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| 1 | α_1肾上腺素能受体激动剂围术期应用专家共识(2017版)显示文摘α1肾上腺素能受体(α1-AR)激动剂(以下简称α1激动剂)是临床常用的血管活性药物之一,但在围术期的应用缺乏规范。近年来,随着围术期容量治疗研究的深入,围术期容量管理由开放性或限制性补液策略转变为目标导向液体治疗(goal-directed fluid therapy,GDFT)策略。 | 俞卫锋 王天龙 郭向阳 陈雷 徐铭军 徐世元 赵晓琴 赵丽云 徐懋 张伟 宁巧明 宋锴澄 张鸿飞 | 2017 | 临床麻醉学杂志2017，33，2： | 62 |
| 2 | 河南省栾川县三道庄钼钨矿床地质和流体包裹体研究显示文摘河南省栾川县三道庄钼钨矿床是东秦岭钼矿带的5个超大型钼矿床之一,产于华北克拉通南缘,形成于燕山期碰撞造山体制的后碰撞构造环境。矿体定位于燕山期花岗斑岩与栾川群浅变质碎屑岩-碳酸盐建造的外接触带,矿石构造主要是浸染状和网脉状,广泛发育长英质脉、辉钼矿脉、石英-辉钼矿脉、石英-黄铁矿脉、碳酸盐-萤石脉等。围岩蚀变类型复杂,主要有矽卡岩化、钾化、硅化、绿帘石化、绿泥石化、绢云母化、碳酸盐化、萤石化以及黄铁矿化、辉钼矿化等硫化物化,矿石类型主要是矽卡岩型和角岩型,属于典型矽卡岩型钼钨矿床。成矿过程分为矽卡岩阶段(早)、石英-硫化物阶段(中)和石英-碳酸盐(晚)3个阶段。流体包裹体有CO_2-H_2O、H_2O-NaCl和含子晶包裹体等3种类型,早阶段主要发育CO_2-H_2O和含子晶包裹体,晚阶段只见H_2O-NaCl包裹体,中阶段发育3类包裹体;早、中、晚3个阶段流体包裹体均一温度分别为394~552℃、290~410℃和140~290℃,盐度分别为20.60 wt%~67.18 wt%NaCl.eqv、6.30 wt%~48.55 wt%NaCl.eqv和3.39 wt%~11.46wt%NaCl.eqv。早阶段流体具有高温、高盐度、富含CO_2的岩浆热液特征,晚阶段流体以低温、低盐度、贫CO_2为特征,中阶段流体沸腾作用强烈,是成矿物质快速沉淀的重要机制。成矿系统由静岩压力向静水压力体系转变,趋于开放。 | 石英霞 李诺 杨艳 | 2009 | 岩石学报2009，25，10： | 42 |
| 3 | Two series of copper-gold deposits in the middle and lower reaches of the Yangtze River area (MLYRA) and the hydrogen, oxygen, sulfur and lead isotopes of their ore-forming hydrothermal systems显示文摘Based on studies on the geological characteristics of the copper-gold deposits in the middle and lower reaches of the Yangtze River area (MLYRA) and their hydrogen, oxygen, sulfur and lead isotope compositions, it is concluded that there existed two series of copper-gold deposits. They are evolutional products of two ore-forming hydrothermal systems in different geodynamic settings and geological era. Series I is stratiform or stratabound copper-gold deposits. These deposits were formed by submarine exhalation and sedimentation of hydrothermal solutions in Her-cynian tensional tectonic environment after bot brine ascending along contemporaneous faults and exhaled into the sea-floor. Series II consists of copper-gold deposits related to medium and acidic magmatic intrusions. Their mineralizations took place in Yanshanian in a tensional or a transitional period to the tensional tectonic environment from the composite of the tethys tectonic regime and the Paleo-Pacific ocean tectonic regime, as well as | 周涛发 袁峰 岳书仓 赵勇 | 2000 | Science China Earth Sciences2000，43，S1： | 40 |
| 4 | 双层桨搅拌槽内层流流场与混合时间的数值模拟显示文摘采用Laminar模型、多重参考系法(Multiple reference frame,MRF)和示踪剂浓度法对双层六直叶桨搅拌槽内高黏非牛顿流体层流流场和混合时间进行数值模拟,分析其流动特性、示踪剂扩散过程、示踪剂浓度响应曲线和混合时间;采用示踪粒子法和酸碱指示剂变色法对透明有机玻璃搅拌槽内流动场和混合过程进行试验测定。结果表明,双层桨中间面将示踪剂先控制在加料的半层内随主体介质流动扩散,当浓度差增大后再向另外半层扩散;在搅拌剧烈的桨叶区或在中间面加入示踪剂,可获得更短的混合时间;不同位置混合完成的时间不同,根据搅拌要求合理选择监测点,可避免资源浪费或搅拌不充分;提高搅拌转速,可使搅拌槽内介质混合过程加快,混合时间减小;试验结果验证了数值模拟结果的准确性,为非牛顿流体层流搅拌槽的设计和工程应用提供了理论依据。 | 梁瑛娜 高殿荣 拜亮 | 2015 | 机械工程学报2015，51，16： | 34 |
| 5 | 内蒙古克什克腾旗小东沟斑岩型钼矿床成岩成矿机制探讨显示文摘本文选取内蒙古克什克腾旗的小东沟斑岩型钼矿区作为研究区,它位于西拉沐伦钼矿带的西南部。对小东沟岩体进行了主微量元素、SHRIMP锆石U-Pb定年等地球化学方面的研究;对岩体中的钾长石和含矿矿物辉钼矿进行了普通铅同位素分析。小东沟岩体具有高硅富钾、REE含量低、Zr含量高、无负铕异常、高ε_(Nd)(t)、低Sr_i等特点,指示岩浆起源于加厚新生下地壳的熔融,同时具有高温、快速熔融、快速析离逃离源区的特点;小东沟岩体的SHRIMP锆石U-Pb定年结果为142±2Ma,对应140Ma左右主应力场由南北向转为东西向的构造体制大转折时期,这个时期大兴安岭处于伸展的构造环境下,底侵作用发育,地幔物质可以添加到下地壳熔融形成的岩浆中;对岩体钾长石和辉钼矿进行的普通铅同位素分析显示前者具有从造山带-地幔过渡的特征,后者则显示有地幔特征,说明成岩、成矿物质来自两个不同的源区,下地壳的岩浆和地幔含矿流体发生了混合。通过以上的分析,结合水-岩浆物理反应的实验结果,本文提出小东沟斑岩型钼矿床的成矿模式:大兴安岭地区在早白垩世伸展的构造背景下,地幔含矿流体加入受底侵作用加热的下地壳中使之熔融形成岩浆,随后更多的地幔含矿流体进入岩浆房,促使其迅速析离逃逸出源区,二者一起上升侵位。在岩浆温度较高时,地幔含矿流体和岩浆大致以较稳定的液态不混溶的状态共存;当岩浆和流体侵位到较浅深度时,压力下降,温度降低,晶体增多,流体-岩浆体系变得不稳定,岩浆被流体分割成许多很小的岩浆团。流体中H^+、K^+和各种成矿元素的存在使之必然会和岩浆或冷却后形成的岩石发生蚀变反应,并晶出成矿矿物,形成现在我们看到的具有浸染状矿化现象的小东沟斑岩型钼矿床。 | 覃锋 刘建明 曾庆栋 罗照华 | 2009 | 岩石学报2009，25，12： | 29 |
| 6 | Review of zero-net-mass-flux jet and its application in separation flow control显示文摘Since the zero-net-mass-flux (ZNMF) jet was first used as a laboratory flow control method in 1990's, it has attracted much attention. The ZNMF jet has unique features such as compact actuator, no requirement for external air supply, complex piping, etc., and becomes a hot topic research subject in fluid mechanics. This review introduces the state of the art in the development of ZNMF jet in the quiescent fluid, the interaction of the ZNMF jet with the cross flow and its application in the separation flow control. The evolution of the vortex ring/pair and the spacial flow structure of the ZNMF in quicent fluid or cross flow are presented, as well as the key parameter effects. At last, the applications of ZNMF jet in the wake control of the circular cylinder, the separation control on the airfoil and the aerodynamic force or moment control on MAV/UAV are presented. | ZHANG PanFeng WANG JinJun FENG LiHao | 2008 | Science China(Technological Sciences)2008，51，9： | 30 |
| 7 | 湖泊水动力模型外部输入条件不确定性和敏感性分析显示文摘以我国典型的大型浅水湖泊太湖为研究区域,采用国内外常用的环境流体动力学模型(EFDC),结合拉丁超立方取样(LHS)方法,研究湖泊水动力模型中4个重要的外部输入条件,即3个边界输入条件(出入湖流量、风速、风向)和1个初始输入条件(初始水位),对模型水动力模拟结果(水位、水龄以及流场)的影响与贡献.结果表明,初始水位的设定对模拟全湖水位和水龄产生决定性影响,不确定性的贡献率分别达到85.73%.和1166.125%,对垂向平均流速影响的贡献率只有3%;风速对表面流速模拟结果影响较大,贡献率达到58.70%,而对水位和水龄的贡献率分别为5.25%和3.00%.在垂向上,各层流速受外部输入条件不确定性的影响规律相似,贡献率排序为风速(55%-60%)〉风向(10%-15%)〉初始水位≈出入湖流量(1%~5%).因此在模拟大型浅水湖泊水动力过程时,可以根据不同的输出目标能够有针对性地提高外部输入条件的准确度,为提高模型精确度提供有效信息. | 李一平 邱利 唐春燕 布旻晟 田威 余钟波 Kumud Acharya | 2014 | 中国环境科学2014，34，2： | 30 |
| 8 | Origin of ore-forming fluids of the Dachang Sn-polymetallic ore deposit: Evidence from helium isotopes显示文摘The ore genesis model for the Dachang Sn-polymetallic ore deposit has long been in dispute, and the major debate focuses on whether the stratiform and massive orebodies formed during the Yanshanian magmatic-hydro-thermal event or they were products of Devonian syn-sedi-mentary exhalative-hydrothermal event. This note presents new helium isotope data from fluid inclusions of four pyrites and one fluorite. The pyrites were collected from the stratiform and massive orebodies in the deposit, and their 3He/4He ratios are significantly higher than 1, ranging from 1.7 to 2.5 Ra, which indicates a mantle component in the responsible hydrothermal fluids. It is suggested that the ore-forming fluids were a mixture of deep circulating seawater and a mantle-derived fluid, which are similar to many of those modern submarine hydrothermal fluids. In contrast, the fluorite, collected from a granite-related hydrothermal vein in the deposit, shows a low 3He/4He ratio of 0.7 Ra, which indicates no mantle component | Kuidong Zhao Shaoyong Jiang Hongquan Xiao Pei Ni | 2002 | Chinese Science Bulletin2002，47，12： | 28 |
| 9 | Experimental study on dehydration melting of natural biotite-plagioclase gneiss from High Himalayas and implications for Himalayan crust anatexis显示文摘Here we present the results of dehydration melting, melt morphology and fluid migration based on the dehydration melting experiments on natural bio-tite-plagioclase gneiss performed at the pressure of 1.0-1.4 GPa, and at the temperature of 770-1028℃. Experimental results demonstrate that: (i) most of melt tends to be distributed along mineral boundaries forming 'melt film' even the amount of melt is less than 5 vol%; melt connectivity is controlled not only by melt topology but also by melt fraction; (ii) dehydration melting involves a series of subprocesses including subsoiidus dehydration reaction, fluid migration, vapor-present melting and vapor-absent melting; (iii) experiments produce peraluminous granitic melt whose composition is similar to that of High Himalayan leucogranites (HHLG) and the residual phase assemblage is Pl+Qz+ Gat+Bio+Opx±Cpx+IIm/Rut±Kfs and can be comparable with granulites observed in Himalayas. The experiments provide the evidence that biotite-plagioclase gneiss is one of | YANG Xiaosong JIN Zhenmin Ernst Huenges Frank R.Schilling Bernd Wunder | 2001 | Chinese Science Bulletin2001，46，10： | 27 |
| 10 | Hydrothermal ore deposits in collisional orogens显示文摘Hydrothermal ore deposits at convergent plate boundaries represent extraordinary metal enrichment in the continental crust. They are generally associated with felsic magmatism in extensional settings at high thermal gradients. Although their formation is common during accretionary orogeny, more and more ore deposits have been discovered recently in the collisional orogens of China. Because collisional orogeny was operated in a compressional regime at low thermal gradients, it is not favorable for mobilization of ore-forming elements and thus for the production of hydrothermal ore deposits. Nevertheless, continental collision is generally preceded by oceanic subduction, which enables the preliminary enrichment of ore-forming elements in the mantle wedge due to chemical metasomatism by subducting slab-derived fluids. This gave rise to metal pre-enriched domains in the overriding lithosphere, which may be reactivated by extensional tectonism for hydrothermal mineralization either immediately during accretionary orogeny or at a later time during and after collisional orogeny. It is these tectonic processes that have resulted in the progressive enrichment of ore-forming elements through the geochemical differentiation of the subducting oceanic crust, the metasomatic mantle domains and the mafic juvenile crust, respectively, at different depths. Finally, the reactivation of metal pre-enriched domains by continental rifting in the orogenic lithosphere is the key to the metallogenesis of collisional orogens. | Yongfei Zheng Jingwen Mao Yanjing Chen Weidong Sun Pei Ni Xiaoyong Yang | 2019 | Science Bulletin2019，64，3： | 26 |
| 11 | 肺泡上皮细胞功能特性与内毒素性急性肺损伤显示文摘 | 张秋金 李银平 黎檀实 | 2005 | 中国危重病急救医学2005，17，6： | 24 |
| 12 | 目标导向液体治疗临床新进展显示文摘自Shoemaker等[1]于1988年首先提出围术期理想循环状态的概念,2001年早期目标导向治疗组[2]提出外科输液应满足的几个目标,围术期的液体治疗似乎有了一个明确的方向,相继涌现出许多以目标导向液体治疗(goal-directed fluid therapy,GPFT)为理念的基础和临床研究。所谓GPFT,指根据患者的性别、 | 解雅英 于建设 吴莉 | 2012 | 中华临床医师杂志(电子版)2012，6，7： | 24 |
| 13 | 基于CFD的船用柴油机缸体水套设计显示文摘利用数值模拟对6170型船用柴油机的冷却水套进行了冷却性能研究,优化设计了缸体冷却水套。对原机缸体冷却水套内冷却水的流场分布、冷却水套内壁面换热系数、各缸冷却均匀性和压力损失进行了分析。计算结果表明:原机缸体水套上部存在冷却强度不足、冷却均匀性差的缺陷,不能满足缸套冷却要求。通过计算提出了提高缸体上部冷却强度及改善冷却均匀性的优化设计方案,从而满足了气缸套的冷却需要,确保了发动机工作的可靠性。 | 张强 王志明 | 2005 | 内燃机学报2005，23，6： | 23 |
| 14 | Helium and argon isotopic geochemistry of Jinding superlarge Pb-Zn deposit显示文摘The study results of He and Ar isotopes from fluid inclusions in pyrites formed during mineralization stage of Jinding superlarge Pb-Zn deposit in west Yunnan, China are reported. The data show that the 40Ar/ 36Ar and 3He/ 4He ratios of fluid inclusions are respectively in the range of 301.7\385.7 and 0.03\0.06Ra, suggesting the ore-forming fluid is a kind of air saturated meteoric groundwater. On the basis of research on coupled relationships among He, Ar, S and Pb isotopes, the evolution history of ore-forming fluid of the deposit can be summarized as (i) air saturated meteogenic groundwater infiltrated down and was heated→ (ii) leached S, C and radiogenic He, Ar from the basinal strata → (iii) leached Pb and Zn from mantle-derived igneous rocks located in the bottom of the basin→ (iv) ore-forming fluid ascended and formed the deposit. Due to this process, the isotope signatures of crustal radiogenic He, atmospheric Ar (with partial radiogenic 40Ar), crustal S and mantle-derived Pb remained in the ore-forming fluid. | 胡瑞忠 G.Turner P.G.Burnard 钟宏 叶造军 毕献武 | 1998 | Science China Earth Sciences1998，41，4： | 22 |
| 15 | 栾川上房沟钼矿床流体包裹体特征及其地质意义显示文摘上房沟钼矿床位于栾川断裂带北侧的华北克拉通南缘,矿体赋存于晚元古代栾川群碎屑岩-碳酸盐建造中。钼成矿经历了早、中、晚3个阶段:早阶段为钾长石-石英-辉钼矿-黄铁矿组合,中阶段为石英-辉钼矿-多金属硫化物组合,晚阶段以方解石-石英-萤石脉为特征。流体包裹体可划分为富/含CO_2型、含子矿物型和NaCl-H_2O型3类。早、中成矿阶段发育较多CO_2-H_2O型和含子晶型包裹体,晚阶段为NaCl-H_2O型包裹体。早阶段流体具有高温(320℃~500℃)、高盐度(31.75~66.75wt%NaCl eqv.)、富CO_2的特点,显示浆控高温热液矿床的特征;中阶段流体具有中温(190℃~400℃)、中等盐度(2.07~12.85 wt%NaCl eqv.,个别超过30 wt%NaCl eqv.)、富/含CO_2特点;晚阶段为中低温(160℃~260℃)、低盐度(~4.8 wt%NaCl eqv.)、贫CO_2的NaCl-H_2O体系。早、中阶段流体沸腾作用强烈,造成CO_2不断逸失、流体氧化性降低、成矿物质大量沉淀,是成矿的重要机制。 | 杨艳 张静 杨永飞 石英霞 | 2009 | 岩石学报2009，25，10： | 20 |
| 16 | Early phase of acute pancreatitis: Assessment and management显示文摘Acute pancreatitis(AP) is a potentially life-threatening disease with a wide spectrum of severity. The overall mortality of AP is approximately 5%. According to the revised Atlanta classification system, AP can be classified as mild, moderate, or severe. Severe AP often takes a clinical course with two phases, an early and a late phase, which should both be considered separately. In this review article, we first discuss general aspects of AP, including incidence, pathophysiology, etiology, and grading of severity, then focus on the assessment of patients with suspected AP, including diagnosis and risk stratification, followed by the management of AP during the early phase, with special emphasis on fluid therapy, pain management, nutrition, and antibiotic prophylaxis. | Veit Phillip Jrg M Steiner Hana Algül | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 19 |
| 17 | PLANE SURFACE SUDDENLY SET IN MOTION IN A VISCOELASTIC FLUID WITH FRACTIONAL MAXWELL MODEL显示文摘The fractional calculus approach in the constitutive relationshipmodel of viscoelastic fluid is introduced.The flow near a wall suddenly set in mo-tion is studied for a non-Newtonian viscoelastic fluid with the fractional Maxwellmodel.Exact solutions of velocity and stress are obtained by using the discrete in-verse Laplace transform of the sequential fractional derivatives.It is found that theeffect of the fractional orders in the constitutive relationship on the flow field is signif-icant.The results show that for small times there are appreciable viscoelastic effectson the shear stress at the plate,for large times the viscoelastic effects become weak. | 谭文长 徐明瑜 | 2002 | Acta Mechanica Sinica2002，18，4： | 19 |
| 18 | Smoothed particle hydrodynamics(SPH) for modeling fluid-structure interactions显示文摘Fluid-structure interaction(FSI) is a class of mechanics-related problems with mutual dependence between the fluid and structure parts and it is observable nearly everywhere, in natural phenomena to many engineering systems. The primary challenges in developing numerical models with conventional grid-based methods are the inherent nonlinearity and timedependent nature of FSI, together with possible large deformations and moving interfaces. Smoothed particle hydrodynamics(SPH) method is a truly Lagrangian and meshfree particle method that conveniently treats large deformations and naturally captures rapidly moving interfaces and free surfaces. Since its invention, the SPH method has been widely applied to study different problems in engineering and sciences, including FSI problems. This article presents a review of the recent developments in SPH based modeling techniques for solving FSI-related problems. The basic concepts of SPH along with conventional and higher order particle approximation schemes are first introduced. Then, the implementation of FSI in a pure SPH framework and the hybrid approaches of SPH with other grid-based or particle-based methods are discussed. The SPH models of FSI problems with rigid, elastic and flexible structures, with granular materials, and with extremely intensive loadings are demonstrated. Some discussions on several key techniques in SPH including the balance of accuracy, stability and efficiency, the treatment of material interface, the coupling of SPH with other methods, and the particle regularization and adaptive particle resolution are provided as concluding marks. | Moubin Liu Zhilang Zhang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，8： | 19 |
| 19 | MicroRNAs as diagnostic and therapeutic tools for Alzheimer's disease: advances and limitations显示文摘Alzheimer's disease(AD) is the most common age-related, progressive neurodegenerative disease. It is characterized by memory loss and cognitive decline and responsible for most cases of dementia in the elderly. Late-onset or sporadic AD accounts for > 95% of cases, with age at onset > 65 years. Currently there are no drugs or other therapeutic agents available to prevent or delay the progression of AD. The cellular and molecular changes occurring in the brains of individuals with AD include accumulation of β-amyloid peptide and hyperphosphorylated tau protein, decrease of acetylcholine neurotransmitter, inflammation, and oxidative stress. Aggregation of β-amyloid peptide in extracellular plaques and the hyperphosphorylated tau protein in intracellular neurofibrillary tangles are characteristic of AD. A major challenge is identifying molecular biomarkers of the early-stage AD in patients as most studies have been performed with blood or brain tissue samples(postmortem) at late-stage AD. Subjects with mild cognitive impairment almost always have the neuropathologic features of AD with about 50% of mild cognitive impairment patients progressing to AD. They could provide important information about AD pathomechanism and potentially also highlight minimally or noninvasive, easy-to-access biomarkers. MicroRNAs are dysregulated in AD, and may facilitate the early detection of the disease and potentially the continual monitoring of disease progression and allow therapeutic interventions to be evaluated. Four recent reviews have been published of microRNAs in AD, each of which identified areas of weakness or limitations in the reported studies. Importantly, studies in the last three years have shown considerable progress in overcoming some of these limitations and identifying specific microRNAs as biomarkers for AD and mild cognitive impairment. Further large-scale human studies are warranted with less disparity in the study populations, and using an appropriate method to validate the findings. | Bridget Martinez Philip V.Peplow | 2019 | Neural Regeneration Research2019，14，2： | 18 |
| 20 | The utility of point-of-care ultrasound in the assessment of volume status in acute and critically ill patients显示文摘BACKGROUND:Volume resuscitation has only been demonstrated to be effective in approximately fifty percent of patients.The remaining patients do not respond to volume resuscitation and may even develop adverse outcomes(such as acute pulmonary edema necessitating endotracheal intubation).We believe that point-of-care ultrasound is an excellent modality by which to adequately predict which patients may benefi t from volume resuscitation.DATA RESOURCES:We performed a search using PubMed,Scopus,and MEDLINE.The following search terms were used:fluid responsiveness,ultrasound,non-invasive,hemodynamic,fluid challenge,and passive leg raise.Preference was given to clinical trials and review articles that were most relevant to the topic of assessing a patient’s cardiovascular ability to respond to intravenous fl uid administration using ultrasound.RESULTS:Point-of-care ultrasound can be easily employed to measure the diameter and collapsibility of various large vessels including the inferior vena cava,common carotid artery,subclavian vein,internal jugular vein,and femoral vein.Such parameters are closely related to dynamic measures of fluid responsiveness and can be used by providers to help guide fluid resuscitation in critically ill patients.CONCLUSION:Ultrasound in combination with passive leg raise is a non-invasive,costand time-effective modality that can be employed to assess volume status and response to fluid resuscitation.Traditionally sonographic studies have focused on the evaluation of large veins such as the inferior vena cava,and internal jugular vein.A number of recently published studies also demonstrate the usefulness of evaluating large arteries to predict volume status. | Ali Pourmand Matthew Pyle David Yamane Kazi Sumon Sarah E.Frasure | 2019 | World Journal of Emergency Medicine2019，10，4： | 18 |
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