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| 1 | 老年听力损失现状和干预策略显示文摘 | David JIANG 邹凌 | 2006 | 中国听力语言康复科学杂志2006，，1： | 17 |
| 2 | Effect of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors显示文摘OBJECTIVE:To evaluate the effects of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors,and to explore an efficient and noninvasive method for postoperative recovery of bowel functions.METHODS:Forty patients were randomly and evenly assigned into a regular nursing care group(RNC) and an acupoint electric stimulation group(AES).Patients in the RNC group received regular nursing care and patients in the AES group received regular nursing care plus electric stimulation of acupoints.The serum levels of gastrin(GAS),motilin(MOT),and cholecystokinin(CCK),and an electrogastrogram(EGG) of all the patients were evaluated on the first,third,and fifth day after surgery.The time to first flatus after surgery and the number of patients with side effects such as abdominal pain,abdominal distention,and diarrhea were recorded.RESULTS:There were significant differences between the two groups in GAS,MOT,EGG,time to first flatus,abdominal pain,abdominal distention,and diarrhea(P < 0.05).CONCLUSION:Electric stimulation on acupoints could increase levels of GAS and MOT,promote the recovery of gastrointestinal functions,and decrease complications among postoperative senile patients with gastrointestinal tumors. | Hou Lili Xu Lei Shi Yan Gu Fen | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 15 |
| 3 | Association between delayed cardioprotection of aged rat myocytes and activation of mitogenactivated protein kinase显示文摘Objective To study the cardioprotective effects of hypoxic preconditioning (HPC) on aged rat ventricular myocytes and the cellular mechanism of protection Methods In the model of hypoxia/reoxygenation (H/R) of isolated ventricular myocytes of aged rat, the effects of HPC on aged rat ventricular myocytes against lethal H/R stimulated ischemia/reperfusion (I/R) injury 24 hours later and the changes of mitogen activated protein kinase (MAPK) system were observed in the present study Results HPC attenuated the lactate dehydrogenase (LDH) release and ATP depletion in myocytes and increased the viability of myocytes It was also found that MAPK and its down stream kinase—S6 kinase were also activated after HPC Conclusion There is delayed cardioprotection in cardiac myocytes of aged rat and the cellular mechanism underlying might involve the activation of MAPK | 刘秀华 王士雯 武旭东 唐朝枢 | 2000 | Chinese Medical Journal2000，，1： | 14 |
| 4 | 关于中风病治疗的难点与突破口的思考 | 刘茂才 | 1997 | 中国中西医结合杂志1997，17，8： | 13 |
| 5 | Cataract surgery in aged patients:phacoemul-sification or small-incision extracapsular cataract surgery显示文摘AIM:To evaluate the effects and safety of phacoemu-lsification(Phaco) or small-incision extracapsular cataract surgery(SICS) and intraocular lens(IOL) implantation for aged patients.METHODS:Totally 137 aged patients(149 eyes) underwent cataract operation in the case of stable systemic condition,the blood pressure less than 160/95mmHg,blood glucose less than 8mmol/L,and under the help of electrocardiogram surveillance by anesthesiologists during the operation.106 aged patients(114 eyes) underwent Phaco while 31 aged patients(35 eyes) underwent SICS.The postoperative visual acuity,corneal endothelial cell loss,surgery time and major complications were observed and analyzed retrospectively.RESULTS:The best-corrected visual acuity(BCVA) of ≥0.6 was achieved in 135 eyes(92.6%) at 1 month postoperatively(χ2=259.730,P<0.001).For aged patients,both Phaco and SICS could significantly improve visual acuity with no significant difference(χ2=4.535,P>0.05).Postoperative corneal endothelial cell loss was 18.6%,in PHACO group,the rate was 18.5%;in SICS group,the rate was 19.0%,the difference of which was no significant(χ2=0.102,P >0.05).The surgery time was different in two groups.No severe complications occurred.CONCLUSION:Both Phaco and SICS combined with IOL implantation for aged patients are effective and safe.Before surgery,detailed physical examination should be performed.When the systemic condition is stable,cataract surgery for aged patients is safe. | Tao Jiang, Shan-Yao Zhao | 2011 | International Journal of Ophthalmology(English edition)2011，4，5： | 9 |
| 6 | 深圳市35~44岁人群口腔健康行为抽样调查分析显示文摘目的:评估深圳市35~44岁人群口腔健康行为,为深圳市口腔卫生保健工作提供信息支持。方法采用多阶段随机抽样方法,抽取深圳市35~44岁常住居民共1230人,按照《第三次全国口腔健康流行病学问卷调查方案》设计口腔健康调查问卷,就行为生活方式、口腔卫生服务的使用及获取口腔保健知识的来源及途径等进行调查分析,回收有效问卷1224份。结果深圳市35~44岁人群中,91.7%每天刷牙,55.6%每天刷牙2次及2次以上;72.1%的人使用含氟牙膏刷牙,牙线使用率极低;近1年内口腔科就诊率15.9%,90%以上是因为急、慢性牙疼和其他口腔问题,进行定期口腔检查的人口比率极少。电视/广播仍为获取口腔卫生知识的最主要途径,而其它途径少。结论提高人群口腔预防保健意识、改变行为习惯,丰富口腔健康教育内容及形式仍然是深圳市今后口腔预防保健工作的重点。 | 张莉 阮世红 武剑 | 2015 | 中华口腔医学研究杂志(电子版)2015，9，3： | 9 |
| 7 | Anti-cancer activities of S-allylmercaptocysteine from aged garlic显示文摘While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract(AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine(SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management. | LV Yi SO Kwok-Fai WONG Nai-Kei XIAO Jia | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 7 |
| 8 | Elderly patients had more severe postoperative complications after pancreatic resection:A retrospective analysis of 727 patients显示文摘AIM To examine the impact of aging on the short-term outcomes following pancreatic resection(PR) in elderly patients.METHODS A retrospective cohort study using prospectively collected data was conducted at the China National Cancer Center. Consecutive patients who underwent PR from January 2004 to December 2015 were identifiedand included. ‘Elderly patient' was defined as ones age 65 and above. Comorbidities, clinicopathology, perioperative variables, and postoperative morbidity and mortality were compared between the elderly and young patients. Univariate and multivariate analyses were performed using the Cox proportional hazard model for severe postoperative complications(grades Ⅲb-Ⅴ).RESULTS A total of 454(63.4%) patients were < 65-yearsold and 273(36.6%) patients were ≥ 65-yearsold, respectively. Compared to patients < 65-yearsold, elderly patients had worse American Society of Anesthesiologists scores(P = 0.007) and more comorbidities(62.6% vs 32.4%, P < 0.001). Elderly patients had more severe postoperative complications(16.8% vs 9.0%, P = 0.002) and higher postoperative mortality rates(5.5% vs 0.9%, P < 0.001). In the multivariate Cox proportional hazards model for severe postoperative complications, age ≥ 65 years [hazard ratio(HR) = 1.63; 95% confidence interval(CI): 1.18-6.30], body mass index ≥ 24 kg/m^2(HR = 1.20, 95%CI: 1.07-5.89), pancreaticoduodenectomy(HR = 4.86, 95%CI: 1.20-8.31) and length of operation ≥ 241 min(HR = 2.97; 95%CI: 1.04-6.14) were significant(P = 0.010, P = 0.041, P = 0.017 and P = 0.012, respectively).CONCLUSION We found that aging is an independent risk factor for severe postoperative complications after PR. Our results might contribute to more informed decision-making for elderly patients. | Ying-Tai Chen Fu-Hai Ma Cheng-Feng Wang Dong-Bing Zhao Ya-Wei Zhang Yan-Tao Tian | 2018 | World Journal of Gastroenterology2018，24，7： | 6 |
| 9 | Fast-track surgery in elderly patients undergoing colorectal cancer radical resection显示文摘Purpose:To investigate the efficacy of applying fast-track surgery(FTS)to elderly patients undergoing radical resection of colorectal cancer.Methods:Elderly patients undergoing radical resection of colorectal cancer received FTS(n=31)or routine(n=31)nursing care.The time to first anal exhaust,oral feeding and leaving the bed,duration of postoperative hospital stay and the incidence of complications were compared between the two groups.Results:Patients receiving FTS nursing demonstrated significantly shorter times to exhaust,oral feeding and leaving the bed compared with those receiving routine nursing(all p<0.01).Furthermore,there were significantly fewer incidences of postoperative pulmonary and urinary tract infections and intestinal adhesion in patients receiving FTS nursing(all p<0.05).Conclusion:Application of FTS in elderly patients undergoing radical resection of colorectal cancer facilitates an early rehabilitation after surgery,but places higher demands on nursing care. | Hong-Yan Kong Ai-Ling Yang Cai-Ya Ying Zhen-Fang Kong Ling-Ling Yuan Shan-Shan Hu Shun Zhang | 2014 | International Journal of Nursing Sciences2014，1，4： | 6 |
| 10 | Primary prevention of cardiovascular disease in older adults in China显示文摘Over the past two decades, the percentage of Chinese who is 60 years or older has increased from 5.2% in 1995 to 10.5% in 2015. Approximately 16% of the population in China was 60 years old and above in 2015. Since 1990, cardiovascular disease(CVD) has been the leading cause of death in China. Cardiovascular medications of older adults are usually more complicated than younger age groups due to polypharmacy, the presence of comorbidities and more susceptible to treatmentrelated adverse outcomes. Therefore, effective primary prevention of CVD for older adults is important in sustaining the health of older adults and reducing the burden of the healthcare system. Proper management of CVD-related risk factors, such as hypertension, dyslipidemia, diabetes and obesity, can remarkably reduce risks of CVDs in older Chinese. These risk factors can be modified by managing blood pressure, glucose and lipids via lifestyle modifications or receiving medications. Smoking cessation, healthy diets, strict alcohol intake and moderate physical exercise are examples of recommended lifestyle changes for remarkably recovering health conditions of older adults who have hypertension, dyslipidemia, obesity, diabetes or complications. Treatment prescriptions of older adults, in general, are recommended to be individualized and to be initiated at a low dose. The future directions for better primary CVD prevention in older adults include establishing guidelines for primary prevention of CVD for different older adults and further research on better management strategies of CVD risks for elderly Chinese. | Jian Yong Dong Lin Xue-Rui Tan | 2017 | World Journal of Clinical Cases2017，5，9： | 5 |
| 11 | Clinical, sonographic characteristics and long-term prognosis of valvular heart disease in elderly patients显示文摘Background Valvular heart disease(VHD)is expected to become more prevail as the population ages and disproportionately affects older adults.However,direct comparison of clinical characteristics,sonographic diagnosis,and outcomes in VHD patients aged over 65 years is scarce.The objective of this study was to evaluate the differences in clinical characteristics and prognosis in two age-groups of geriatric patients with VHD.Methods We retrospectively enrolled consecutive individuals aged>65 years from Guangdong Provincial Peopled Hospital and screened for VHD using transthoracic echocardiography(TTE)or transesophageal echocardiography(TEE).Finally,260(48.9%)patients were in the 65-74 years group,and 272(51.1%)were in the>75-year group.Factors that affected long-term survival was explored.A multivariable Cox hazards regression was performed to identify the predictors of major adverse cardiac events(MACEs)in each group.Results In our population,the older group were more likely to have chronic obstructive pulmonary disease(COPD),degenerative VHD,but with less rheumatic VHD,aortic stenosis(AS)and mitral stenosis(MS).Compared with those aged 65-74 years,the older group had a higher incidence of all-cause death(10.0%vs.16.5%,P=0.027),ischemic stroke(13.5%vs.20.2%,P=0.038)and MACEs(37.3%vs.48.2%,P=0.011)at long-term follow-up.In multivariable Cox regression analysis,mitral regurgitation,a history of COPD,chronic kidney disease,diabetes,hypertension,atrial fibrillation and New York Heart Association(NYHA)functional class were identified as independent predictors of MACEs in the older group.Conclusion Advanced age profoundly affect prognosis and different predictors were associated with MACEs in geriatric patients with VHD. | Feier SONG Fang-Zhou LIU Yuan-Feng LIANG Gary Tse Xin LI Hong-Tao LIAO Ji-Yan CHEN | 2019 | Journal of Geriatric Cardiology2019，16，1： | 4 |
| 12 | Emergency laparotomy in octogenarians: A 5-year study of morbidity and mortality显示文摘AIM: To determine the morbidity and mortality associated with emergency laparotomy for a clinically acute abdomen in patients aged ≥ 80 years. METHODS: In this retrospective audit, octogenarians undergoing emergency laparotomy between 1st January 2005 and 1 st January 2010 were identified using the Galaxy Theatre System. Patients undergoing abdominal surgery through groin crease incisions or Lanz or Gridiron incisions were excluded. Also simple appendectomies were excluded. All patients were aged 80 years or more at the time of their surgery. Data were obtained using casenote review with a standardised proforma to determine patient age, American Society of Anesthesiologists (ASA) grade, indications for surgery, early (within 30 d) and late (after 30 d) complications, mortality and length of stay. Data were inserted into a Microsoft Excel spreadsheet and analysed. RESULTS: One hundred patients were identified from the database (Galaxy) as having undergone emergency laparotomy. Of those, 55 underwent the procedure for intestinal procedures and 37 for secondary peritonitis.There was a 2:1 female predominance; average age 85 and ASA grade 3. Bowel resection was required in 51 out of the 100 patients and 22 (43%) died. Other procedures included appendicectomy, adhesiolysis, repair of AAA graft leak and colostomies for the pathological process resulting in an acute abdomen. Twelve of 100 patients (12%) suffered intra-operative complications, including splenic and bowel-serosal tears. Seventy patients (70%) had postoperative complications including myocardial infarction, wound infection, haematoma and sepsis. Overall mortality was 45/100 patients (45%). The major causes of death were sepsis (19/45 patients, 42%), underlying cancer (13/45 patients, 29%); with others including bowel obstruction (2/45 patients, 4%), myocardial and intestinal ischaemia and dementia. CONCLUSION: Emergency laparotomy in octogenarians carries a significant morbidity and mortality. In particular, surgery requiring bowel resection has higher mortality than without resection. | Gemma Green Irshad Shaikh Roland Fernandes Henk Wegstapel | 2013 | World Journal of Gastrointestinal Surgery2013，5，7： | 4 |
| 13 | EB病毒抗体检测在鼻咽癌早诊应用中的评价显示文摘作者在广东鼻咽癌高发区四会市、广州市的54425名。年龄在30-59岁自然人群中,应用多项EB病毒(EBV)血清学指标结合鼻咽光导纤维镜、病理组织学检查等手段,进行前瞻性观察、验证及评价这些鼻咽癌“高危人群”血清学指标的应用价值。我们认为:在鼻咽癌高发区人群筛查中,应用EEV抗体检测,凡具下列指标之一者。为患鼻咽癌高危人群,应给予鼻咽光纤镜及病理检查,以期发现早期病人。①EBVIgA/VCA≥1:80或EDAb≥50%。②EBVIgA/VCA、IgA/EA、EDAb3项中任何两项阳性。③EBVIgA/VCA、IgA/EA、EDAb3项中任何单项持续高滴度或滴度持续上升。 | 黄腾波 车景廉 陈德林 凌启南 黄惠明 黄启洪 | 1995 | 中山大学学报(医学科学版)1995，15，S1： | 4 |
| 14 | Subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy for the treatment of slow transit constipation in an aged population:A retrospective control study显示文摘AIM To compare the efficacy,improved quality of life,and prognosis in patients undergoing either subtotal colonic bypass with antiperistaltic cecoproctostomy(SCBAC) or subtotal colonic bypass plus colostomy with antiperistaltic cecoproctostomy(SCBCAC) for the treatment of slow transit constipation.METHODS Between October 2010 and October 2014,aged patients with slow transit constipation who were hospitalized and underwent laparoscopic surgery in our institute weredivided into two groups: the bypass group,15 patients underwent SCBAC,and the bypass plus colostomy group,14 patients underwent SCBCAC. The following preoperative and postoperative clinical data were collected: gender,age,body mass index,operative time,first flatus time,length of hospital stay,bowel movements(BMs),Wexner fecal incontinence scale,Wexner constipation scale(WCS),gastrointestinal quality of life index(GIQLI),numerical rating scale for pain intensity(NRS),abdominal bloating score(ABS),and ClavienDindo classification of surgical complications(CD) before surgery and at 3,6,12,and 24 mo after surgery.RESULTS All patients successfully underwent laparoscopic surgery without open surgery conversion or surgeryrelated death. The operative time and blood loss were significantly less in the bypass group than in the bypass plus colostomy group(P = 0.007). No significant differences were observed in first flatus time,length of hospital stay,or complications with CD > 1 between the two groups. No patients had fecal incontinence after surgery. At 3,6,and 12 mo after surgery,the number of BMs was significantly less in the bypass plus colostomy group than in the bypass group. The parameters at 3,6,12,and 24 mo after surgery in both groups significantly improved compared with the preoperative conditions(P < 0.05),except NRS at 3,6 mo after surgery in both groups,ABS at 12,24 mo after surgery and NRS at 12,24 mo after surgery in the bypass group. WCS,GIQLI,NRS,and ABS significantly improved in the bypass plus colostomy group compared with the bypass group at 3,6,12,and 24 mo after surgery(P < 0.05) except WCS,NRS at 3,6 mo after surgery and ABS at 3 mo after surgery. At 1 year after surgery,a barium enema examination showed that the emptying time was significantly better in the bypass plus colostomy group than in the bypass group(P = 0.007).CONCLUSION Laparoscopic SCBCAC is an effective and safe procedure for the treatment of slow transit constipation in an aged population and can significantly improve the prognosis. Its clinical efficacy is more favorable compared with that of SCBAC. Laparoscopic SCBCAC is a better procedure for the treatment of slow transit constipation in an aged population. | Yang Yang Yong-Li Cao Wen-Hang Wang Yuan-Yao Zhang Nan Zhao Dong Wei | 2018 | World Journal of Gastroenterology2018，24，23： | 4 |
| 15 | PREDICTION OF LOCATION OF HIDDEN ORE DEPOSITS IN THE AGED ORE FIELDS: AN EXAMPLE FROM FENGHUANGSHAN ORE FIELD, TONGLING, CHINA显示文摘This paper discusses the strategy for successfully predicting the location of potential hidden ore bodies in aged ore field, and presents the result of location prediction of hidden ore bodies in Fenghuangshan ore field, Tongling. Innovative conceptual targeting procedures based on a genetic understanding of mineralization systems, carefully geological investigation and correct deduction, together with new geochemical and geophysical technology and integrating of comprehensive information are all very important for the successful prediction. In the aged Fenghuangshan ore field, through researching by application of the metallogenic theory of polygenetic compound ore deposits and triple frequency induced polarization method and exploration tectono geochemical method, we predicted location and quality of hidden ore bodies. According to the prediction, hidden high quality Cu Au ore bodies of skarn type and porphyry type have been discovered. | LIU Liang ming, PENG Sheng lin, YIANG Qun zhou, SHAO Yong jun and WANG Zhi qiang (Institute of Diwa Theory and Metallogeny, Central South University, Changsha 410083, China) | 2001 | Geotectonica et Metallogenia2001，25，1： | 3 |
| 16 | Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats显示文摘The α5 subunit-containing gamma-amino butyric acid type A receptors(α5 GABAARs) are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in hippocampal neurons. These tonic currents can be enhanced by low-dose isoflurane, which is associated with learning and memory impairment. Inverse agonists of α5 GABAARs, such as L-655,708, are able to reverse the short-term memory deficit caused by low-dose isoflurane in young animals. However, whether these negative allosteric modulators have the same effects on aged rats remains unclear. In the present study, we mainly investigated the effects of L-655,708 on low-dose(1.3%) isoflurane-induced learning and memory impairment in elderly rats. Young(3-month-old) and aged(24-month-old) Wistar rats were randomly assigned to receive L-655,708 0.5 hour before or 23.5 hours after 1.3% isoflurane anesthesia.The Morris Water Maze tests demonstrated that L-655,708 injected before or after anesthesia could reverse the memory deficit in young rats. But in aged rats, application of L-655,708 only before anesthesia showed similar effects. Reverse transcription-polymerase chain reaction showed that low-dose isoflurane decreased the mRNA expression of α5 GABAARs in aging hippocampal neurons but increased that in young animals. These findings indicate that L-655,708 prevented but could not reverse 1.3% isoflurane-induced spatial learning and memory impairment in aged Wistar rats. All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Academy of Military Medical Science of China(approval No. NBCDSER-IACUC-2015128) in December 2015. | Zi-Fang Zhao Lei Du Teng Gao Lin Bao Yuan Luo Yi-Qing Yin Yong-An Wang | 2019 | Neural Regeneration Research2019，14，6： | 3 |
| 17 | Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study显示文摘BACKGROUND The incidence of inflammatory bowel disease(IBD)is increasing in Asia.Numerous risk factors associated with IBD development have been investigated.AIM To investigate trends and environmental risk factors of Crohn’s disease(CD)diagnosed in persons aged≥40 years in South Korea.METHODS Using the National Health Insurance Service database,a total of 14060821 persons aged>40 years who underwent national health screening in 2009 were followed up until December 2017.Patients with newly diagnosed CD were enrolled and compared with non-CD cohort.CD was identified according to the International Classification of Diseases 10th revision and the rare/intractable disease registration program codes from the National Health Insurance Service database.The mean follow-up periods was 7.39 years.Age,sex,diabetes,hypertension,smoking,alcohol consumption,regular exercise,body mass index,anemia,chronic kidney disease(CKD)and dyslipidemia were adjusted for in the multivariate analysis model.RESULTS During the follow-up,1337(1.33/100000)patients developed CD.Men in the middle-aged group(40-64 years)had a higher risk than women[adjusted hazard ratio(aHR)1.46,95%confidence interval(CI):1.29-1.66];however,this difference tended to disappear as the age of onset increases.In the middle-aged group,patients with a history of smoking[(aHR 1.46,95%CI:1.19-1.79)and anemia(aHR 1.85,95%CI:1.55-2.20)]had a significantly higher CD risk.In the elderly group(age,≥65 years),ex-smoking and anemia also increased the CD risk(aHR 1.68,95%CI:1.22-2.30)and 1.84(95%CI:1.47-2.30,respectively).Especially in the middle-aged group,those with CKD had a statistically elevated CD risk(aHR 1.37,95%CI:1.05-1.79).Alcohol consumption and higher body mass index showed negative association trend with CD incidence in both of the age groups.[Middle-aged:aHR 0.77(95%CI:0.66-0.89)and aHR 0.73(95% CI:0.63-0.84),respectively][Elderly-group:aHR 0.57(95% CI:0.42-0.78)and aHR 0.84(95%CI 0.67-1.04),respectively].For regular physical activity and dyslipidemia,negative correlation between CD incidences was proved only in the middle-aged group[aHR 0.88(95%CI:0.77-0.89)and aHR 0.81(95%CI:0.68-0.96),respectively].CONCLUSION History of cigarette smoking,anemia,underweight and CKD are possible risk factors for CD in Asians aged>40 years. | Jung Min Moon Eun Ae Kang Kyungdo Han Seung Wook Hong Hosim Soh Seona Park Jooyoung Lee Hyun Jung Lee Jong Pil Im Joo Sung Kim | 2020 | World Journal of Gastroenterology2020，26，4： | 2 |
| 18 | Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over显示文摘AIM To increase the number of available grafts.METHODS This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old(control group).RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus(HCV)-positivity [hazard ratio(HR) = 2.35; 95% confidence interval(CI): 1.55-3.56; P = 0.00]; recipient age(HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease(D-MELD)(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium(HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD(donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients(77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). CONCLUSION A DR-MELD ≥ 75000 must be avoided in order to obtain the best results in LT with donors ≥ 70 years old. | Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero Alvaro García-Sesma Marina Pérez-Flecha Carlos Munoz- Arce Carmelo Loinaz-Segurola Alejandro Manrique-Municio | 2018 | World Journal of Gastroenterology2018，24，47： | 2 |
| 19 | 老年患者腹腔镜胆囊切除术并发症的预防显示文摘目的 总结老年患者腹腔镜胆囊切除术及并发症预防的经验.方法 回顾性分析126例老年腹腔镜胆囊切除术的临床资料,其中急性胆囊炎22例,慢性胆囊炎104例.结果 腹腔镜胆囊切除术成功率90.5%,中转开腹手术12例(9.5%),术后并发症11例(8.7%).结论 老年患者腹腔镜胆囊切除术须加强围手术期的处理,才能更好地预防并发症. | 陈国锋 祁付珍 顾殿华 张建淮 王业波 蔡勇 许刚 | 2009 | 临床外科杂志2009，17，12： | 1 |
| 20 | Factors Influencing Preventive Behaviors of Mothers for Diarrhea in Children Aged 1-5 Years in Buol District, Indonesia显示文摘This study aims to determine the factors related with mothers' behaviors in preventing diarrhea in children aged 1-5 years inBuol District. This was a cross-sectional survey design with health belief model as the conceptual framework. A total of 300mothers were selected by using purposive sampling method based on criteria. Mothers were interviewed by using astructured questionnaire during October to November 2015. A chi-square (X^2) test was used to determine a significantassociation between independent variables and dependent variable. The finding showed that 68.3% of mothers hadgood behaviors in preventing diarrhea. The factors significantly related to mothers' behaviors included perceivedsusceptibility to diarrhea, perceived severity of diarrhea, perceived benefits of diarrhea prevention behaviors, and perceivedbarriers of diarrhea prevention behaviors CP 〈 .01, p 〈 .01, p 〈 .01, and p 〈 .01 respectively). Further, mothers had highperception to comply with diarrhea prevention behaviors. Those who perceived that diarrhea prevention behaviors werehighly beneficial to their children had good behaviors in preventing diarrhea. However, taking certain actions must considernegative aspects. | Helmi Rumbo Susheewa Wichaikull Boosaba Sanguanprasit | 2016 | Journal of Sociology Study2016，6，12： | 1 |
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