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| 1 | 努力改进我国颅脑创伤急救体系及监测技术显示文摘 | 张赛 只达石 | 2005 | 中华神经外科杂志2005，21，4： | 56 |
| 2 | 创伤性颅脑损伤的康复治疗进展显示文摘创伤性颅脑损伤(traumatic brain injury,TBI)的发病率每年约180/—250/10万[1]。最新数据表明,美国每年约有23.5万人因非致命性TBI住院治疗,其中43.3%的患者在接受康复治疗1年后遗留有不同程度残疾[2]。我国目前尚缺乏大规模的TBI流行病学调查。大多数TBI尤其是重型TBI需要长期的综合性康复治疗,家庭和社会为此负担较大。 | 徐慧英 李爱萍 | 2011 | 中国康复医学杂志2011，26，5： | 59 |
| 3 | 中国帕金森病脑深部电刺激疗法专家共识显示文摘脑深部电刺激(deep brain stimulation,DBS)疗法已经成为治疗中晚期帕金森病(Parkinson’s disease,PD)的有效方法。此疗法1998年在我国首次使用,至今已十余年,DBS疗法明显地改善了PD患者的运动症状,提高了生活质量。随着我国老龄人口的增加,需要接受DBS疗法的患者将进一步增加。为了更好地规范我国DBS疗法的适应证和流程,以及进一步加强神经内、外科之间的密切配合与合作,特制定此专家共识。 | 无 陈生弟 高国栋 | 2012 | 中华神经科杂志2012，45，7： | 46 |
| 4 | Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation显示文摘Electroacupuncture has been widely used to treat cognitive impairment after cerebral ischemia,but the underlying mechanism has not yet been fully elucidated.Studies have shown that autophagy plays an important role in the formation and development of cognitive impairment,and the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway plays an important role in autophagy regulation.To investigate the role played by the PI3K/Akt signaling pathway in the electroacupuncture treatment of cerebral ischemia/reperfusion rat models,we first established a rat model of cerebral ischemia/reperfusion through the occlusion of the middle cerebral artery using the suture method.Starting at 2 hours after modeling,electroacupuncture was delivered at the Shenting(GV24)and Baihui(GV20)acupoints,with a dilatational wave(1-20 Hz frequency,2 mA intensity,6 V peak voltage),for 30 minutes/day over 8 consecutive days.Our results showed that electroacupuncture reduced the infarct volume in a rat model of cerebral ischemia/reperfusion injury,increased the mRNA expression levels of the PI3K/Akt signaling pathwayrelated factors Beclin-1,mammalian target of rapamycin(mTOR),and PI3K,increased the protein expression levels of phosphorylated Akt,Beclin-1,PI3K,and mTOR in the ischemic cerebral cortex,and simultaneously reduced p53 mRNA and protein expression levels.In the Morris water maze test,the latency to find the hidden platform was significantly shortened among rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture stimulation.In the spatial probe test,the number of times that a rat crossed the target quadrant was increased in rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture stimulation.Electroacupuncture stimulation applied to the Shenting(GV24)and Baihui(GV20)acupoints activated the PI3K/Akt signaling pathway and improved rat learning and memory impairment.This study was approved by the Animal Ethics Committee of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,China(approval No.8150150901)on March 10,2016. | Hui-Ling Wang Fei-Lai Liu Rui-Qing Li Ming-Yue Wan Jie-Ying Li Jing Shi Ming-Li Wu Jun-Hua Chen Wei-Juan Sun Hong-Xia Feng Wei Zhao Jin Huang Ren-Chao Liu Wen-Xue Hao Xiao-Dong Feng | 2021 | Neural Regeneration Research2021，16，6： | 48 |
| 5 | 老年非心脏手术患者术后谵妄危险因素分析显示文摘 | 刘金虎 岳云 | 2009 | 临床麻醉学杂志2009，25，2： | 40 |
| 6 | 脑外伤康复的现状与未来发展趋势显示文摘1脑外伤康复现状1.1脑外伤康复需求巨大脑外伤(traumatic brain injury)是指由于受到钝击伤、穿透伤或加/减速力而引起的颅脑创伤,并进而引起相应的症状如意识水平或神智清醒程度降低、记忆缺失或遗忘、其他神经病学或神经心理学异常、甚至死亡等。美国每年新增脑外伤患者5万人死亡,23万人住院治疗,8万人遗留长期残疾。 | 励建安 | 2011 | 中国康复医学杂志2011，26，12： | 36 |
| 7 | 重症颅脑损伤后意识障碍的精准康复显示文摘1颅脑损伤 颅脑损伤(traumatic brain injury,TBI)是外界暴力直接或间接作用于头部所造成的损伤,是世界上年轻人致死致残的首要因素,尤其在发展中国家,由于交通事故增多,TBI的发生率呈现逐年上升的趋势。 | 吴毅 | 2017 | 中国康复医学杂志2017，32，3： | 37 |
| 8 | Early Enteral Combined with Parenteral Nutrition Treatment for Severe Traumatic Brain Injury:Effects on Immune Function,Nutritional Status and Outcomes显示文摘Objective To compare the conjoint effect of enteral nutrition (EN) and parenteral nutrition (PN)with single EN or PN on immune function, nutritional status, complications and clinical outcomes of patientswith severe traumatic brain injury (STBI).Methods A prospective randomized control trial was carried out from January 2009 to May 2012 inNeurological Intensive Care Unit (NICU). Patients of STBI who met the enrolment criteria (Glasgow ComaScale score 6~8; Nutritional Risk Screening ≥3) were randomly divided into 3 groups and were administratedEN, PN or EN+PN treatments respectively. The indexes of nutritional status, immune function,complications and clinical outcomes were examined and compared statistically. | Ming-chao Fan Qiao-ling Wang Wei Fang Yun-xia Jiang Lian-di Li Peng Sun Zhi-hong Wang | 2016 | Chinese Medical Sciences Journal2016，31，4： | 37 |
| 9 | Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury显示文摘Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled receptor,and it may be neuroprotective against cerebral ischemia injury.However,the precise mechanisms of the effects of apelin-13 remain to be elucidated.To investigate the effects of apelin-13 on apoptosis and autophagy in models of cerebral ischemia/reperfusion injury,a rat model was established by middle cerebral artery occlusion.Apelin-13(50μg/kg)was injected into the right ventricle as a treatment.In addition,an SH-SY5Y cell model was established by oxygen-glucose deprivation/reperfusion,with cells first cultured in sugar-free medium with 95%N2 and 5%CO2 for 4 hours and then cultured in a normal environment with sugar-containing medium for 5 hours.This SH-SY5Y cell model was treated with 10-7 M apelin-13 for 5 hours.Results showed that apelin-13 protected against cerebral ischemia/reperfusion injury.Apelin-13 treatment alleviated neuronal apoptosis by increasing the ratio of Bcl-2/Bax and significantly decreasing cleaved caspase-3 expression.In addition,apelin-13 significantly inhibited excessive autophagy by regulating the expression of LC3B,p62,and Beclin1.Furthermore,the expression of Bcl-2 and the phosphatidylinositol-3-kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR)pathway was markedly increased.Both LY294002(20μM)and rapamycin(500 nM),which are inhibitors of the PI3K/Akt/mTOR pathway,significantly attenuated the inhibition of autophagy and apoptosis caused by apelin-13.In conclusion,the findings of the present study suggest that Bcl-2 upregulation and mTOR signaling pathway activation lead to the inhibition of apoptosis and excessive autophagy.These effects are involved in apelin-13-induced neuroprotection against cerebral ischemia/reperfusion injury,both in vivo and in vitro.The study was approved by the Animal Ethical and Welfare Committee of Jining Medical University,China(approval No.2018-JS-001)in February 2018. | Zi-Qi Shao Shan-Shan Dou Jun-Ge Zhu Hui-Qing Wang Chun-Mei Wang Bao-Hua Cheng Bo Bai | 2021 | Neural Regeneration Research2021，16，6： | 35 |
| 10 | New development thoughts on the bio-inspired intelligence based control for unmanned combat aerial vehicle显示文摘Bio-inspired intelligence is in the spotlight in the field of international artificial intelligence,and unmanned combat aerial vehicle(UCAV),owing to its potential to perform dangerous,repetitive tasks in remote and hazardous,is very promising for the technological leadership of the nation and essential for improving the security of society.On the basis of introduction of bioinspired intelligence and UCAV,a series of new development thoughts on UCAV control are proposed,including artificial brain based high-level autonomous control for UCAV,swarm intelligence based cooperative control for multiple UCAVs,hy-brid swarm intelligence and Bayesian network based situation assessment under complicated combating environments, bio-inspired hardware based high-level autonomous control for UCAV,and meta-heuristic intelligence based heterogeneous cooperative control for multiple UCAVs and unmanned combat ground vehicles(UCGVs).The exact realization of the proposed new development thoughts can enhance the effectiveness of combat,while provide a series of novel breakthroughs for the intelligence,integration and advancement of future UCAV systems. | DUAN HaiBin 1 ,SHAO Shan 2 ,SU BingWei 3 &ZHANG Lei 41 State Key Laboratory of Science and Technology on Holistic Flight Control,School of Automation Science and Electrical Engineering, Beijing University of Aeronautics and Astronautics,Beijing 100191,China 2 Flight Control Department,Shenyang Aircraft Design and Research Institute,Shenyang 110035,China 3 Beijing Institute of Near Space Vehicle’s System Engineering,Beijing 100076,China 4Integration and Project Section,Air Force Equipment Academy,Beijing 100085,China | 2010 | Science China(Technological Sciences)2010，53，8： | 32 |
| 11 | Susceptibility weighted imaging: Clinical applications and future directions显示文摘Susceptibility weighted imaging(SWI) is a recently developed magnetic resonance imaging(MRI) technique that is increasingly being used to narrow the differential diagnosis of many neurologic disorders. It exploits the magnetic susceptibility differences of various compounds including deoxygenated blood, blood products, iron and calcium, thus enabling a new source of contrast in MR. In this review, we illustrate its basic clinical applications in neuroimaging. SWI is based on a fully velocity-compensated, high-resolution, three dimensional gradientecho sequence using magnitude and phase images either separately or in combination with each other, in order to characterize brain tissue. SWI is particularly useful in the setting of trauma and acute neurologic presentations suggestive of stroke, but can also characterize occult low-flow vascular malformations, cerebral microbleeds, intracranial calcifications, neurodegenerative diseases and brain tumors. Furthermore, advanced MRI post-processing technique with quantitative susceptibility mapping, enables detailed anatomical differentiation based on quantification of brain iron from SWI raw data. | Ahmet Mesrur Halefoglu David Mark Yousem | 2018 | World Journal of Radiology2018，10，4： | 32 |
| 12 | 原发性颅内淋巴瘤分型及治疗显示文摘 原发性脑淋巴瘤(primary lymphoma of the brain,PLB)是一种较罕见的中枢神经系统恶性肿瘤,约占颅内原发性肿瘤0.3%~1.5%,占全身淋巴瘤1%以下,不向中枢神经系统轴以外播散,生物学行为具有侵袭性,病理形态存在异质性. | 李明洙 罗力 高乃康 富春雨 窦长武 王涛 李云霞 | 2006 | 中华神经外科杂志2006，22，4： | 30 |
| 13 | 脑钠肽对急性冠状动脉综合征临床病情及预后的判断显示文摘研究显示,脑钠肽(B-type/brain natriuretic peptide,BNP)在急性冠状动脉综合征(ACS)患者预后评估中呈现出重要的作用。本研究旨在评价我院收治ACS患者血BNP浓度的变化及其对临床病情和预后的评价。 | 孙同文 王乐信 张彦周 刘新灿 朱明军 邱春光 黄振文 | 2006 | 中华心血管病杂志2006，34，7： | 29 |
| 14 | Pancreatic encephalopathy in 24 patients with severe acute pancreatitis显示文摘BACKGROUND: Pancreatic encephalopathy (PE), an un- familiar complication of severe acute pancreatitis ( SAP) , is difficult to diagnose and treat, and it has a high mortality. The aim of this study was to investigate the manifestation, classification, mechanism and therapy of PE. METHODS: Of 132 patients with SAP treated at our hospi- tal from March 1994 to March 2004, 24 patients complicated by PE were analyzed retrospectively. RESULTS: The causes of SAP were mostly biliary and alco- holic. Twenty-four patients (18.2%) were complicated by PE within 3 hours-38 days ( average 6. 6 days) [ 21 (87. 5%) within 2 weeks, and 3(12.5%) after 2 weeks]. Eleven pa- tients were male and 13 female, with an average of 47 years (range 25-72 years). Excitement or restrain was the main manifestation. Nine patients (37.5%) received surgery and 15 (62.5%) conservative treatment, with a mortality of 11.1 % (1/9) and 66.7% (10/15), respectively. CONCLUSIONS: PE occurs 2 weeks after SAP and is part of multiple organ failure (MOF). Some patients have PE in the late stage of SAP because of lack of VitB1 and nutri- tion. But PE can be prevented by prescribing adequate nu- trition and VitB1 in the early stage of SAP. | Xiong Ding, Chang-An Liu, Jian-Ping Gong and Sheng-Wei Li Chongqing, China Department of Hepatobiliary Surgery, Second Clinical College, Chongqing University of Medical Sciences, Chongqing 400010, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 26 |
| 15 | 颅内肿瘤周围水肿药物治疗专家共识(第1版)显示文摘一、前言
肿瘤周围水肿(peritumoral brain edema,PTBE)多见于胶质瘤、脑膜瘤和转移瘤,是神经外科常见的临床问题,直接影响肿瘤的诊断、治疗及预后。本文旨在加深神经外科医生对神经系统PTBE的认识,明确对FFBE诊断和治疗的基本原则,提供切实可行的规范化的药物治疗建议。 | | 2010 | 中华医学杂志2010，90，1： | 26 |
| 16 | 难治性心力衰竭的内科治疗进展显示文摘难治性心力衰竭( refractory heart failure , RHF)是终末期心血管病常见的并发症,由于病理生理机制复杂,单一药物治疗难度极大。目前,通过传统药物的联合治疗,米力农、重组人脑利钠肽( recombinant human brain natriuretic peptide , rh-BNP)和左西孟旦等新型药物的临床运用,血液净化、主动脉球囊反搏、心室辅助装置和体外模肺氧合等脏器支持的实施,RHF救治成功率得到提高。本文就近年来RHF内科治疗进展进行综述。 | 陈怿(综述) 童华生 江东新 苏磊(审校) | 2014 | 中国急救医学2014，34，8： | 26 |
| 17 | Progress and perspectives on targeting nanoparticles for brain drug delivery显示文摘Due to the ability of the blood–brain barrier(BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem. In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood–brain tumor barrier(BBTB), and nose-to-brain barrier. Delivery strategies are focused on overcoming the BBB, directly targeting diseased cells in the brain, and dual-targeted delivery. The major concerns and perspectives on constructing brain-targeted delivery systems are discussed. | Huile Gao | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 26 |
| 18 | 创伤性脑损伤后垂体前叶功能减退及临床意义显示文摘创伤性颅脑损伤(traumatic brain injure,TBI)后出现神经内分泌功能紊乱并不少见,TBI与神经内分泌的关系日益受到关注,垂体前叶功能减退可以显著影响颅脑损伤患者功能及健康的恢复。但其临床表现隐匿,并有可能被TBI后出现的一系列症状所掩盖,TBI后垂体前叶功能减退可能会被误诊、漏诊。TBI后垂体前叶功能减退可能加重TBI症状甚至导致潜在的致命性内分泌危机。 | 胡峰 张赛 | 2007 | 中华神经外科杂志2007，23，11： | 24 |
| 19 | 人脑源性神经营养因子基因修饰神经干细胞移植对痴呆大鼠学习记忆的改善显示文摘目的 观察神经干细胞( neural stem cell,NSC)和人脑源性神经营养因子( human brain derivedneurotrophic factor,h BDNF)基因修饰NSC移植对阿尔茨海默病( Alzheimer disease,AD)模型鼠的学习记忆改善作用。 方法 SD大鼠4 0只随机分为4组,每组10只。 组为正常对照组;其余3组进行单侧切断大鼠穹窿海马伞( fibria-fornix,FF)制备AD模型, 组为损伤组; 、组于术后10~12 d,侧脑室移植h BDNF基因修饰及未修饰的NSC分别为NSC组和BDNF组。移植后2周进行Morris水迷宫定位航行及空间探索行为学检测。 结果 组和 组的平均逃避潜伏期为4 1.84±2 1.76 s和2 5 .2 3±17.0 6 s,较 组潜伏期70 .91±2 3.6 7s明显缩短,差异有统计学意义( P<0 .0 1) ;平台象限游泳距离占总游泳距离的百分比: 组和 组分别为36 .9%和4 2 .0 % ,较 组2 6 .0 %明显增高,差异有统计学意义( P<0 .0 1) ; 组大鼠采取边缘式和随机式搜索模式显著多于其它各组,差异有统计学意义( P<0 .0 1)。其中 组大鼠的平均逃避潜伏期和平台象限游泳距离百分比及搜索策略接近 组( P>0 .0 5 ) ,采取直线式和趋向式的搜索策略显著多于其它各组( P<0 .0 1)。 结论 NSC和h BDNF基因修饰NSC移植对AD模型鼠的行为学有不同程度的改善,h BDNF基因修饰NSC移植较? | 赵志英 胡海涛 冯改丰 许杰华 张海英 | 2005 | 中国修复重建外科杂志2005，19，5： | 23 |
| 20 | 插管型喉罩的临床应用及进展显示文摘喉罩通气道(1aryngealmaskairway,LMA)作为一种声门上通气装置,自1983年英国Brain医师发明后,因其操作简便、成功率高、损伤小、对循环影响轻微等优点而广泛应用于临床。近年来,LMA在困难气道处理中的临床应用价值也越来越被人们所认可,不仅用于急症气道处理, | 郅娟 杨冬 邓晓明 | 2014 | 临床麻醉学杂志2014，30，2： | 22 |
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