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| 1 | Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma显示文摘AIM:To investigate the function of Pea3 in colorectal carcinoma(CRC)invasion and metastatic potential.METHODS:The expression of Pea3 during clinical progression of human CRC was investigated using Oncomine Research Edition.To assay Pea3 expression in established CRC cell lines,we performed western blotting of cell lysates.We employed sh RNA-mediated knockdown of Pea3 in HCT116(HCT)and LS174T CRC cells which was confirmed by real-time quantitative PCR(q PCR)and western blotting.Transwell invasion assays,MTS proliferation assays,anoikis assays,and fluorometric matrix metalloprotease(MMP)assays wereperformed to determine the effects of Pea3 knockdown on invasion,proliferation,anoikis and MMP activity in CRC cells in vitro.Alterations in epithelial-mesenchymal transition(EMT)and matrix metalloprotease(MMP)m RNA levels were determined by q PCR.CRC cells were injected into the flanks of nude mice to generate xenografts and tumor growth monitored with serial calliper measurements.To assay metastatic potential,CRC cells were injected into the spleen of nude mice,and histological analysis performed on the livers 21 d later.RESULTS:We demonstrated that reduction of Pea3expression in CRC cells significantly impaired their invasive capacity(HCT.sh Pea3,0.28±0.04 fold,P<0.01;LS.sh Pea3,0.15±0.04 fold;SW.sh Pea3,0.23±0.03,P<0.01),reduced anoikis resistance(HCT.sh Pea3 75.4%±1.9%viable cells vs HCT.sh Ctrl 88.6%±0.6%viable cells,P<0.01;LS.sh Pea3 71.7%±0.5%viable cells vs LS.Ctrl 89.6%±0.3%viable cells,P<0.005,but had no effect on proliferation(HCT.sh Ctrl AUC 5098±123 vs HCT.sh Pea3 5689±151,P<0.05;LS.sh Ctrl AUC 5600±324.1 vs LS.sh Pea3 6423±400,P<0.05).In vivo,HCT.sh Pea3 and HCT.sh Ctrl tumour xenografts grew at a similar rate(HCT.sh Pea3 2.64±0.82 fold vs HCT.sh Ctrl 2.88±0.80 fold,P>0.05).In keeping with a pro-metastatic function for Pea3 in CRC,several EMT markers and MMPs were downregulated in sh Pea3-expressing cells,suggesting that Pea3 may exert its effects through these processes.A reduction in overall MMP activity was observed in HCT.sh Pea3 cells compared to their control counterparts(HCT.sh Pea30.61±0.04 fold,P<0.005).This translated in vivo to the complete absence of metastases in the livers of mice that were grafted with CRC cells lacking Pea3.Conversely,CRC cells expressing Pea3 formed liver metastases in all mice.CONCLUSION:Our study implicates Pea3 as a mediator of metastases,and provides a biological rationale for the adverse prognosis associated with elevated Pea3 expression in human CRC. | Aruz Mesci Samira Taeb Xiaoyong Huang Rishi Jairath Darshan Sivaloganathan Stanley K Liu | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 2 | Outcome of transarterial chemoembolization-based multi-modal treatment in patients with unresectable hepatocellular carcinoma显示文摘AIM:To investigate the efficacy and safety of transarterial chemoembolization(TACE)-based multimodal treatment in patients with large hepatocellular carcinoma(HCC).METHODS:A total of 146 consecutive patients were included in the analysis,and their medical records and radiological data were reviewed retrospectively.RESULTS:In total,119 patients received TACE-based multi-modal treatments,and the remaining 27 received conservative management.Overall survival(P<0.001)and objective tumor response(P=0.003)were significantly better in the treatment group than in the conservative group.After subgroup analysis,survival benefits were observed not only in the multi-modal treatment group compared with the TACE-only group(P=0.002)but also in the surgical treatment group compared with the loco-regional treatment-only group(P<0.001).Multivariate analysis identified tumor stage(P<0.001)and tumor type(P=0.009)as two independent pre-treatment factors for survival.After adjusting for significant pre-treatment prognostic factors,objective response(P<0.001),surgical treatment(P=0.009),and multi-modal treatment(P=0.002)were identified as independent post-treatment prognostic factors.CONCLUSION:TACE-based multi-modal treatments were safe and more beneficial than conservative management.Salvage surgery after successful downstaging resultedin long-term survival in patients with large,unresectable HCC. | Do Seon Song Soon Woo Nam Si Hyun Bae Jin Dong Kim Jeong Won Jang Myeong Jun Song Sung Won Lee Hee Yeon Kim Young Joon Lee Ho Jong Chun Young Kyoung You Jong Young Choi Seung Kew Yoon | 2015 | World Journal of Gastroenterology2015，21，8： | 7 |
| 3 | 低压轴向双分裂变压器半穿越状态下绕组电流及温升计算显示文摘利用Magnet软件以及经典理论公式,分别对半穿越运行状态下高压绕组上、下两个支路的电流进行了计算,利用TranCalc软件对该工况下绕组温升进行了计算,并与试验数据进行了对比。 | 谈翀 胥建文 徐莲环 张晓阳 张凯 | 2017 | 变压器2017，54，6： | 5 |
| 4 | 正在走向世界的中国城轨交通显示文摘在会员单位的动议下,中国城市轨道交通协会决定携手北车集团、南车集团、铁道科学院联合其他参展单位共同筹建'中国馆',组织'中国馆日'活动。9月,世界最大的轨道交通展览会——柏林轨道交通展览会就要揭幕了,届时全世界的轨道交通从业者都将汇聚柏林,共襄两年一度的盛大聚会。伴随着中国轨道交通的快速发展,中国企业、中国品牌、中国技术。 | 包叙定 | 2014 | 城市轨道交通2014，，3： | 4 |
| 5 | A Study of the Functional Equivalence Theory in the Business Letter Translation显示文摘' Functional Equivalence Theory' , including Dynamic Equivalence and Formal Equivalence two parts, was first put forward by an American translator , Nida, Eugene A. This theory makes it available for readers of translation feel the same way as those of the origi nal. This theory has become the highest standard in Business Letter Translation in consideration of features of business letters, like normaliz ing, pries word, sample pattern, tactful tone, and its different functions like providing information, communicating and so on. However, be cause of the differences between Chinese culture and foreign cultures, there are some situations need special treatments. This paper does some study in the Functional Equivalence Theory and its application in Business Letter Translation. Finally, the paper educe the conclusion as: This theory has feasibility and constructive function in Business Letter Translation. However, this theory should be abounded and im proved ceaselessly in practice, since it still have some shortages. | 张颖 | 2012 | 海外英语2012，，10X： | 3 |
| 6 | The Manipulation of Poetic and Ideology: Human Translation in Sour Sweet显示文摘Timothy Mo,a famous British writer whose works have won many important prizes,experiences both Chinese culture and English culture since his childhood.Due to this kind of experience,his works are usually concerned with the issue of cultural conflict.Among these works,Sour Sweet is the most well-known one in China,and it has also been filmed as Soursweet in 1988 with the famous actress Zhang Aijia.In Sour Sweet,Timothy Mo tells a story about a Chinese family’s struggle in the UK.After experiencing a serious of cultural conflict,among the three family members Chen,Lily and Mui,only Lily achieves a delicate balance.After defining the process of establishing oneself in a new environment as a kind of human translation,the article applies AndréLefevere’s theory to study the three characters’different responses to the cultural conflict,analyze how different poetic and different strategies adopted to deal with ideology affect their translation,explain why does or doesn’t he/she translates himself/herself successfully,and finally gets the conclusion:because Lily deals well with the dominant ideological and poetical currents,and makes appropriate choice in face of cultural translatability and untranslatability,so only she can translate herself successfully. | 刘金龙 | 2015 | 海外英语2015，，16： | 1 |
| 7 | “态”简单显示文摘手术灯'啪'的全亮了,冰冷的灯光下医生淡定地拿出了麻药针,这一针让我的脚微微感到刺痛,我躺在手术椅上看不到脚那头的情况,变得更加紧张。'T hat was the worst.'身旁的护士温柔地对我说道。此刻护士的话让我心头一惊:'她用的是过去时!T hat是说那针麻药,was是过去时。刚才那针是最痛的!'但这是真的吗?我想只有两种可能:一是护士是在安抚我,二是护士说的是实话。看着护士温柔的表情,我选择了相信她。接下来我听到脚那头医生拿放剪刀等各式手术工具发出的金属碰撞声,但脚上却什么感觉都没有。 | 吴以焕 | 2015 | 新东方英语(中学版)2015，0，12： | 0 |
| 8 | Native Culture Issues in Cross-cultural Teaching显示文摘The bi-direction of cross-cultural communication determines culture teaching should include both target culture and native culture.Currently,however,mere emphasis of target culture with ignoring native culture has resulted in 'two-skin'phenomenon and'aphasia of Chinese culture'.Therefore,this paper aims to underline native culture teaching,to explore proper techniques for native culture teaching,to achieve integration of target culture and native culture,to enhance studentséxpressive competence in native culture and finally to carry out effective cross-cultural communication. | 万欣 | 2012 | 海外英语2012，，22： | 0 |
| 9 | Sapir-Whorf Hypothesis and Translation显示文摘Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a kind of interlingual and intercultural communication. It involves not only the transference from one language into another, but a whole set of extra-linguistic criteria. In translating we are always crossing a greater or lesser barrier or divide. | 姜海清 | 2013 | 海外英语2013，，5X： | 0 |
| 10 | On How to Translate English Figures of Speech-Simile and Metaphor into Chinese显示文摘This paper is going to use some examples to illustrate how to translate English figures of speech-simile & metaphor into Chinese. | 朱久堂 | 2015 | 校园英语2015，，30： | 0 |
| 11 | Time-crystal ground state and production of gravitational waves from QCD phase transition显示文摘We propose a novel mechanism for the production of gravitational waves in the early Universe that originates from the relaxation processes induced by the QCD phase transition. While the energy density of the quark-gluon mean-field is monotonously decaying in real time, its pressure undergoes a series of violent oscillations at the characteristic QCD time scales that generate a primordial multi-peaked gravitational waves signal in the radio frequencies’ domain. The signal is an echo of the QCD phase transition that is accessible by planned measurements at the FAST and SKA telescopes. | Andrea Addazi Antonino Marcianò Roman Pasechnik | 2019 | Chinese Physics C2019，43，6： | 0 |
| 12 | Translation Principles and Methods for Long Sentences in English Sale Contracts of Goods显示文摘The translation of English sale contracts of goods has become an important step in international goods sales. In order to resolve the difficulties, the translation of long sentences, the author defines what the translation of English sale contracts of goods is in the international goods sales based on skopos theory. Then the author presents four principles: accuracy, fluency, standard and preciseness for the translation of long sentences in view of the purpose of translation, the nature of readership and the type of texts. And the author further advances feasible methods for the translation of long sentences after analyzing their features. These principles and methods are proven to be meaningful in the translation of English sale contracts of goods. | 万浩 | 2012 | 海外英语2012，，2X： | 0 |
| 13 | Liver transplantation and sleeve gastrectomy in the medically complicated obese: New challenges on the horizon显示文摘In the last 30 years, operative, technical and medical advances have made liver transplantation(LT) a lifesaving therapy that is used worldwide today. Global industrialization has been a contributor to morbid obesity and this has brought about the metabolic syndrome along with many downstream complications of such. Non-alcoholic steatohepatitis(NASH) has become a recognized hepatic manifestation of the metabolic syndrome and NASH cirrhosis is predicted to be the primary indication for LT in the United States by 2025. Several case series and database reviews have begun analyzing the efficacy of weight reduction surgery in the LT recipient. These data have reasonably demonstrated that weight reduction surgery in the LT recipient is a feasible endeavor. However, several questions have been raised regarding the type of weight reduction surgery, timing of surgery in relation to LT, patient and allograft survival and post-LT maintenance of weight loss to name a few. We look forward to a time when weight reduction surgery will work to improve the technical conduct of LT, improve perioperative benchmarks such as blood transfusions, intensive care unit length of stay and help to prevent recurrence of NASH cirrhosis in the medically complicated obese patient. In the meantime, well-designed prospective clinical trials that focus on the issues highlighted will help guide us in the care of these complicated patients who will soon account for the majority of the patients in our clinics. | Diego C Reino Keri E Weigle Erik P Dutson Adam S Bodzin Keri E Lunsford Ronald W Busuttil | 2015 | World Journal of Hepatology2015，7，21： | 0 |
| 14 | On the Features and Functions of Film Titles and Relevant Translation显示文摘Film is an art manifestation which originated from daily life.Besides it is also a mental product conveyed with various kinds of cultural,political,ideological elements.Film title,as the name card to a film,is short in form but rich in meaning,has its own linguistic,cultural,aesthetic and commercial features.Film title translation is a unique field of translation practice but far less explored.In this essay,the author tries to explain the features and functions of film title with cases and provides a scan of film title translation study at home in order to assist translators to find the major difficulties in film title translation and to improve the overall quality of film title translation in the market. | 徐璐 | 2014 | 海外英语2014，，4X： | 0 |
| 15 | The Application of Wang Rongpei's Translation Strategies in Translating Chinese Ancient Poetry显示文摘Professor Wang Rongpei has put forward the translation principle—'faithful in meaning and vivid in description'and put it into use. Through a series of analysis and contrast of different versions, this essay would prove the rationality of Professor Wang Rongpei's translation principle. | 张亚楠 马玉梅 | 2014 | 海外英语2014，，4X： | 0 |
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