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| 1 | 响应面法在试验设计与优化中的应用显示文摘简要介绍了响应面法,并结合实例介绍了响应面法所用数据处理软件Design Expert在试验设计与优化中的应用. | 张泽志 韩春亮 李成未 | 2011 | 河南教育学院学报(自然科学版)2011，20，4： | 156 |
| 2 | 基于TRIZ理论和功能分析的产品创新设计显示文摘阐述了产品功能分析法、TRIZ理论的最终理想解和物场分析方法,建立了基于TRIZ理论和功能分析的产品创新设计流程。该流程将产品的创新设计分为产品功能分析、抽象理想解,构建系统物场模型和解决问题功能模型几个阶段,指导设计人员从产品的功能出发,快速实现产品的创新设计。并以液压缸往复密封为例,说明该流程的有效性。 | 卢希美 张付英 张青青 | 2010 | 机械设计与制造2010，，12： | 67 |
| 3 | 回归乡土的课程设计:乡村教育重建的课程策略显示文摘乡村教育重建的课程目标乃是在一般性地促进乡村青少年发展的基础上,面对当下乡村少年生存的现实,引导他们更多地认识脚下的土地,建立个人与乡土的和谐联系,培育他们的文化自信,从整体上促进乡村少年健全人格的养成。乡村教育课程设计的基本原则主要表现为普遍性知识与乡土知识之间的平等性、差异性和开放性。乡村教育课程设计的基本路径包括:乡土课程资源的开发、乡土教材的开发、乡土文化阅读资源的开发以及整个课程体系中乡土价值的凸显。乡村教育课程设计的根本指向乃是乡村生活方式的重建。新乡村教育课程开发、新乡村理念的培植、新乡村生活理想的开启,成为当下乡村教育重建的基本课程理念。 | 刘铁芳 | 2010 | 现代大学教育2010，26，6： | 63 |
| 4 | 复杂嵌入式实时系统体系结构设计与分析语言:AADL显示文摘首先归纳了AADL(architecture analysis and design language)的发展历程及其主要建模元素.其次,从模型驱动设计与实现的角度综述了AADL在不同阶段的研究与应用,总结了研究热点,分析了现有研究的不足,并对AADL的建模与分析工具、应用实践进行了概述.最后,探讨了AADL的发展与研究方向. | 杨志斌 皮磊 胡凯 顾宗华 马殿富 | 2010 | 软件学报2010，21，5： | 75 |
| 5 | 采用Design-Expert设计进行优化Falcon分选试验显示文摘采用Design-Expert6.0软件对Falcon离心重力分选脱硫试验进行了方案设计和试验结果分析;讨论了脱硫试验效果的评价方法,给出了综合脱硫效率与试验影响因素之间的定量关系模型,给出了综合脱硫效率的残差分布以及不同操作变量之间的综合脱硫效率等值线和三维关系;利用Design-Expert6.0对Falcon分选试验条件进行了优化,获得了最佳综合脱硫效率的操作指标. | 陶有俊 Daniel Tao 赵跃民 刘炯天 王卓雅 | 2005 | 中国矿业大学学报2005，34，3： | 48 |
| 6 | Optimization of the head shape of the CRH3 high speed train显示文摘Aiming at optimizing the head shape of the CRH3 high speed train, an efficient optimization approach is proposed. The CFD analysis by solving Navier-Stokes equations is coupled with optimization calculation based on the multi-objective genetic algorithm, meanwhile the arbitrary shape deformation technique (ASD) is also introduced into the design flow, which greatly shortens the time consumption for geometry regeneration and flow field remeshing. As a result, the efficiency of the optimization calculation is highly improved. Statistical analysis is done to the designs in the design space, and the correlation between the design variables and the objective is studied to find out the key variables that most affect the objective. Response surface analysis is also performed to get the nonlinear relationship between the key design variables and the objective with the Kriging algorithm. Finally, after the optimization, an aerodynamic performance comparison between the optimal shape and the original shape reveals that the original shape of CRH3 high speed train owns a very stable aerodynamic performance and can be trustingly used in industry. | SUN ZhenXu1, SONG JingJing1 & AN YiRan1 College of Engineering, State Key Laboratory for Turbulence and Complex Systems, Peking University, Beijing 100871, China | 2010 | Science China(Technological Sciences)2010，53，12： | 35 |
| 7 | Plackett-Burman和Box-Benhnken Design实验设计法优化华根霉产糖化酶发酵培养基的研究显示文摘应用Plackett-Burman设计法对影响华根霉发酵的培养基组分进行筛选,所选取的11个相关因素为:葡萄糖、麦芽糖、蔗糖、橄榄油、蛋白胨、黄豆粉、酪蛋白胨、麦麸、MgSO4·7H2O、K2HPO4、KH2PO4。确定影响产糖化酶活的关键因素为橄榄油、酪蛋白胨、麦麸,接着进行最陡爬坡实验逼近3个关键因素的最大响应区域。在此基础上,采用Box-BenhnkenDesign实验设计法对发酵培养基组分进行优化,得出最佳条件。此时橄榄油为0.01%、酪蛋白胨为8.14%、麦麸为4.32%、糖化酶活为18.7U,比优化前提高81%。 | 汪彬彬 车振明 | 2011 | 食品科技2011，36，5： | 39 |
| 8 | Androgen receptor: structure, role in prostate cancer and drug discovery显示文摘Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade by drugs that prevent the production of androgens and/or block the action of the AR inhibits prostate cancer growth. However, resistance to these drugs often occurs after 2-3 years as the patients develop castration-resistant prostate cancer (CRPC). In CRPC, a functional AR remains a key regulator. Early studies focused on the functional domains of the AR and its crucial role in the pathology. The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer. An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided herein. | MH Eileen TAN Jun LI H Eric XU Karsten MELCHER Eu-leong YONG | 2015 | Acta Pharmacologica Sinica2015，36，1： | 39 |
| 9 | A Review on Lower Limb Rehabilitation Exoskeleton Robots显示文摘Lower limb rehabilitation exoskeleton robots integrate sensing, control, and other technologies and exhibit the characteristics of bionics, robotics, information and control science, medicine, and other interdisciplinary areas. In this review, the typical products and prototypes of lower limb exoskeleton rehabilitation robots are introduced and stateof-the-art techniques are analyzed and summarized. Because the goal of rehabilitation training is to recover patients’ sporting ability to the normal level, studying the human gait is the foundation of lower limb exoskeleton rehabilitation robot research. Therefore, this review critically evaluates research progress in human gait analysis and systematically summarizes developments in the mechanical design and control of lower limb rehabilitation exoskeleton robots. From the performance of typical prototypes, it can be deduced that these robots can be connected to human limbs as wearable forms;further, it is possible to control robot movement at each joint to simulate normal gait and drive the patient’s limb to realize robot-assisted rehabilitation training. Therefore human–robot integration is one of the most important research directions, and in this context, rigid-flexible-soft hybrid structure design, customized personalized gait generation, and multimodal information fusion are three key technologies. | Di Shi Wuxiang Zhang Wei Zhang Xilun Ding | 2019 | Chinese Journal of Mechanical Engineering2019，32，4： | 36 |
| 10 | Design of rock support system under rockburst condition显示文摘As mining and civil tunneling progresses to depth, excavation-induced seismicity and rockburst problems increase and cannot be prevented. As an important line of defense, ground control measures and burst-resistant rock support are used to prevent or minimize damage to excavations and thus to enhance workplace safety. Rock support in burst-prone ground differs from conventional rock support where controlling gravity-induced rockfalls and managing shallow zones of loose rock are the main target. Rock support in burst-prone ground needs to resist dynamic loads and large rock dilation due to violent rock failure. After reviewing the rockburst phenomenon, types of rockbursts, damage mechanisms, and rockburst support design principles and acceptability criteria, this paper describes that the support selection process in burst-prone ground is iterative, requiring design verification and modification based on field observations. An interactive design tool for conducting rockburst support design in underground tunnels is introduced to facilitate cost-effective design. | Peter K. Kaiser | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，3： | 32 |
| 11 | 基于数字化逆向建模的3D打印实验教学显示文摘提出了先进制造技术领域的逆向工程与新兴3D打印技术相结合的实验课程,给出了实施方案。实验内容包括了用手持式激光扫描仪对物体表面进行扫描,获取点云数据,然后将点云数据导入数字化逆向建模软件Geomagic Design Direct中进行处理,完成物体CAD实体模型重建,最后将模型导入CubeX 3D打印机中进行打印,实现快速制造。该实验内容体现了先进制造技术领域的最新发展趋势,在现代工业中有广泛的应用前景;实验教学的实施顺应了产业界对人才培养的最新需求,对于促进学生在现代产品设计与制造技术等方面的应用和创新能力具有积极的作用。 | 成思源 周小东 杨雪荣 张湘伟 郭钟宁 | 2015 | 实验技术与管理2015，32，1： | 34 |
| 12 | Design Principles of the Non-smooth Surface of Bionic Plow Moldboard显示文摘The diverse non-smooth body surfaces to reduce soil adhesion are the evolutional results for the soil animals to fit the adhesive and wet environment and can be used as a biological basis for the design of bionic plow moldboard. The model surfaces for bionic simulation should be taken from soil animal digging organs, on which the soil motion is similar to what is on the surface of moldboard. By analyzing the distribution of non-smooth units on the body surface of the ground beetle jaw and the soil moving stresses, the design principles of the bionic moldboard for the local and the whole moldboard were presented respectively. As well, the effect of soil moving speed on reducing adhesion, the dimensions relationship between soil particles and non-smooth convexes, the relationship between the enveloping surface of non-smooth convexes and the initial smooth surface of the plow body, and the convex types of the sphere coronal and the pangolin scales,etc.were discussed. | Luquan Ren, Shiqiao Deng, Jingchun Wang, Zhiwu Han Key Laboratory of Terrain-Machine Bionics Engineering (Ministry of Education,China), Jilin University at Nanling Campus, Changchun 130022,P.R. China | 2004 | Journal of Bionic Engineering2004，1，1： | 28 |
| 13 | AutoCAD Civil 3D和3ds Max Design在道路建模中的应用显示文摘介绍利用AutoCAD Civil 3D进行道路建模的过程,并将Civil 3D道路模型导入到3ds Max Design中作进一步加工,从而进一步获取道路的三维景观模型。 | 李俊超 李楼 | 2013 | 测绘通报2013，，2： | 26 |
| 14 | 基于ZigBee无线传感器网络的农业环境监测系统研究与设计显示文摘针对目前农业环境在线监测的需要,提出了一种基于ZigBee无线传感器网络的农业环境监测系统设计方案,该监测系统由无线监测网络和远程监控中心组成,可对影响作物生长的温度、湿度、光照等环境变量进行实时监测。介绍了系统的总体架构,设计开发了无线传感器网络节点、基站以及软件流程。由于采用了无线传输方式,该系统解决了有线通信方式存在的难以扩展、难以升级等问题,具有低功耗、低成本、扩展灵活等优点,其应用前景非常广阔。 | 蔡镔 毕庆生 李福超 王栋 杨英 袁超 | 2010 | 江西农业学报2010，22，11： | 24 |
| 15 | 响应面法优化海洋细菌MP-2酯酶发酵条件显示文摘采用响应面法(Response surface methodology)对海洋细菌MP-2酯酶的发酵条件进行了优化.首先采用了Plackett-Burman方法对影响酯酶发酵的因素进行评价,筛选出了3个显著因素为豆饼粉、花生粕和种龄,并利用DesignExpert7.0.3软件完成RSM法对显著性因素的进一步优化从而确定最佳条件.当花生粕0·9%;豆饼粉2·29%;接种量5·98%时,此时预测的最大酯酶活力为334·46U/mL.在最佳发酵条件下,优化后该酯酶活力由258·8U/mL提高到318·2U/mL.实际酶活力达到理论预测值的95%,十分接近. | 平芮巾 孙谧 刘均忠 王跃军 郝建华 张胜军 | 2008 | 应用与环境生物学报2008，14，4： | 24 |
| 16 | Molecular biology and the diagnosis and treatment of liver diseases显示文摘MolecularbiologyandthediagnosisandtreatmentofliverdiseasesHowardJ.Worman,FengLin,NaotoMamiyaandPaulJ.MustacchiaSubjectheading... | Howard J. Worman, Feng Lin, Naoto Mamiya and Paul J. Mustacchia | 1998 | World Journal of Gastroenterology1998，4，3： | 24 |
| 17 | Lanthanide NIR luminescence for telecommunications, bioanalyses and solar energy conversion显示文摘Present-day advanced technologies heavily rely on the exciting magnetic and spectroscopic properties of lanthanide ions. In particular, their ability to generate well-characterized and intense near-infrared (NIR) luminescence is exploited in any modern fiber-optic telecommunication network. In this feature article, we first summarize the whereabouts underlying the design of highly luminescent NIR molecular edifices and materials. We then focus on describing the main trends in three applications related to this spectral range: telecommunications, biosciences, and solar energy conversion. In telecommunications, efforts concentrate presently on getting easily processable polymer-based waveguide amplifiers. Upconversion nanophosphors emitting in the visible after NIR excitation are now ubiquitous in many bioanalyses while their application to bio-imaging is still in its early stages; however, highly sensitive NIR-NIR systems start to be at hand for both in vitro and in vivo imaging, as well as dual probes combining magnetic resonance and optical imaging. Finally, both silicon-based and dye-sensitized solar cells benefit from the downconversion and upconversion capabilities of lanthanide ions to harvest UV and NIR solar light and to boost the overall quantum efficiency of these next-generation devices. | Jean-Claude G. Bünzli Svetlana V. Eliseeva | 2010 | Journal of Rare Earths2010，28，6： | 22 |
| 18 | 油菜秸杆外壳对水溶液中六价铬的吸附作用显示文摘为探讨油菜秸秆外壳去除水溶液中重金属铬的可能性及其影响因素,并研究其吸附性能和吸附机制.采用Box-Behnken Design实验设计研究了水溶液中六价铬[Cr(Ⅵ)]初始浓度、p H值范围、油菜秸秆外壳添加量和吸附温度4个因素对油菜秸秆外壳去除溶液中Cr(Ⅵ)的影响作用;用吸附等温方程、吸附动力学方程与热力学方程分别探讨了油菜秸秆外壳去除水溶液中Cr(Ⅵ)的行为;采用红外光谱技术对油菜秸秆外壳吸附水溶液Cr(Ⅵ)前后进行表征,探讨其吸附机制.油菜秸秆外壳去除溶液中Cr(Ⅵ)的最佳条件组合为:在吸附时间为1440min时,Cr(Ⅵ)初始浓度为99.15mg/L、p H值为1.01、油菜秸秆外壳添加量为2.90g/L和吸附温度35.70℃,Cr(Ⅵ)去除率为91.97%;吸附等温线拟合,吸附Cr(Ⅵ)行为符合Freundlich方程,为优惠吸附;热力学研究表明:溶液中Cr(Ⅵ)吸附属吸热反应,且为自发吸附行为;吸附动力学显示:油菜秸秆外壳去除溶液Cr(Ⅵ)符合准二阶动力学方程,吸附过程中存在离子交换;红外光谱提示:吸附过程中,O—H、C—H、NH3+、N—H和C—O基团与Cr(Ⅵ)络合吸附发挥了重要作用.油菜秸秆外壳能够有效吸附水溶液中的Cr(Ⅵ),p H值是最为重要的影响因素. | 刘新 冷言冰 谷仕艳 张遵真 | 2015 | 中国环境科学2015，35，6： | 22 |
| 19 | Box-Behnken Design效应面法在制剂处方优化中的应用显示文摘Box-Behnken Design(BBD)效应面法是一种实验条件寻优的方法 ,采用多元二次回归方程拟合各因素与响应值之间的函数关系,找出预测的响应最优值以及相应的实验条件,是种多因素非线性实验优化方法,可以评估因素的非线性影响,在处方优化中广泛使用。该设计方法试验次数少,应用方便,优选的条件预测性好。目前,微球、自乳化释药体系、脂质体等制剂的处方优化越来越多选择BBD的优化法。 | 张南生 孙卫军 郭虹 应聪慧 | 2015 | 中国医药导报2015，12，23： | 22 |
| 20 | 基于Geomagic Design X的正逆向混合建模显示文摘逆向工程中关于正逆向混合建模的研究在近几年来成为热点。介绍了逆向工程中常用混合建模方法与特点,提出了基于自动特征识别与面片草图的混合建模方法,根据设计意图重新定义设计参数,以Geomagic Design X软件为平台进行实体重构。通过实例获得了可编辑的、基于历史树的CAD数据模型,同时验证了该混合建模的准确性和便捷性。 | 冯超超 成思源 杨雪荣 骆少明 | 2017 | 机床与液压2017，45，17： | 22 |
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