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| 1 | 尖锐湿疣临床诊疗与防治指南(一)显示文摘本指南是在中华医学会皮肤性病学分会和中国医师协会皮肤科分会领导下,由性病学组、性病亚专业委员会全体委员和中国疾病预防控制中心性病控制中心相关专家集体讨论制定,供我国皮肤科医师、全科医师以及其他相关学科医师在尖锐湿疣诊疗实践中参考。尖锐湿疣又称生殖器疣、性病疣。 | | 2015 | 中国艾滋病性病2015，21，2： | 73 |
| 2 | 人乳头瘤病毒(HPV)致宫颈癌的分子机制研究显示文摘随着宫颈癌细胞生物学和分子生物学研究的不断深入,许多研究已证实HPV感染与子宫颈癌的发生密切相关。本文就人乳头瘤病毒与子宫颈癌相关性研究进行综述。 | 崔英 胥爱辉 蔡永娥 孙晓茹 | 2008 | 现代肿瘤医学2008，16，1： | 29 |
| 3 | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China显示文摘Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. | Shuang Zhao Xuelian Zhao Shangying Hu Jessica Lu Xianzhi Duan Xun Zhang Feng Chen Fanghui Zhao | 2019 | Chinese Journal of Cancer Research2019，31，4： | 30 |
| 4 | 人乳头瘤病毒在宫颈癌发病机制中的研究进展显示文摘人乳头瘤病毒(human papillomavirus,HPV)具有高度的种属特异性,人类的皮肤黏膜是其天然宿主,HPV和其他病毒一样,通过整合到宿主细胞的细胞核内发挥其致病作用,但HPV感染有自限性,90%感染HPV的女性可以自愈。 | 薛剑侠 王玉兰 李晓旭 郭敏红 郝美峰 靳晓乐 韩利强 索玉平 | 2017 | 中国药物与临床2017，17，4： | 21 |
| 5 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 6 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 7 | Update on prevention and screening of cervical cancer显示文摘Cervical cancer is the third most common cause of cancer in women in the world. During the past few decades tremendous strides have been made toward decreasing the incidence and mortality of cervical cancer with the implementation of various prevention and screening strategies. The causative agent linked to cervical development and its precursors is the human papillomavirus(HPV). Prevention and screening measures for cervical cancer are paramount because the ability to identify and treat the illness at its premature stage often disrupts the process of neoplasia. Cervical carcinogenesis can be the result of infections from multiple high-risk HPV types that act synergistically. This imposes a level of complexity to identifying and vaccinating against the actual causative agent. Additionally, most HPV infections spontaneously clear. Therefore, screening strategies should optimally weigh the benefits and risks of screening to avoid the discovery and needless treatment of transient HPV infections. This article provides an update of the preventative and screening methodsfor cervical cancer, mainly HPV vaccination, screening with Pap smear cytology, and HPV testing. It also provides a discussion of the newest United States 2012 guidelines for cervical cancer screening, which changed the age to begin and end screening and lengthened the screening intervals. | Shaniqua L Mc Graw Jeanne M Ferrante | 2014 | World Journal of Clinical Oncology2014，5，4： | 17 |
| 8 | Cervical cancer screening in developing countries at a crossroad:Emerging technologies and policy choices显示文摘Cervical cancer(CC) represents the fourth most common malignancy affecting women all over the world and is the second most common in developing areas. In these areas,the burden from disease remains important because of the difficulty in implementing cytology-based screening programmes. The main obstacles inherent to these countries are poverty and a lack of healthcare infrastructures and trained practitioners. With the availability of new technologies,researchers have attempted to find new strategies that are adapted to low- and middle-income countries(LMIC) to promote early diagnosis of cervical pathology. Current evidence suggests that human papillomavirus(HPV) testing is more effective than cytology for CC screening. Therefore,highly sensitive tests have now been developed for primary screening. Rapid molecular methods for detecting HPV DNA have only recently been commercially available. This constitutes a milestone in CC screening in low-resource settings because it may help overcome the great majority of obstacles inherent to previous screening programmes. Despite several advantages,HPV-based screening has a low positive predictive value for CC,so that HPVpositive women need to be triaged with further testing to determine optimal management. Visual inspection tests,cytology and novel biomarkers are some options. In this review,we provide an overview of current and emerging screening approaches for CC. In particular,we discuss the challenge of implementing an efficient cervical screening adapted to LMIC and the opportunity to introduce primary HPV-based screening with the availability of point-of-care(POC) HPV testing. The most adapted screening strategy to LMIC is still a work in progress,but we have reasons to believe that POC HPV testing makes part of the future strategies in association with a triage test that still needs to be defined. | Rosa Catarino Patrick Petignat Gabriel Dongui Pierre Vassilakos | 2015 | World Journal of Clinical Oncology2015，6，6： | 16 |
| 9 | Human papillomavirus DNA and P16~(INK4A) expression in concurrent esophageal and gastric cardia cancers显示文摘AIM:To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16 INK4A protein expression.METHODS:Polymerase chain reaction was used to detect the presence of HPV type16 (HPV16).The expression of P16 INK4A protein was detected using immunohistochemistry.RESULTS:Among the CC specimens,HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA),respectively (47% vs 29%),and two of both ESCC and GCA.P16 INK4A was highly expressed in both ESCC and GCA.In the HPV-associated positive CC,higher P16 INK4A expression was observed in the GCA than in the ESCC (75% vs 25%,P < 0.05).CONCLUSION:HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA.P16 INK4A may be a screening index in the HPVassociated carcinoma of gastric cardia. | Guang-Cheng Ding,Tao Guo,Department of Gastroenterology,The First Affiliated Hospital and The Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,Henan Province,China Jing-Li Ren,Xin Song,Sheng-Li Zhou,Zong-Min Fan,LiDong Wang,Henan Key Laboratory for Esophageal Cancer Research,Department of Gastroenterology,The First Affiliated Hospital,College of Basic Medicine,Zhengzhou University,Zhengzhou 450052,Henan Province,China Fu-Bao Chang,Department of Thoracic Surgery,Linzhou Center Hospital,Linzhou 456500,Henan Province,China Ji-Lin Li,Department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456500,Henan Province,China Ling Yuan,Department of Oncoradiotherapy,Henan Province Tumor Hospital,Zhengzhou 450003,Henan Province,China Yi Zeng,Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 10 | Immune therapy for human papillomaviruses-related cancers显示文摘Human papillomaviruses(HPVs) are a large family of double strand DNA viruses comprising more than 180 types. Infection with HPV is very common and it is associated with benign and malignant proliferation of skin and squamous mucosae. Many HPVs, considered lowrisk such as HPV 6 and 11, produce warts; while highrisk viruses, such as HPVs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58, induce tumors. About 5% of all cancers in men and women are associated with HPV infection. Because there are not antiviral drugs for HPV infection, current therapies for low-risk HPV infections involve physical removal of the lesion by cryotherapy, trichloracetic acid, laser, or surgical removal. Surgical procedures are effective in the treatment of precancerous lesions, however after these procedures, many recurrences appear due to new re-infections, or to failure of the procedure to eliminate the HPV. In addition, HPV can inhibit recognition of malignant cellsby the immune system, leading to the development of cancer lesions. When this occurs, radiotherapy and chemotherapy are then used. Unfortunately, about 50% of the HPV-cancer patients still die. In the past decade, a better knowledge of the natural history of the virushost interaction and of the immune response against this viral infection has brought new therapeutic strategies geared to modulate the immune system to generate an efficient virus-specific cytotoxic response. Novel HPV protein-expressing vaccines have shown some significant clinical efficacy and systemic HPV-specific cytotoxic T cell responses. This review will describe the current status of the several therapeutic strategies used to treat HPV-induced lesions, and discuss the various new therapies now being tested. | Ricardo Rosales Carlos Rosales | 2014 | World Journal of Clinical Oncology2014，5，5： | 11 |
| 11 | 人乳头状瘤病毒的精准检测与宫颈癌防治显示文摘子宫颈癌是世界上最常见的妇科恶性肿瘤之一,在女性所有肿瘤中居第二位。在发达国家,由于定期的巴氏筛查试验和疫苗接种,发病率下降,但是在发展中国家(包括亚洲),死亡率仍达80%。 | 原亚莉 贺桂芳 卞美璐 | 2017 | 中日友好医院学报2017，31，3： | 10 |
| 12 | Cervical cancer screening:A never-ending developing program显示文摘With the term 'oncological screening', we define the overall performances made to detect early onset of tumors. These tests are conducted on a population that does not have any signs or symptoms related to a neoplasm. The whole population above a certain age, only one sex, only subjects with a high risk of developing cancer due to genetic, professional, discretionary reasons may be involved. Screening campaigns should be associated, when risk factors that can be avoided are known, with campaigns for the prevention of cancer by means of suitable behavior. The goal of cancer screening cannot however be limited to the diagnosis of a greater number of neoplasms. Screening will be useful only if it leads to a reduction in overall mortality or at least in mortality related to the tumor. Screening should then allow the diagnosis of the disease at a stage when there is a possibility of healing, possibility that is instead difficult when the disease is diagnosed at the appearance of signs or symptoms. This is the reason why not all campaigns of cancer screening have the same effectiveness. In Italy, every year there are about 150000 deaths due to cancer. Some of these tumors can be cured with a very high percentage of success if diagnosed in time. Cervical cancer can be diagnosed with non-invasive tests. The screening test used all over the world is Papanicolaou(Pap) test. This test may be carried out over the entire healthy population potentially exposed to the risk of contracting cancer. Public health has begun the screening campaigns in the hope of saving many of the approximately 270000 new cases of cancer reported each year. Screening is done following protocols that guarantee quality at the national level: these protocols are subject to change over time to reflect new realities or to correct any errors in the system. A simplified sketch of a possible route of cancer screening is as follows:(1) after selecting the target population, for example all women between 25 and 64 years(in the case of monitoring of cervical cancer), an invitation letter with the date and time of the appointment, planned according to the acceptance capacity of the hospital, is sent to all individuals;(2) an examination, which depending on the individual and the type of cancer to be monitored, for example, canbe a Pap smear, is performed and the patient can go home;(3) once available the results of examinations, if negative, they shall be communicated to the person concerned that will be notified by mail and will be recalled for a second test at a few years of distance, in the case of non-negativity, instead, the patient is contacted by telephone and informed of the need to carry out further examinations: it is said that the patient is in the 'phase two' of the screening pathway;(4) in phase two, reached by only a small portion of the interested parties(usually less than 3%-5%), more indepth tests are carried out, which, depending on the individual and the type of cancer, can be: cytological and colposcopic examinations, the removal of a fragment of tissue(biopsy) and subsequent histological examination, additional tests such as ultrasound, radiography, or others such as computerized tomography, magnetic resonance imaging, positron emission tomography, etc., in case of negativity, the concerned person will be called for new control tests at a a few years of distance, in case of non-negativity, it will be proposed instead an oncologic therapeutic plan and/or surgery to treat the diagnosed tumor; and(5) once the treatment plan is completed, the individual enters the follow-up protocol, which is monitored over time to see if the tumor has been completely removed or if instead it is still developing. Cervical cancer is undoubtedly the most successful example of a cancer screening campaign. Paradoxically, its effectiveness is one of the strongest reasons to criticize the usefulness of vaccination against human papillomavirus(HPV) in countries where the screening service with Pap test is organized in an efficient manner. Cervical cancer screening protocols are directed to sexually active women aged 25-64 years: they provide the Pap test performed by examining under a microscope or by staining with a specific 'thin prep' the material taken from the cervix with a small spatula and a brush. It is recommended to repeat the test every two or three years. It is important to emphasize that women vaccinated against HPV MUST continue the screening with Pap test. Although some screening programs(e.g., Pap smears) have had remarkable success in reducing mortality from a specific cancer, any kind of screening is free from inherent limitations. The screening methods are in fact applied to large parts of the apparently healthy population. In particular, the limits for certain cancers may be as obvious as to prohibit the introduction of an organized screening program. Potential limitations of organized screenings are basically of two types: organizational and medical. The limits of organizational type relate to the ability of a program to recruit the whole target population. Although well organized, a screening program will hardly be able to exceed a coverage of 70%-80% of the target population, and in fact the results of the current programs are often much smaller. The limits of medical type are represented by the possibility of reducing the overall mortality, or specific mortality, using a specific screening campaign. | Ciro Comparetto Franco Borruto | 2015 | World Journal of Clinical Cases2015，3，7： | 10 |
| 13 | 厦门地区女性宫颈人乳头状瘤病毒感染3155例检测结果分析显示文摘目的 探讨厦门地区门诊就诊人群宫颈人乳头状瘤病毒(HPV)感染的型别分布和年龄分布特征.方法 应用HybriMax技术,对2008年1月-2009年12月到厦门市第174医院妇科门诊就诊的3 155例有性生活女性,进行宫颈HPV基因分型检测.结果 HPV总感染率17.0%,检出高危型HPV占感染病例的72.2%,低危型HPV占15.1%,中国人群常见型HPV占12.7%;HPV亚型检出率最高的是HPV-16;3 155例HPV感染高峰年龄段在25~34岁(29.9%),其他各年龄段之间两两比较差异无统计学意义(P>0.05).结论 厦门地区门诊女性人群宫颈HPV感染率17.0%,常见型别为HPV16、52、58、18、6和68型;人群感染高峰在25~34岁年龄段. | 邱慧玲 王玲玲 沙爱国 | 2010 | 临床军医杂志2010，38，6： | 9 |
| 14 | 2015美国疾病控制中心人乳头瘤病毒感染及肛门生殖器疣治疗指南显示文摘1人乳头瘤病毒感染目前,可以确定的人乳头瘤病毒感染(human papillomavirus,HPV)大约有100种,其中至少40种可以引起生殖器感染。大多数的HPV感染具有自限性,无临床症状或没有可识别的症状。大多数性行为活跃者一生中至少感染过一次HPV。宫颈、阴茎、外阴、阴道、肛门以及口咽等部位的癌变或者癌前病变多数是由致癌的即高危HPV(例如HPV 16型和18型)感染所致; | 刘晗 柯吴坚 杨立刚 | 2015 | 皮肤性病诊疗学杂志2015，22，5： | 7 |
| 15 | Daxx和HPV16 E6在宫颈病变中的表达及其意义显示文摘目的 探讨Daxx与人乳头瘤病毒(HPV) 16 E6在宫颈病变中的表达情况及其意义.方法 对2010年9月至2013年11月就诊于中国医科大学附属盛京医院妇产科门诊活检或手术切除宫颈组织标本[其中宫颈癌63例,宫颈上皮不典型增生(CIN)Ⅲ44例,Ⅰ~Ⅱ45例,正常宫颈标本42例],采用免疫组化SABC法,检测Daxx及HPV16 F6的表达情况.结果 (1)在慢性宫颈炎、CINⅠ~Ⅱ、CINⅢ和宫颈癌中Daxx的阳性表达率分别为28.57%(12/42),40.00%(18/45),65.91%(29/44),66.67% (42/63),HPV16 E6为15.38%(6/39),36.17%(17/47),46.30%(25/54),100.00%(24/24);二者在宫颈高度病变组表达高于低级别组(P<0.05).(2) HPV16 F6高表达组的Daxx表达率高于HPV16 E6低表达组(P<0.05).(3) Daxx的表达与宫颈癌的病理分级、临床分期、淋巴结转移情况及患者年龄无关(P>0.05).(4) Daxx与HPV16 E6的阳性表达呈正相关(r=0.695,P<0.05).结论 Daxx和HPV16 E6随着宫颈病变级别的升高表达增加,两者可能存在某种协同作用,可能对宫颈病变发展起促进作用. | 周蕾 张慧杰 黄成琳 庞晓奡 张淑兰 | 2015 | 中华医学杂志2015，95，37： | 6 |
| 16 | 鼻腔鼻窦非角化性鳞状细胞癌的临床病理学特征显示文摘目的:探讨鼻腔鼻窦非角化性鳞状细胞癌的临床病理学特征、免疫表型特点及诊断与鉴别诊断。方法收集441例鼻腔鼻窦鳞状细胞癌,选取其中26例非角化性鳞状细胞癌患者的临床及病理检查资料,观察其组织形态学特点,采用免疫组织化学EnVision法对20例行广谱细胞角蛋白( CKpan)、波形蛋白、CK5/6、CK7、CK8/18、p16、p53、Ki-67等多种标志物染色;以导流杂交等方法检测人乳头状瘤病毒(HPV),以原位杂交方法检测EB病毒编码小mRNA1/2(EBER),以RNAscope方法检测其肿瘤组织内HPV mRNA。结果患者年龄22-79岁,平均年龄51.2岁,男16例,女10例,男女比为8∶5,3例患者有内翻性乳头状瘤的病史。镜下肿瘤组织主要呈乳头状和内翻浸润性生长,似尿路上皮乳头状癌形态;浸润生长部分形成大小不一的实性细胞巢,肿瘤细胞核大圆形,核仁明显,2例可见部分肿瘤细胞呈梭形,1例可见与鼻腔鼻窦被覆纤毛柱状上皮有移行。免疫组织化学染色结果示CKpan及p63(20/20)均为弥漫强阳性;CK5/6在17例为弥漫强阳性,3例为部分阳性;CK8/18在16例弥漫强阳性,3例灶状阳性,1例阴性;CK7在7例弥漫强阳性,13例阴性;波形蛋白在2例部分阳性,18例阴性;p16在1例弥漫强阳性,19例阴性;p53在19例阳性;Ki-67有11例阳性表达超过50%,其他神经内分泌标志物及黑色素瘤标志物为阴性。导流杂交方法检测到1例HPV (6、11、16、18)为阳性,进一步行HPV原位杂交检测,其HPV16/18及6/11阳性,用RNAscope技术检测,结果显示肿瘤组织中HPV18 mRNA阳性。20例EBER原位杂交均呈阴性。本组病例多为5年之内病例,预后有待于进一步随访观察。结论鼻腔鼻窦非角化性鳞状细胞癌是一种罕见的、具有明显形态学特征的上皮性恶性肿瘤,以发生部位、组织学特点为主要诊断依据,免疫组织化学染色标志物可辅助诊断及鉴别诊断;肿瘤可能起源于鼻腔鼻窦被覆纤毛柱状上皮,与HPV及EB病毒感染相关性不明显。 | 赵艺哗 刘红刚 | 2016 | 中华病理学杂志2016，45，9： | 6 |
| 17 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 18 | FRD上皮组织特殊染色液筛查宫颈病变的应用研究显示文摘为了研究FRD上皮组织特殊染色液筛查宫颈病变的应用,本研究选取2014年1月到2015年8月于我院和中山大学附属第一医院就诊的妇科患者,FRD染色检查宫颈病变,共500例为研究对象。所有患者进行FRD染色,同时进行TCT及HPV DNA检测。进一步行阴道镜检查的指证为三者任意一项异常,若患者宫颈外口异常,则于该处组织活检,活检过程中严格根据阴道镜结果。结果表明本组500例患者中,FRD检测结果阳性324例,阴性176例;阴道镜检测结果表明,阳性宫颈炎症111例,CINⅠ159例,CINⅡ45例,CINⅢ9例;FRD与阴道镜病理检测结果符合率为78.34%。TCT检测结果 NILM 184例,ASCUS 170例,ASCUS-H 77例,LSIL50例,HSIL 19例;TCT检测与阴道镜病理检测结果符合率为54.89%。HPV检测结果阳性258例,阴性242例;阴道镜检测结果表明,阳性宫颈炎症111例,CINⅠ159例,CINⅡ45例,CINⅢ9例;FRD与阴道镜病理检测结果符合率为62.30%。病变诊断中,HPV | 李开颜 蔡海莹 沈慧敏 | 2016 | 基因组学与应用生物学2016，35，7： | 5 |
| 19 | Prevalence and Determinants of High-risk HPV Infection among 11549 Women from an Opportunistic Screening in Hubei Province显示文摘High-risk human papillomavirus (hrHPV) infection plays an important role in the development of cervical intraepithelial neoplasia and cervical cancer.A total of 11 549 women were enrolled from the Maternal and Child Health Hospital of Hubei Province.Each participant accepted hrHPV testing and completed a self^administered questionnaire about basic information and potential risk factors.The univariable and multivariable logistic regression model was used to explore the associations between variants and hrHPV infection.Our results showed that hrHPV prevalence was 16.09% in Hubei Province,among which,hrHPV was more likely to be positive in women aged 51 years or above (OR=1.65,95% CI:1.28-2.14),and in women who had symptoms of bleeding after intercourse (OR=1.32,95% CI:1.17-1.50),had first sexual intercourse at the age of 18 years or below (OR=1.33,95% CI:1.07-1.64),had at least three male sexual partners (OR=2.50,95% CI:2.07-3.03),and who had been diagnosed with sexually transmitted infections (OR=1.50,95% CI:1.12-2.03).Married women (OR=0.66,95% CI:0.55-0.78) and women who frequently used condoms (OR=0.75,95% CI:0.67-0.84) had a relatively lower hrHPV prevalence.This study confirms that hrHPV infection was associated with age,marital status,symptoms of intercourse bleeding,history of sexually transmitted infections,and sex-related behaviors.Above all,this study provides a baseline database prior to obtaining vaccinations for dynamic tracking of the changes in hrHPV prevalence. | Quan-fu MA Yu-lin GUO Han GAO Bin YAN Xuan DAI Meng XU Yu-jing XIONG Qiu-zi PENG Ying WANG Miao ZOU Xu-feng WU | 2019 | Current Medical Science2019，39，4： | 5 |
| 20 | Human papillomavirus and gastrointestinal cancer: A review显示文摘Human papillomavirus(HPV) is one of the most common sexually transmitted infections worldwide. Exposure to HPV is very common,and an estimated 65%-100% of sexually active adults are exposed to HPV in their lifetime. The majority of HPV infections are asymptomatic,but there is a 10% chance that individuals will develop a persistent infection and have an increased risk of developing a carcinoma. The International Agency for Research on Cancer has found that the following cancer sites have a strong causal relationship with HPV: cervix uteri,penis,vulva,vagina,anus and oropharynx,including the base of the tongue and the tonsils. However,studies of the aetiological role of HPV in colorectal and esophageal malignancies have conflicting results. The aim of this review was to organize recent evidence and issues about the association between HPV infection and gastrointestinal tumours with a focus on esophageal,colorectal and anal cancers. The ultimate goal was to highlight possible implications for prognosis and prevention. | Dania Bucchi Fabrizio Stracci Nicola Buonora Giuseppe Masanotti | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
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