏晶,这种相似的成分变化指示包体与寄主岩相互作用引起的结晶环境改变,标志着岩浆成分的变化,是岩浆混合的标志之一;主量和微量数据进一步证明岩体的岩浆混合成因。Rb/Sr-K/Rb变化关系反映包体非结晶分异或黑云母堆晶的产物,而Ce/Pb-Ce、Ba-δEU和P_2O_5-δEu图及其他微量元素比值图等均表明花岗闪长岩体发生了岩浆混合作用,这也得到岩浆物理化学条件的支持。岩浆底侵和岩浆混合作用是该区岩体形成的主要机制和方式。岩石地球化学特征表明该岩体不同于加厚地壳和俯冲洋壳熔融的TTG和埃达克质岩石,而黑云母矿物化学和岩石地球化学显示其构造背景很可能为同碰撞环境。 | 章永梅 张华锋 刘文灿 周志广 | 2009 | 岩石学报2009，25，12： | 63 |
| 6 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 7 | Specific molecular markers in hepatocellular carcinoma显示文摘BACKGROUND: The carcinogenesis of hepatocellular carcinoma (HCC) is a multi-factorial, multistep and complex process. Its prognosis is poor, and early diagnosis and monitoring metastasis of HCC is of the utmost importance. Circulating diagnostic and prognostic biomarkers could be used in proper postoperative treatment of patients at an early stage of HCC development. This review summarizes recent studies of the specific biomarkers in diagnosis and monitoring metastasis or postoperative recurrence of HCC. DATA SOURCES: An English-language literature search was conducted using MEDLINE (June 1998 to September 2006) on researches of some valuable specific biomarkers in diagnosis and monitoring metastasis or postoperative recurrence of HCC. RESULTS: Hepatoma tissues can synthesize various tumor-related proteins, polypeptides, and isoenzymes, such as alpha-fetoprotein (AFP), hepatoma-specific gamma-glutamyl transpeptidase (HS-GGT), etc, and then secrete into blood. The valuable early diagnostic and prognostic biomarkers could predict the development and metastases of HCC. Recent researches have confirmed that circulating hepatoma-specific AFP subfraction, transforming growth factor (TGF)-β1, HS-GGT, and free insulin-like growth factor (IGF)-Ⅱ may be more specific markers than total AFP level for early diagnosis for HCC. The circulating genetic markers such as AFP-mRNA, TGF-β1-mRNA, IGF-Ⅱ-mRNA, etc from peripheral blood mononuclear cells of HCC patients have been most extensively used in monitoring distal metastasis or postoperative recurrence of HCC. CONCLUSIONS: Hepatoma tissues synthesize and secrete valuable molecular markers into blood. The analyses of circulating hepatoma-specific biomarkers are usefulto early diagnosis of HCC or monitoring metastasis or postoperative recurrence of HCC. | Yao, Deng-Fu Dong, Zhi-Zhen Yao, Min | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 55 |
| 8 | Missed diagnosis of early gastric cancer or high-grade intraepithelial neoplasia显示文摘AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected by esophagogastroduodenos-copy (EGD) and pathological analysis from January 2010 to December 2011. Dimethyl silicone oil was administrated orally 15 min before the EGD procedures. The stomach was cleaned by repeated washing with saline when the gastroscope entered the stomach cavity. Suspected EGC lesions were subject to conventional biopsy sampling and pathological examinations. The correlation between lesion locations, endoscopic morphology of cancerous sites, training level of the examiners, pathological biopsies, and missed diagnosis was analyzed. RESULTS: Twenty-three cases were missed among the 103 cases (22.23%) of EGC/HGIN. The rate of missed EGC in the gastroesophageal junction (8/19, 42.1%) was significantly higher than at other sites (15/84, 17.86%) (χ2 = 5.253, P = 0.022). In contrast, the rate of missed EGC in the lower stomach body (2/14, 14.29%) was lower than at other sites (21/89,23.6%), but there were no significant differences (χ2 = 0.289, P = 0.591). The rate of missed EGC in the gastric antrum (5/33, 15.15%) was lower than at other sites (18/70, 25.71%), but there were no significant differences (χ2 = 1.443, P = 0.230). Endoscopists from less prestigious hospitals were more prone to not diagnosing EGC than those from more prestigious hospitals (χ2 = 4.261, P = 0.039). When the number of biopsies was < 4, the rate of missed diagnosis was higher (20/23, 89.96%) than for when there were > 4 biopsies (3/23, 13.04%) (P < 0.001). In addition, there was no significant difference in the rate of missed diagnosis in patients with 1-3 biopsy specimens (χ2 = 0.141, P = 0.932). CONCLUSION: Endoscopists should have a clear understanding of the anatomical characteristics of the esophagus/stomach, and endoscopic identification of early lesions increases with the number of biopsies. | Wei Ren Jin Yu Zhi-Mei Zhang Yuan-Kun Song Yi-Hui Li Lei Wang | 2013 | World Journal of Gastroenterology2013，19，13： | 58 |
| 9 | 黑龙江杂岩的碎屑锆石年代及其大地构造意义显示文摘黑龙江杂岩带位于佳木斯地体西缘,为佳木斯地体向西与松嫩地体之间俯冲、拼贴、碰撞而形成的高压变质带。黑龙江杂岩沿牡丹江断裂分布,其构造-岩石组合、变质变形特征等显示其为佳木斯地体向松嫩地体俯冲拼帖的过程中形成的增生杂岩,目前保存下来的杂岩带应为大规模增生楔仰冲到佳木斯地体之上的残余部分。88颗碎屑锆石的全部样品SHRIMPU-Pb年代学测试结果显示三个主要年龄区间:170~220Ma,峰值年龄为183Ma;240~338Ma,峰值年龄为256Ma;450~520Ma,峰值年龄为470Ma。而28个碎屑锆石谐和年龄的年龄谱为两组:240~338Ma,峰值年龄为256Ma;450~500Ma,峰值年龄为470Ma。碎屑锆石年龄数据分析得到,240~338Ma峰期年龄为256Ma的年龄应代表黑龙江杂岩主体岩石的沉积年龄上限;而450~500Ma的年龄谱对应于佳木斯地体的基底变质岩年龄,显示佳木斯地体的基底变质岩曾为黑龙江杂岩的物源区;而170~210Ma,峰期年龄为183Ma的不谐和年龄应为受印支期-早侏罗世构造热事件的扰动年龄,与该区变质单矿物的Ar-Ar年龄相一致,应代表了该区陆-陆碰撞的时代。上述年龄为黑龙江杂岩的形成与演化提供了重要的地质年代学制约,即黑龙江杂岩的原岩成岩时代上限为早三叠世,佳木斯地体向西的俯冲时代主体为印支期,而陆-陆拼贴及碰撞过程主要为晚印支期并可能持续到早侏罗世。这些结果将为揭示我国东北地区构造演化的年代学格架以及三叠纪古亚洲构造域向环太平洋构造域叠加和转换的动力学背景研究提供新的基本地质事实依据。 | 周建波 张兴洲 Simon A WILDE 郑常青 金魏 陈红 韩杰 | 2009 | 岩石学报2009，25，8： | 55 |
| 10 | Endoscopic submucosal dissection vs endoscopic mucosal resection for early gastric cancer: A meta-analysis显示文摘AIM: To compare endoscopic submucosal dissection(ESD) and endoscopic mucosal resection(EMR) for early gastric cancer(EGC).METHODS: Computerized bibliographic search was performed on PubMed/Medline, Embase, Google Schol-ar and Cochrane library databases. Quality of each included study was assessed according to current Co-chrane guidelines. Primary endpoints were en bloc re-section rate and histologically complete resection rate. Secondary endpoints were length of procedure, post-treatment bleeding, post-procedural perforation and re-currence rate. Comparisons between the two treatment groups across all the included studies were performed by using Mantel-Haenszel test for fixed-effects mod-els(in case of low heterogeneity) or DerSimonian and Laird test for random-effects models(in case of high heterogeneity).RESULTS: Ten retrospective studies(8 full text and 2 abstracts) were included in the meta-analysis. Overall data on 4328 lesions, 1916 in the ESD and 2412 in the EMR group were pooled and analyzed. The mean operation time was longer for ESD than for EMR(stan-dardized mean difference 1.73, 95%CI: 0.52-2.95, P =0.005) and the 'en bloc ' and histological complete re-section rates were significantly higher in the ESD group [OR = 9.69(95%CI: 7.74-12.13), P < 0.001 and OR = 5.66,(95%CI: 2.92-10.96), P < 0.001, respectively]. As a consequence of its greater radicality, ESD provided lower recurrence rate [OR = 0.09,(95%CI: 0.05-0.17), P < 0.001]. Among complications, perforation rate was significantly higher after ESD [OR = 4.67,(95%CI, 2.77-7.87), P < 0.001] whereas the bleeding incidences did not differ between the two techniques [OR = 1.49(0.6-3.71), P = 0.39].CONCLUSION: In the endoscopic therapy of EGC, ESD showed a superior efficacy but higher complication rate with respect to EMR. | Antonio Facciorusso Matteo Antonino Marianna Di Maso Nicola Muscatiello | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，11： | 50 |
| 11 | 大兴安岭地区德尔布干断裂带北段构造年代学研究显示文摘德尔布干断裂带是大兴安岭隆起西侧NE向的重要断裂带,处在海拉尔-拉布达林-根河盆地西缘,是著名德尔布干成矿区东南边界断裂带。为了确定德尔布干断裂带运动性质、活动时间,深入探讨该断裂带与中生代海拉尔-拉布达林-根河盆地及大兴安岭盆山格局、认识德尔布干断裂带多金属矿床成因等问题,本文应用锆石SHRIMP和云母^(40)At/^(39)Ar定年技术,分别对断裂带内的细粒黑云母花岗岩侵入体、韧性变形的花岗闪长质片麻岩、白云母石英片岩,进行了同位素年代学研究。其中花岗闪长质片麻岩岩浆型锆石SHRIMP谐和年龄300.6±9.3Ma,为花岗闪长质片麻岩海西期的侵位年龄;而花岗闪长质片麻岩中黑云母^(40)At/^(39)Ar坪年龄是130.9±1.4Ma,白云母石英片岩的白云母^(40)Ar/^(39)Ar坪年龄是115.6±1.6Ma,代表早白垩世伸展构造变形年龄;细粒黑云母花岗岩侵入体岩浆型锆石SHRIMP谐和年龄130.1±1.4Ma,为同伸展构造变形侵位的岩浆事件。上述地质年代说明德尔布干断裂带是早白垩世(110~130Ma)该区最年轻的重大伸展构造变形产物。控制NE向大兴安岭隆起和中生代海拉尔-拉布达林-根河等火山沉积盆地的发育格局、以及中生代以来的地壳演化与成矿类型。 | 郑常青 周建波 金巍 季建清 张兴洲 马志红 丁雪 | 2009 | 岩石学报2009，25，8： | 42 |
| 12 | Early Paleozoic subduction of the Paleo-Asian Ocean: Geochronological and geochemical evidence from the Dashizhai basalts, Inner Mongolia显示文摘Zircon U-Pb results of basalt from the Dashizhai Town in Inner Mongolia, NE China, shows that the basaltic lava was erupted at 439±3 Ma, much older than the 'Permian basalts' as previously thought. These rocks show arc-type trace element patterns (i.e., Nb-Ta depletion and light REE and large ion lithophile element enrichment) and unradiogenic Sr and highly radiogenic Nd and Hf isotope compositions. They can be subdivided into two petrogenetic groups: Group 1 basalts have relatively high TiO2, MgO and compatible elements and low Sr and Th, characterized by mid-oceanic ridge basalt (MORB)-type Sr-Nd-Hf isotope compositions (87Sr/86Sr(i)=0.7028―0.7032, εNd(t)=+9.8-+11.2, εHf(t)=+16.1- +18.4). Group 2 has lower TiO2, MgO and compatible elements and higher Sr and Th, and relatively evolved Sr-Nd-Hf isotope compositions (87Sr/86Sr(i)=0.7037-0.7038, εNd(t)=+5.7-+7.3, εHf(t)=+12.6- +13.0). Both groups were interpreted as melts derived from a metasomatized mantle wedge formed during the subduction of Paleo-Asian Ocean. The mantle source for Group 1 was probably a highly isotopically depleted oceanic mantle modified by predominant slab fluids; whereas subducted sediments had an important contribution to the melting source for Group 2. The petrogenesis of the Dashizhai basalts provides clear evidence for early Paleozoic subduction of the Paleo-Asian Ocean, and the highly radiogenic Nd and Hf compositions in these rocks suggest that these lavas and their possible intrusive counterparts were one of the important components for Phanerozoic crustal growth. Our and previous studies on the 'Dashizhai Formation' volcanic rocks yield an unrealistic eruption range of 440-270 Ma for different rock types, we thus advise to disassemble the previously defined 'Dashizhai Formation' into multiple lithologic units and to reinterpret the spatial and temporal distributions of different volcano-sedimentary associations. | GUO Feng FAN WeiMing LI ChaoWen MIAO LaiCheng ZHAO Liang | 2009 | Science China Earth Sciences2009，52，7： | 37 |
| 13 | Discovery of eclogite inclusions and its geological significance in early Jurassic intrusive complex in Xuzhou-northern Anhui, eastern China显示文摘The early Jurassic intrusive complex is chiefly made of monzodioritic porphyry in northern Anhui and northern Jiangsu, which emplaced in 191 Ma. The intrusive complexes contain a lot of eclogite inclusions which belong to eclogite and garnet-pyroxenite. The inclusions had undergone eclogite facies high-pressure metamorphism and am-phibolite facies retrogressive metamorphism. The garnets in eclogite inclusions are mainly almandine varieties and clino-pyroxenes are omphacite and augite. The mineral assemblage and P-T estimation results show that P-T conditions of eclogite facies metamorphism and amphibolite facies retrogressive metamorphism are over 1.2-1.5 GPa, 709-861°C and 0.7-1.03 GPa, 666-738°C, respectively. The discovery of the high-pressure xenoliths not only is of important significance to understand the composition and structure of deep crust in southern edge of North China Platform, but also can be of important influence on realizing the subduc-tion-collision-exhumation evolutional process | Wenliang Xu Dongyan Wang Xiaochun Liu Qinghai Wang Jingqian Lin | 2002 | Chinese Science Bulletin2002，47，14： | 37 |
| 14 | 西昆仑-塔西南坳陷晚古生代以来的沉积构造演化显示文摘自柯克亚深层油气勘探取得突破以来,塔西南坳陷一直受到各类地质学家的广泛关注,有关该盆地的形成和演化历史及其油气资源评价近年来更是成为人们的研究热点。本文在总结前人资料的基础上,探讨塔西南和西昆仑地区自晚古生代以来所经历的构造及沉积格架的演变过程,对塔西南坳陷性质及其演化阶段划分所存在的争议进行了归纳,分析了塔西南-西昆仑这一盆山体系形成和演化中的构造变形和沉积记录。总体来说,根据现有沉积和构造变形资料,中生代之前西昆仑和塔西南坳陷分别处于同一构造背景下的不同沉积单元;二者之间盆山体系的形成主要自晚侏罗世-早白垩世,中-上新世是造盆造山作用机制发生重大转折的时期,或者说早更新世末的构造运动基本上奠定了西昆仑-塔里木盆地南缘现今的盆-山构造格架。 | 方爱民 马建英 王世刚 赵越 胡健民 | 2009 | 岩石学报2009，25，12： | 40 |
| 15 | 艾滋病感染者和病人随访干预效果分析显示文摘目的 了解艾滋病感染者和病人艾滋病知识知晓情况及与配偶/固定性伴性行为情况等,初步分析随访干预效果.方法 对艾滋病感染者和病人进行基线调查,收集艾滋病相关知识、性行为等信息,并进行健康教育、安全套推广、转介治疗等随访干预,6个月后进行1次随访调查.结果 调查对象的艾滋病知识和相关服务知晓率在基线调查时约为70.0%~ 80.0%,随访时达100.0%;基线中最近6个月与配偶/固定性伴发生性行为时50.0%未每次使用安全套;3.2%有商业性行为,1.5%有临时性行为.随访调查时与配偶/固定性伴发生性行为,仅1人从未使用安全套,而且最近6个月均没有发生过商业性行为和临时性行为.结论 加强对艾滋病感染者和病人随访管理,强化干预措施,对提高他们的艾滋病防治知识知晓率、减低危险行为从而减少传播风险起到积极的促进作用. | 朱秋映 朱金辉 刘伟 郑文彬 | 2014 | 中华疾病控制杂志2014，18，1： | 36 |
| 16 | 改良早期预警评分在评估院前急性中毒患者病情及预后的应用研究显示文摘目的 研究改良早期预警评分(modified early warning scores,MEWS)在院前急性中毒患者病情评估和死亡预测的价值及可行性.方法 以2010年1月1日至2010年12月31日院前急性中毒患者作为研究对象,进行前瞻性观察性研究,现场采集相关数据,进行MEWS评分,以收入院后90 d为观察终点,结局作为观察指标.计数资料以百分比表示,用x2检验,计量资料以均数±标准差((x)±s)表示,用成组t检验,以P <0.05为差异具有统计学意义,对患者进行MEWS评分工作特征曲线(receiver operating characteristic curve,ROC)下面积计算,计算患者相应的预测指标.结果 0~6分的患者287例次,占94.4%;7~13分共17例次,占5.59%;死亡组MEWS评分较存活组高,差异有统计学意义(P<0.05);MEWS评分ROC曲线下面积为0.99,判断院前中毒患者“潜在危重症”的最佳截断点为≥7分,对危重症患者死亡预测的敏感度91.7%,特异度为97.9%,准确度为97.7%,约登指数为0.896.表明MEWS评分在急性中毒患者病情评估及死亡的预测具有较强的应用价值.结论 MEWS评分对院前急性中毒患者病情评估及死亡的预测具有较高的分辨能力,此评分方法简单、实用、可操作性强,有较强的应用价值. | 黄翔 阮海林 黄伟 方量 | 2014 | 中华急诊医学杂志2014，23，4： | 36 |
| 17 | The subduction of the west Pacific plate and the destruction of the North China Craton显示文摘While a general concensus has recently been reached as to the causal relationship between the subduction of the west Pacific plate and the destruction of the North China Craton, a number of important questions remain to answer, including the initial subduction of west Pacific plate beneath the eastern Asian continent, the position of west Pacific subduction zone during the peak period of decratonization(i.e., Early Cretaceous), the formation age of the big mantle wedge under eastern Asia, and the fate of the subducted Pacific slab. Integration of available data suggests that the subduction of the western Pacific plate was initiated as early as Early Jurrasic and the subduction zone was situated to 2,200 km west of the present-day trench in the Early Creataceous, as a result of eastward migration of the Asian continent over a distance of ca. 900 km since the Early Cretaceous.The retreat of the subducting west Pacific plate started ~145 Ma ago, corresponding to the initial formation of the big mantle wedge system in the Early Cretaceous. The subduction of the Pacific slab excerted severe influence on the North China Craton most likely through material and energy echange between the big mantle wedge and overlying cratonic lithosphere. The evolution history of the west Pacific plate was reconstructed based on tectonic events. This allows to propose that the causes of phases A and B for the Yanshanian orogeny were respectively related to rapid low-angle subduction and to lowering subduction angle of the west Pacific plate. At ca. 130–120 Ma, the subduction of the west Pacific plate was characterized by increasing subducting angle, slab rollback and rapid trench retreat, leading to the final stagnation of the subducting slab within the mantle transition zone. This process may have significantly affected the physical property and viscosity of the mantle wedge above the stagnant slab, resulting in non-steady mantle flows. The ingression of slab-released melts/fluids would significantly lower the viscosity of the mantle wedge and overlying lithosphere, inducing decratonization. This study yields important bearings on the relationship between the subduction of the west Pacific plate and the evolution of the lithospheric mantle beneath the North China Craton. | Rixiang ZHU Yigang XU | 2019 | Science China Earth Sciences2019，62，9： | 38 |
| 18 | SHRIMP dating of volcanic rocks from Ningwu area and its geological implications显示文摘The SHRIMP U-Pb ages are reported for two volcanic rocks from the Longwangshan and the Dawangshan formations respectively, Ningwu area, Jiangsu Province. The Dawangshan formation (NB-01) is dated at (127 3) Ma, and the Longwangshan formation (NL-01), (131 4) Ma. Besides, a few Archean zircons are also found in the Longwangshan formation, which suggests a possible Archean basement in the region. | 张旗 简平 刘敦一 王元龙 钱青 王焰 薛怀民 | 2003 | Science China Earth Sciences2003，46，8： | 34 |
| 19 | 江西井冈山地区早古生代沉积岩的地球化学特征及其对沉积环境的制约显示文摘本文研究的井冈山地区位于华夏地块中部,在早古生代寒武纪-奥陶纪时期沉积了巨厚的泥砂质韵律岩层夹碳酸盐岩和含碳岩层。它们具有较高的SiO_2(53.12%~86.37%,平均为70.16%)和Al_2O_3含量(5.43%~22.70%,平均为13.54%),高的Al_2O_3/(CaO+Na_2O)(1.36~174.6,平均为45.5)与K_2O/Na_2O比值(1.0~64.7,平均为20.4)以及低的TiO_2(0.30%~0.95%,平均为0.62%)和CaO含量(0.05%~6.05%,平均为0.63%)。它们具有与上地壳相似的微量元素和稀土元素组成,即富集大离子亲石元素和轻稀土元素,铕负异常明显。它们的主量元素、微量元素和稀土元素特征显示其沉积环境主要为被动大陆边缘浅海环境,物源区被剥蚀物质以上地壳成分为主。根据研究区内早古生代沉积物中没有蛇绿岩和火山岩、Ce异常较弱、有机碳的δ^(13)C_(org)值较低(-30.2‰~-25.4‰)、以及在沉积物中普遍发育的浅海沉积标志,如波痕、荷重模、泥砾、小型斜层理、含腕足类和腹足类等生物化石的灰岩透镜体等,认为研究区在早古生代时期不是洋盆,而是浅海-半深海或陆壳海槽,是由成冰纪时期的裂解事件,使原先的华南地块被肢解成许多次级块体(如武夷、赣中南、云开等)、各块体间成为浅海盆地的结果。 | 沈渭洲 舒良树 向磊 张芳荣 王博 | 2009 | 岩石学报2009，25，10： | 33 |
| 20 | Early J_2 basalts in SE China:Incipience of large-scale late Mesozoic magmatism显示文摘Magmatism in SE China was dormant during 204―180 Ma, but was reactivated in 180― 170 Ma (early J2), and then became more and more intensive towards the end of early Cretaceous. The small-scale early J2 magmatism is the incipience to long-term and large-scale magmatism in this region. A near east-west (EW) trend volcanic belt was distributed across south Hunan, south Jiangxi and southwest Fujian was formed during early J2 time. Along this belt from the inland toward the coast, the lithology of basalts changes from alkali into tholeiite, and the amount of erupted volcanic rocks and the proportions of rhyolites coexisting with the basalts increase. On the basis of geochemical char- acteristics of these basalts, we infer that the melting degree of source rocks and the extent of frac- tional crystallization and crustal contamination all increased whereas the depth of mantle source de- creased from the inland to the coast, which led to the variations of geological characteristics of the volcanic belt. In early J2, the western spreading Pacific plate began to subduct underneath SE China continental block, reactivating near EW trend deep fault that was originally formed during the Indos- inian event. The stress of the western spreading Pacific plate and the extent of asthenosphere up- welling increased from the inland to the coast, which is consistent with the generation and evolution of early J2 basalts. | XIE Xin1, XU Xisheng1, ZOU Haibo2, JIANG Shaoyong1, ZHANG Ming3 & QIU Jiansheng1 1. State Key Laboratory of Mineral Deposit Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Department of Earth and Space Sciences, University of California at Los Angeles, Los Angeles, CA90095-1567, USA. 3. GEMOC ARC National Key Centre, Department of Earth and Planetary Sciences, Macquarie University, Sydney, N.S.W. 2109, Australia | 2006 | Science China Earth Sciences2006，49，8： | 30 |
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