|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 旅游文化纪念品意象传达与符码转换设计研究显示文摘目的进行意象传达与符码转换在旅游文化纪念品设计中的应用研究。方法通过研究文化的组成方式、旅游文化纪念品的意象信息传达方式以及目前旅游文化纪念品在设计过程中所运用到的意象符码转换方法,提出将文化意涵搭载于纪念品中的'8 TRANS'旅游文化纪念品设计方法。以台湾兰屿乡为例,使用'8 TRANS'方法指导其旅游文化纪念品设计。结论依据基于意象传达与符码转换理论设计的旅游文化纪念品,较好地体现了地域文化特色,为旅游文化纪念品的设计研究提供了可供借鉴的思路与方法。 | 段晓赛 赵锋 张倩 付怡 | 2016 | 包装工程2016，37，22： | 11 |
| 2 | Interventions to improve sarcopenia in cirrhosis: A systematic review显示文摘BACKGROUND Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.AIM To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt(TIPS) to improve muscle mass in cirrhosis.METHODS We search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles(RCTs, clinical trial, comparative study)in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.RESULTS We identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements.We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.CONCLUSION Although the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings. | Maliha Naseer Erica P Turse Ali Syed Francis E Dailey Mallak Zatreh Veysel Tahan | 2019 | World Journal of Clinical Cases2019，7，2： | 8 |
| 3 | Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?显示文摘AIM: To evaluate transient elastography(TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver diseases.METHODS: A total of 90 children [50 with chronic hepatitis C virus(HCV), 20 with autoimmune hepatitis(AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement(LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction(FAF) using digital image analysis(morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was alsoperformed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiveroperating characteristic curve. Cut-off values with optimal clinical performance(optimal sensitivity and specificity simultaneously) were selected.RESULTS: The majority of HCV group had minimal activity(80%) and no/mild fibrosis(72%). On the other hand, the majority of AIH group had mild to moderate activity(70%) and moderate to severe fibrosis(95%) and all Wilson disease group had mild to moderate activity(100%) and moderate to severe fibrosis(100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter(r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH(16.15 ± 7.23 k Pa) compared to Wilson disease(8.30 ± 0.84 k Pa) and HCV groups(7.43 ± 1.73 k Pa). Multiple regression analysis revealed that Ishak fibrosis stage was the only independent variable associated with higher LSM(P < 0.0001).CONCLUSION: TE appears reliable in distinguishing different stages of liver fibrosis in children. However, its values vary according to the disease type. For that, a disease-specific estimation of cut-off values for fibrosis staging is worthy. | Behairy El-Sayed Behairy Mostafa Mohamed Sira Khaled Refat Zalata El-Sayed Ebrahem Salama Mohamed Ahmed Abd-Allah | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 4 | Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression显示文摘AIM:To investigate the effect of hypoxia or hyperoxia on the progression of hepatic fibrosis and to examine the role of transforming growth factor-β(TGF-β)in the livers of rats exposed to hypoxic or hyperoxic conditions.METHODS:Male Sprague-Dawley rats were injected intraperitoneally with thioacetamide to induce hepatic fibrosis and were randomly divided into a hypoxia group,a hyperoxia group and an untreated control group.Ten rats in the hypoxia group were exposed to an altitude of 20000 ft for 1 h/d during 7 wk.Ten rats in the hyperoxia group were exposed to a water depth of 20 m with 100%oxygen supply for 1 h/d during 7wk.We evaluated the degree of hepatic fibrosis using Masson trichrome stain and examined the expression level of hepatic TGF-βmRNA using quantitative realtime reverse transcriptase-polymerase chain reaction analysis.RESULTS:Eight of 10 rats exposed to hypoxia showed diffuse and confluent fibrosis with the formation of structurally abnormal parenchymal nodules involving the entire liver,consistent with hepatic cirrhosis.Nine of 10 rats exposed to hyperoxia also demonstrated obvious histological findings of hepatic cirrhosis identical to those in hypoxic rat livers.In contrast,8 of 10untreated rats had periportal or septal fibrosis only.The frequency of hepatic cirrhosis in hypoxic rats(P=0.009)and hyperoxic rats(P=0.003)was significantly higher than that in untreated rats.In addition,hepatic TGF-βmRNA levels in hyperoxic rats were significantly higher than those in untreated rats.The mean value of the normalized TGF-βmRNA/β-actin expression ratio in the hyperoxic rats was 1.9-fold higher than that in the untreated rats(P=0.027).CONCLUSION:We demonstrated that both hypoxia and hyperoxia accelerated the progression of hepatic fibrosis in rats.Significant up-regulation of hepatic TGF-βin hyperoxic rats suggests that TGF-βis involved in the acceleration of hepatic fibrosis under hyperoxic conditions. | Sang Hwa Lee Sung-Im Do Hyun-Soo Kim | 2014 | World Journal of Gastroenterology2014，20，11： | 6 |
| 5 | All-trans retinoic acid reduces intimal thickening after balloon angioplasty in atherosclerotic rabbits显示文摘Percutaneoustransluminalbaloonangioplasty(PTCA)hasbecomeawelestablishedtherapyinthemanagementofcoronaryarterydisease.However... | 陈继远 何奔 郑道声 张世华 刘建平 朱顺和 | 1999 | Chinese Medical Journal1999，，2： | 5 |
| 6 | Trans Complementation of Replication-defective Omsk Hemorrhagic Fever Virus for Antiviral Study显示文摘Omsk hemorrhagic fever virus(OHFV) is a tick-borne flavivirus classified as a biosafety level-4(BSL4) pathogen. Studies of OHFV are restricted to be conducted within BSL4 laboratories. Currently, no commercial vaccines or antiviral drugs are available against OHFV infection. In this study, we recovered a replication-deficient OHFV with an NS1 deletion(OHFVDNS1) and reporter virus replacing NS1 with the Gaussia luciferase(Gluc)(OHFV-ΔNS1-Gluc). Both the defective OHFVDNS1 and OHFV-ΔNS1-Gluc virus could only replicate efficiently in the BHK21 cell line expressing NS1(BHK21NS1) but not in na?ve BHK21 cells. The Gluc reporter gene of OHFV-ΔNS1-Gluc virus was maintained stably after serial passaging of BHK21NS1 cells and was used to surrogate the replication of OHFV. Using NITD008, OHFV-ΔNS1-Gluc virus was validated for antiviral screening, and high-throughput screening parameters were optimized in a 96-well plate format with a calculated Z0 value above 0.5. The OHFV-ΔNS1-Gluc reporter virus is a powerful tool for antiviral screening as well as viral replication and pathogenesis studies in BSL2 laboratories. | Qiuyan Zhang Na Li Chenglin Deng Zherui Zhang Xiaodan Li Kentaro Yoshii Hanqing Ye Bo Zhang | 2019 | Virologica Sinica2019，34，4： | 4 |
| 7 | Mechanism of inhibition on activator protein 1 activity by all trans retinoic acid in gastric cancer cells显示文摘To determine the mechanism of all trans retinoic acid (ATRA) on growth inhibition in human gastric cancer cells Methods Gastric cancer cell lines: MGC80 3, BGC 823, SGC 7901 and MKN 45 CAT assay, Northern blot, Western blot, gene transfection and MTT assay Results ATRA can inhibit the activator protein 1 (AP 1) activity in ATRA sensitive cell lines, but not in ATRA resistant cell line, and the anti AP 1 activity of ATRA is mediated by its receptor, retinoic acid receptor α (RARα) ATRA can also inhibit the expression of cJun and cFos One of the mechanisms for ATRA to inhibit the growth of gastric cancer cells may be through its inhibitory effect on the AP 1 activity and its influence on up regulation of RARα expression The inhibition of cJun and cFos expressions by ATRA may also contribute to the anti AP 1 activity Conclusions ATRA inhibits the growth of gastric cancer cells through the regulation of AP 1 activity This action is mediated by | 吴乔 陈正明 苏文金 | 2000 | Chinese Medical Journal2000，，11： | 4 |
| 8 | trans C_(18:1)通过NOS-NO系统诱导内皮细胞损伤研究显示文摘为了观察trans C18:1对人脐静脉内皮细胞损伤的影响及其与NOS-NO系统的关系,首先将不同浓度trans C18:1(50、100、200、400μmol/L)与人脐静脉内皮细胞共培养24或48h后,MTT法检测细胞存活率;用trans C18:1(200μmol/L)处理内皮细胞24h后,分别检测一氧化氮含量(NO)及一氧化氮合酶(NOS)活性;将trans C18:1与一氧化氮合酶阻断剂亚硝酸左旋精氨酸甲酯(LNAME)及一氧化氮供体(SNP)单一或联合处理内皮细胞,检测细胞存活率的变化。结果显示:trans C18:1以剂量和时间依赖方式导致内皮细胞的存活率下降;LNAME与trans C18:1联合处理内皮细胞后细胞存活率下降,而SNP与trans C18:1联合处理后细胞存活率上升;trans C18:1可诱导NO水平和内皮型一氧化氮合酶(eNOS)活性显著下降,而诱导型一氧化氮合酶(iNOS)活性无显著改变。表明:trans C18:1能通过抑制eNOS活性减少NO的分泌,并暗示NOS-NO系统可能是trans C18:1诱导内皮细胞损伤的作用机制之一。 | 邱斌 刘蓉 邓泽元 范亚苇 李静 胡蒋宁 黎玉 | 2011 | 食品科学2011，32，15： | 4 |
| 9 | Management of early hepatic artery occlusion after liver transplantation with failed rescue显示文摘Hepatic artery thrombosis is a serious complication after liver transplantation which often results in biliary complications, early graft loss, and patient death. It is generally thought that early hepatic artery thrombosis without urgent re-vascularization or retransplantation almost always leads to mortality, especially if the hepatic artery thrombosis occurs within a few days after transplantation. This series presents 3 cases of early hepatic artery thrombosis after living donor liver transplantation, in which surgical or endovascular attempts at arterial re-vascularization failed. Unexpectedly, these 3 patients survived with acceptable graft function after 32 mo, 11 mo, and 4 mo follow-up, respectively. The literatures on factors affecting this devastating complication were reviewed from an anatomical perspective. The collective evidence from survivors indicated that modified nonsurgical management after liver transplantation with failed revascularization may be sufficient to prevent mortality from early hepatic artery occlusion. Re-transplantation may be reserved for selected patients with unrecovered graft function. | Chih-Yang Hsiao Cheng-Maw Ho Yao-Ming Wu Ming-Chih Ho Rey-Heng Hu Po-Huang Lee | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 10 | Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells显示文摘The objective of this study was to determine how cytosolic triacylglycerols(TAG) are stored in mammary cells and whether this depends on the individual chemical configuration of fatty acids(FA). This objective was accomplished by addition of different FA to a FA-free medium used to culture mammary alveolar cells-large T antigen cells(MAC-T). Treatments consisted of adding FA(palmitate, stearate, oleate, linoleate,rumenic acid [CLA], elaidate and vaccinate) solutions to the medium at 100, 200, 300 and 400 mmol/L concentrations for a 24-h incubation period. At the end of each incubation period, cytosolic TAG, DNA and protein contents were measured. Palmitate, vaccenate, linoleate and CLA increased(P < 0.05) cytosolic TAG(μg/mg protein). Palmitate and CLA increased(P < 0.05) cytosolic TAG adjusted for DNA content. Overall, effects on cytosolic TAG accumulation depended on individual FA structure(chain length, degree of saturation, and number and orientation of FA double bonds). In addition, the long-chain FA used in this study did not have a detrimental effect on MAC-T cells as indicated by cytosolic protein and DNA contents reflecting their biological role in lipid accumulation. | Einar Vargas-Bello-Pérez Juan J.Loor Philip C Garnsworthy | 2019 | Animal Nutrition2019，，2： | 2 |
| 11 | 基于公交车的多车型动态路阻函数建模与仿真显示文摘目前动态路阻函数是统一的,未考虑不同车型的具体运行情况,而公交车是城市交通中的特殊交通工具,对城市交通可持续发展起重要作用。在考虑所有车型的基础上,重点分析公交车在实际交通中的运行情况,以目前动态路阻函数为基础,针对公交车运行的四种交通情况,分别构建相应的动态路阻函数模型。并以淄博市张店区内相应路段高峰时段的交通流量为例,通过Trans Modeler建立相应的仿真进行试验验证,分析结果表明:改进的基于公交车的多车型动态路阻函数可行,其计算值比原动态路阻函数模型计算值更接近仿真结果。 | 张俊友 宋博文 | 2014 | 公路2014，59，1： | 2 |
| 12 | Effect of all-trans retinoic acid on growth of xenograft tumor and its metastasis in nude mice显示文摘Objective To study the effect of all trans retinoic acid on growth of xenograft tumor and its metastasis in nude mice Methods Human gastric cancer BGC 823 and MKN 45 cells were inoculated into spleen subcapsule of nude mice, respectively The nude mice were subsequently administered with all trans retinoic acid every other day Food consuming and body weight of nude mice were measured weekly Six weeks later, the nude mice were killed Xenograft tumors in spleen and metastatic tumors in liver were pathologically examined Microvessel density in the tumors was detected immunohistochemically, and serum carcinoembryonic antigen was measured by radioimmunoassay Results After the nude mice were fed with all trans retinoic acid, the growth of splenic tumor and its liver metastasis were inhibited and the metastatic rates decreased by 50% (BGC 823) and 33 3% (MKN 45), respectively The microvessel density in splenic and hepatic tumors reduced by 28 58% and 35 47% (BGC 823), 19 45% and 14 52% (MKN 45), respectively The concentration of carcinoembryonic antigen decreased by 50 24% (BGC 823) and 48 10% (MKN 45) Conclusion All trans retinoic acid may effectively inhibit the growth of xenograft tumor in spleen and its metastasis to liver in nude mice, which can be corroborated by the decrease of carcinoembryonic antigen and microvessel | 陈玉强 吴乔 陈正明 陈福 苏文金 | 2000 | Chinese Medical Journal2000，，4： | 2 |
| 13 | 反式C18:1对血管内皮细胞损伤的影响显示文摘目的通过检测相关细胞损伤指标,探讨trans C18:1对血管内皮细胞的损伤机制。方法体外细胞培养方法将含trans C18:1终浓度分别为0、50、100、200、400、600μmol/L的达氏修正依氏培养基(DMEM)与血管内皮细胞(EC)于37℃、5%CO2共同孵育24~48 h后,分别测乳酸脱氢酶(LDH)活性和一氧化氮(NO)含量及细胞中一氧化氮合酶(NOS)活性,采用单四唑(MTT)法计算trans C18:1对EC作用后细胞存活率的变化。结果 EC的存活率下降。随时间的延长,与trans C18:1的浓度呈剂量依赖关系;NO分泌量和NOS活性的下降及LDH渗出率的升高与trans C18:1浓度呈剂量依赖关系。Trans C18:1的各浓度梯度与对照组比,以上指标都有显著性差异。结论 transC18:1可造成血管内皮损伤。 | 邱斌 刘蓉 邓泽元 范亚苇 李静 胡蒋宁 | 2010 | 营养学报2010，32，4： | 2 |
| 14 | Combination of al-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB_4 cells显示文摘ObjectiveTouseNB4,anauthentichumanacutepromyelocyticleukemiacelline,aswelasthemarowcelsfrompatientswithacutepromyelocyticleuk... | 陈子兴 王玮 潘金兰 陈丽娟 薛永权 | 1999 | Chinese Medical Journal1999，，4： | 2 |
| 15 | Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells显示文摘study the effect of all trans retinoic acid (ATRA) and arsenic trioxide (As 2O 3) on tissue factor (TF) expression and procoagulant activity (PCA) of acute promyelocytic leukemia (APL) cells in vivo and in vitro Methods PCA from freshly isolated APL blasts from APL patients treated with ATRA or As 2O 3 was detected using a one stage clotting assay TF antigen was detected by ELISA and TF mRNA by RT PCR The maturation sensitive (NB4) or resistant subclones (NB4 R1) of the promyelocytic NB4 cell line, as well as U937 cells infected with pMSCV PML RARa treated with or without ATRA or As 2O 3, were also examined Results Both ATRA and As 2O 3 can down regulate the TF antigen, its mRNA transcription and membrane PCA of APL cells in vivo and in vitro, in a time dependent manner The TF antigen level in PML RARa+ U937 cells was significantly higher than that in U937 cells infected with retrovirus vector Both ATRA and As 2O 3 can also down regulate the TF antigen in U937 cells transfected with or without PML RARa Conclusion Tissue factor expression and PCA in APL cells may be down regulated by ATRA and As 2O 3 By down regulating TF expression, As 2O 3 might also be used to improve the DIC related hemorrhage in APL Our data indicate that elevated TF antigen in PML RARa+ U937 may be related to the fusion protein PML RARa The down regulating effect of ATRA and As 2O 3 on TF expression in U937 cells might not involve this fusion | 郭为民 王鸿利 赵维莅 诸江 璩斌 王学峰 | 2001 | Chinese Medical Journal2001，，1： | 2 |
| 16 | On Translating Similes and Metaphors in Traditional Chinese Medicine Literature显示文摘This research is to explore the approaches to translating similes and metaphors in TCM works into English based on the translation principles and methods suggested by foreign translators.Through the analysis,conclusions are drawn:①The principle of making sense should be emphasized,since TCM works mainly concentrate on conveying the objective information about human’s physical conditions during diagnosis and therapy.②Literal translation approach can be applied in translating similes to describe the symptoms and signs of the patients.③The translation of metaphors is more complicated.They can be converted into the form of similes or with certain explanations to achieve the comprehensibility of the target language.And some images can be left out from the metaphors or necessary explanations added to make them comprehensible to English readers. | China Petroleum China Guangzhou Training Center Qiu Hualing Guangzhou Chinese Medical University He Yi | 2007 | 语言与文化研究2007，，1： | 2 |
| 17 | A Study on Translation of Tourism Literature-from the Perspective of Skopos Theory显示文摘Tourism literature is a window for foreigners to know China and a medium for publicizing Chinese culture.Increasing the quality of translation of tourism literature is of great significance in promoting Chinese tourisms' further development.This paper explores the strategies to deal with the translation of tourism literature,taking Skopos Theory as the theoretical base. | 王雯 | 2012 | 海外英语2012，，12X： | 1 |
| 18 | THE DIFFERENTIATION INDUCING EFFECT OF TANSHINONE AND RETINOIC ACID ON HUMAN CERVICAL CARCINOMA CELL LINE(ME180) IN VITRO显示文摘THEDIFFERENTIATIONINDUCINGEFFECTOFTANSHINONEANDRETINOICACIDONHUMANCERVICALCARCINOMACELLLINE(ME180)INVITROYuanShulan袁淑兰,HuangG... | 袁淑兰 黄光琦 王修杰 周宏远 黄韧敏 宋毅 | 1996 | Chinese Journal of Cancer Research1996，8，4： | 1 |
| 19 | 城市新区交通发展战略特征分析——以柳州汽车城为例显示文摘随着城市化进程加快,许多城市进行了综合交通规划的编制或者修编。城市交通发展战略规划是综合交通规划首先进行的一步关键规划,它是支撑城市合理有序发展的前提,也是支撑路网有效运行的保证。本文通过总结国内外不同城市的交通发展战略,针对柳州汽车城特点,提出了多种交通发展战略,并基于Trans CAD软件,对不同的交通发展战略特征进行了分析和测试,最后确定了柳州汽车城应采取的交通发展战略模式。 | 刘家军 张建华 | 2014 | 交通运输工程与信息学报2014，12，4： | 1 |
| 20 | Hemostatic abnormalities associated with acute promyelocytic leukemia and corrective effects of all-trans-retinoic acid or arsenic trioxide treatment显示文摘Objective To study in vivo effect of all trans retinoic acid (ATRA) or arsenic trioxide (As 2O 3) on the expression of tissue factor (TF) and the hemostatic disorders, a series of parameters were measured in bone marrow blasts and plasma from acute promyelocytic leukemia (APL) patients Methods The plasma variables were measured by ELISA or chromogenic study The TF transcription was assessed using reverse transcription polymerase chain reaction technique (RT PCR) Results The blast cell procoagulant activity (PCA), TF antigen of APL cell lysates, as well as the transcription of APL TF mRNA elevated at diagnosis, were reduced after ATRA or As 2O 3 therapy The plasma level of platelet α granular membrane protein 140, soluble fibrinomonomer complex, thrombomo^dulin, tissue plasminogen activator and D dimer significantly increased, fibrinogen, antigen level of protein C, plasminogen, α2 plasminogen inhibitor and plasminogen activator inhibitor decreased at diagnosis, were restored to normal after complete remission but protein C activity and protein S remained elevated in ATRA group Conclusions There existed activation of platelets and consumption of anticoagulants as well as activation of coagulation and fibrinolytic system before treatment Both ATRA and As 2O 3 therapy down regulated the expression of TF mRNA, decreased the PCA and TF level in APL cells, inhibited coagulation activation, secondary hyperfibrinolysis and recorrected other hemostatic abnormalities, thus greatly improved the bleeding symptom in early stage of the | 赵维莅 王学锋 郭为民 璩斌 王鸿利 沈志祥 陈竺 王振义 | 2000 | Chinese Medical Journal2000，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员