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| 1 | Hepatocellular Carcinoma-Cause,Treatment and Metastasis显示文摘In the recent decades, the incidence of hepatocellular carcinoma (HCC) has been found to be increasing in males in some countries. In China, HCC ranked second of cancer mortality since 1990s. Hepatitis B and C viruses (HBV and HCV) and dietary aflatoxin intake remain the major causative factors of HCC. Surgery plays a major role in the treatment of HCC, particularly for small HCC. Downstaging unresectable huge HCC to smaller HCC and followed by resection will probably be a new approach for further study. Liver transplantation is indicated for small HCC, however, some issues remain to be solved.Different modes of 'regional cancer therapy for HCC' have been tried. Systemic chemotherapy has been disappointing in the past but the future can be promising.Biotherapy, such as cytokines, differentiation inducers,anti-angiogenic agents, gene therapy and tumor vaccine will probably play a role, particularly in the prevention of tumor recurrence. HCC invasiveness is currently the major target of study. Tremendous works have been done at the molecular level, which will provide clues for biomarker of HCC progressionas well as targets for intervention. | Zhao-You Tang Liver Cancer Institute & Zhongshan Hospital of Fudan University Professor of Surgery Chairman.Liver Cancer Institute of Fudan University(previous Liver Cancer Institute of Shanghai Medical University)136 Yixueyuan Road,Zhongshan Hospital,Shanghai 200032,China. | 2001 | World Journal of Gastroenterology2001，7，4： | 213 |
| 2 | Spatiotemporal variations of vegetation cover on the Chinese Loess Plateau(1981―2006):Impacts of climate changes and human activities显示文摘Spatiotemporal variations of Chinese Loess Plateau vegetation cover during 1981-2006 have been investigated using GIMMS and SPOT VGT NDVI data and the cause of vegetation cover changes has been analyzed, considering the climate changes and human activities. Vegetation cover changes on the Loess Plateau have experienced four stages as follows: (1) vegetation cover showed a continued increasing phase during 1981―1989; (2) vegetation cover changes came into a relative steady phase with small fluctuations during 1990―1998; (3) vegetation cover declined rapidly during 1999―2001; and (4) vegetation cover increased rapidly during 2002―2006. The vegetation cover changes of the Loess Plateau show a notable spatial difference. The vegetation cover has obviously increased in the Inner Mongolia and Ningxia plain along the Yellow River and the ecological rehabilitated region of Ordos Plateau, however the vegetation cover evidently decreased in the hilly and gully areas of Loess Plateau, Liupan Mountains region and the northern hillside of Qinling Mountains. The response of NDVI to climate changes varied with different vegetation types. NDVI of sandy land vegetation, grassland and cultivated land show a significant increasing trend, but forest shows a decreasing trend. The results obtained in this study show that the spatiotemporal variations of vegetation cover are the outcome of climate changes and human activities. Temperature is a control factor of the seasonal change of vegetation growth. The increased temperature makes soil drier and unfavors vegetation growth in summer, but it favors vegetation growth in spring and autumn because of a longer growing period. There is a significant correlation between vegetation cover and precipitation and thus, the change in precipitation is an important factor for vegetation variation. The improved agricultural production has resulted in an increase of NDVI in the farmland, and the implementation of large-scale vegetation construction has led to some beneficial effect in ecology. | XIN ZhongBao1,2, XU JiongXin1 & ZHENG Wei1, 2 1 Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China 2 Graduate University of the Chinese Academy of Sciences, Beijing 100049, China | 2008 | Science China Earth Sciences2008，51，1： | 112 |
| 3 | 基因重组人生长激素儿科临床规范应用的建议显示文摘1985年,基因重组人生长激素(recombinant human growth hormone,rhGH)问世,为广大矮身材患儿的治疗带来希望。随后,rhGH在临床得到迅速应用,其治疗的有效性得到广泛验证,关于rhGH的治疗范围、治疗方案、疗效以及安全性的研究日益深入。为规范rhGH的应用及矮身材儿童的诊治, | | 2013 | 中华儿科杂志2013，51，6： | 117 |
| 4 | 急性缺血性脑卒中早期血管内介入治疗流程与规范专家共识显示文摘缺血性脑卒中是目前我国最主要的致死致残病因之一,而其中颅内外大血管急性闭塞是缺血性脑卒中病情严重、预后不良的亚型,导致了巨大的社会和经济负担。4.5h内静脉应用重组组织型纤溶酶原激活剂(recombinant human tissue type plasminogen activator,rt.PA)作为处理急性缺血性脑卒中证据最充分的治疗方式,已在世界范围内广泛开展;但限于其相对严格的时间窗和适应证、禁忌证要求,接受溶栓治疗的患者比例相对较低。 | 中华医学会神经病学分会 中华医学会神经病学分会神经血管介入协作组 | 2017 | 中华神经科杂志2017，50，3： | 92 |
| 5 | 不同手术方式治疗剖宫产瘢痕妊娠术后人绒毛膜促性腺激素的变化趋势显示文摘目的 探讨不同手术方式治疗剖宫产瘢痕妊娠的临床疗效、术后人绒毛膜促性腺激素β亚单位(β-hCG)下降趋势及不同治疗方法的适应证.方法 通过前瞻性队列研究,对2013年6月至2014年12月在北京妇产医院计划生育科,采用不同手术方式治疗的120例剖宫产瘢痕妊娠患者的临床资料进行分析,120例中7例行B超下清宫术,63例行子宫动脉栓塞术(UAE)+宫腔镜下妊娠胚物清除术,41例行UAE+B超或腹腔镜监测下宫腔镜下妊娠胚物清除术,9例行UAE+宫腹腔镜联合瘢痕妊娠切除及子宫修补术,分析不同手术方式的临床疗效及术后不同时期血hCG的下降趋势.结果 (1)剖宫产瘢痕妊娠患者不同手术方式治疗术后48 h、术后1周及术后2周血β-hCG下降百分比的平均值分别为(84.5±9.7)%、(97.7±3.2)%及(99.6±1.2)%,术后血β-hCG水平降至正常时间为(22.4 ±6.7)d.(2)不同手术方式治疗后患者出血量及住院时间差异有统计学意义.(3)血β-hCG下降百分比在不同手术方法与术后恢复时间的交互作用分析差异有统计学意义(P<0.01),B超下清宫术后血β-hCG下降百分比低于其他组(P<0.05).结论 剖宫产瘢痕妊娠患者血β-hCG水平在术后3周左右降至正常水平;对于剖宫产瘢痕妊娠患者手术方式的选择,应依据胎囊着床瘢痕部位的程度、胎囊与子宫浆膜层最薄处肌层厚度、局部血流情况、血β-hCG水平、胎囊大小、突向膀胱情况及患者生育要求等来决定. | 胡乔飞 李长东 陈素文 李坚 | 2016 | 中华医学杂志2016，96，29： | 72 |
| 6 | Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis显示文摘AIM To evaluate the antifibrotic effect ofdifferent doses of recombinant human Gamma-Interferon (IFN-γ) intwo rat models of hepaticfibrosis, and to observe its effect on moderatechronic hepatitis B virus fibrosis.METNODS Hepatic fibrosis was successfullyinduced in 150 and 196 rats by subcutaneousinjection of carbon tetrachloride (CCl4) andintraperitoneal injection of dimethylnitrosamine(DMN), respectively. Each of the two modeldose IFN-γ group (15 MU/kg per day, i.m. for 8group (1.67 MU/kg daily, i.m. for 8 weeks).Another group of 10 rats without any treatmentwas used as normal controls. At the end of theexperiment, semi-quantitative histopathologicalscores of inflammation and fibrosis, liver (αsmooth muscle actin (α-SMA) expression level,liver hydroxyl proline content and serumhyaluronic acid levels were compared. And 47medium chronic hepatitis B viral fibrosispatients were studied. They were given IFN-γtreatment, 100MU/day i.m. for the first threemonths and 100MU qod i.m. for the next sixmonths. Semi-quantitative pathological scoresof inflammation and fibrosis and serum hepaticfibrosis indices were compared within the 9months.RESULTS In animal experiment, thepathological fibrosis scores and liver hydroxylproline content were found to be significantlylower in rats treated with different doses of IFN-γ as compared with rats in fibrotic model groupinduced by either CCI4 or DMN, in a dose-dependent manner. For CCI4-induced model,pathological fibrosis scores in high, medium andIow doses IFN-γ groups were 5.10 ± 2.88, 7.70 ±3.53 and 8.00 ± 3.30, respectively, but the scorewas 14.60 ± 7.82 in fibrotic model group.Hydroxyl proline contents were 2.83 ± 1.18, 3.59± 1.22 and 4.80 ± 1.62, in the three IFN-γgroups, and 10.01 ± 3.23 in fibrotic model group.The difference was statistically significant(P<0.01). Similar results were found in DMN-induced model. Pathological fibrosis scoreswere 6.30±0.48, 8.10 ±2.72 and 8.30 ±2.58, inhigh, medium and Iow doses IFN-γ groups, and12.60 ± 3.57 in fibrotic model group. Hydroxylproline contents were 2.72 ± 0.58, 3.14 ± 0.71and 3.62 ± 1.02, in the three IFN-γ groups, and12.79 ± 1.54 in fibrotic model group. Thedifference was statistically significant(P<0.01). Serum hepatic fibrosis indicesdecreased significantly in the 47 patients afterIFN-γ treatment (HA: 433.38 ± 373.00 vs 281.57± 220.48; LN: 161.22± 41.02 vs 146.35 ± 44.67;PCⅢ: 192.59 ± 89.95 vs 156.98 ± 49.22; C-Ⅳ:156.30 ± 44.01 vs 139.14 ± 34.47) and thedifferences between the four indices weresignificant (P<0.05). Thirty-three patientsCONCLUSION All the three doses of IFN-γ areeffective in treating rat liver fibrosis induced byeither CCl4 or DMN, the higher the dose, thebetter the effect. And IFN-γ is effective forpatients with moderate chronic hepatitis B viralfibrosis. | Hong Lei Weng Wei Min Cai Rong Hua Liu Institute of Infectious Diseases, First Affiliated Hospital. Medical School. Zhejiang University, Hangzhou 310003, Zhejiang Province. China | 2001 | World Journal of Gastroenterology2001，7，1： | 53 |
| 7 | 虚拟中国人女性一号肝脏图像三维重建和虚拟手术的切割显示文摘目的研究数字化虚拟肝脏三维重建及虚拟肝脏手术的切割。方法采用数字化虚拟中国人女性一号(VirtualChineseHumanFemaleNo.1VCHF1)数据集中所有包含肝脏的连续图像,首先对组织切片图像进行配准后从中分割提取出肝实质、肝静脉、胆管、胆囊等组织的图像信息,然后应用可视化工具包(VisualizationToolkit,VTK)三维重建,建立肝脏表面及内部结构的三维形态模型,并开发一个基于PC机和Windows平台的肝脏三维可视化演示系统。结果在肝脏三维可视化演示系统中,肝脏实体立体感强,可以通过设定肝脏及其管道系统的透明度,以及对模型的放大、缩小和上下左右不同方向的旋转,来观察肝脏及管道结构的立体形态。并可以按任意角度对虚拟的肝脏进行切割和观察切割面结构。结论利用VCHF1数据集中肝脏图像,在VTK基础上开发的基于PC机和Windows平台的肝脏三维可视化演示系统基本达到了比较满意的程度,为今后数字化虚拟肝脏及虚拟各种肝脏手术的研究做了积极探索。 | 方驰华 周五一 黄立伟 王博亮 钟世镇 | 2005 | 中华外科杂志2005，43，11： | 57 |
| 8 | 儿童腺病毒肺炎诊疗规范(2019年版)显示文摘结果人腺病毒(human adenovirus,HAdV)肺炎(以下简称腺病毒肺炎)是儿童社区获得性肺炎中较为严重的类型之一,多发于6个月至5岁儿童,部分患儿临床表现重,肺外并发症多,重症病例易遗留慢性气道和肺疾病,是目前造成婴幼儿肺炎死亡和致残的重要原因之一,需要高度关注。为进一步加强医疗救治和临床管理,提高重症病例救治能力和规范化诊疗水平,国家卫生健康委和国家中医药局组织多学科专家,针对腺病毒肺炎制定本诊疗规范。 | 无 | 2019 | 传染病信息2019，32，4： | 48 |
| 9 | Vaccination of poultry successfully eliminated human infection with H7N9 virus in China显示文摘The H7 N9 viruses that emerged in China in 2013 were nonpathogenic in chickens but mutated to a highly pathogenic form in early 2017 and caused severe disease outbreaks in chickens. The H7 N9 influenza viruses have caused five waves of human infection, with almost half of the total number of human cases(766 of 1,567) being reported in the fifth wave, raising concerns that even more human infections could occur in the sixth wave. In September 2017, an H5/H7 bivalent inactivated vaccine for chickens was introduced, and the H7 N9 virus isolation rate in poultry dropped by 93.3% after vaccination. More importantly,only three H7 N9 human cases were reported between October 1, 2017 and September 30, 2018, indicating that vaccination of poultry successfully eliminated human infection with H7 N9 virus. These facts emphasize that active control of animal disease is extremely important for zoonosis control and human health protection. | Xianying Zeng Guobin Tian Jianzhong Shi Guohua Deng Chengjun Li Hualan Chen | 2018 | Science China(Life Sciences)2018，61，12： | 37 |
| 10 | 物联网安全模型及关键技术显示文摘 | 刘宴兵 胡文平 | 2010 | 数字通信2010，37，4： | 34 |
| 11 | 微炎症状态与肾性贫血显示文摘肾性贫血是慢性。肾衰竭(chronic renal failure,CRF)的主要并发症,与不良的心血管事件和总体预后差相关。目前临床上通过补充重组人红细胞生成素(recombinant human erythropoietinr,HuEPO)及铁剂治疗肾性贫血,疗效确切,但仍有部分患者给予充足治疗后效果不佳。 | 窦涪琳 王杨威 崔文鹏 董文鹏 张艺献 苗里宁 | 2016 | 中国血液净化2016，15，3： | 34 |
| 12 | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China显示文摘Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. | Shuang Zhao Xuelian Zhao Shangying Hu Jessica Lu Xianzhi Duan Xun Zhang Feng Chen Fanghui Zhao | 2019 | Chinese Journal of Cancer Research2019，31，4： | 30 |
| 13 | Correlation of human epidermal growth factor receptor 2 expression with clinicopathological characteristics and prognosis in gastric cancer显示文摘AIM:To investigate human epidermal growth factor receptor 2(HER2) gene amplification and protein expression in Chinese patients with resectable gastric cancer and the association with clinicopathological characteristics and survival.METHODS:One hundred and ninety-seven gastric cancer patients who underwent curative surgery procedures were enrolled into this study.HER2 gene amplification and protein expression were examined using fluorescence in-situ hybridization(FISH) and immunohistochemistry(IHC) analysis on formalin-fixed paraffinembedded gastric cancer samples from all patients.For scoring,Hofmann's HER2 gastric cancer scoring system was adopted.All cases showing IHC3+ or FISH positiv-ity were defined as HER2 positive.Patient clinicopathological data and survival information were collected.Finally,χ 2 statistical analysis was performed to analyze the HER2 positivity rate amongst the subgroups with different clinicopathological characteristics including;gender,age,tumor location,Lauren classification,differentiation,TNM staging,depth of invasion,lymph node metastases and distant metastasis.The probability of survival for different subgroups with different clinicopathological characteristics was calculated using the Kaplan-Meier method and survival curves plotted using log rank inspection.RESULTS:According to Hofmann's HER2 gastric cancer scoring criteria,31 cases(15.74%) were identified as HER2 gene amplified and 19 cases(9.64%) were scored as strongly positive for HER2 membrane staining(3+),25 cases(12.69%) were moderately positive(2+) and 153 cases(77.66%) were HER2 negative(0/1+).The concordance rate between IHC and FISH analyses was 88.83%(175/197).Thirty-six cases were defined as positive for HER2 gene amplification and/or protein expression,with 24 of these cases being eligible for Herceptin treatment according to United States recommendations,and 29 of these cases eligible according to EU recommendations.Highly consistent results were detected between IHC3+,IHC0/1 and FISH(73.68% and 95.42%),but low consistency was observed between IHC2+ and FISH(40.00%).The positivity rates in intestinal type and well-differentiated gastric cancer were higher than those in diffuse/mixed type and poorly-differentiated gastric cancer respectively(28.57% vs 13.43%,P = 0.0103;37.25% vs 11.64%,P < 0.0001),but were not correlated with gender,age,tumor location or TNM stage,depth of invasion,lymph node metastases and distant metastasis.In poorly-differentiated gastric cancer patients,those without lymph node metastasis showed a higher HER2 positivity rate than those with lymph node metastasis(26.47% vs 7.14%,P = 0.0021).This association was not present in thosepatients with well-differentiated gastric cancer(28.57% vs 43.33%,P = 0.2832).Within our patient cohort,26 cases were lost to follow-up.The median survival time for the remaining 171 patients was 18 mo.The median survival times of the HER2 positive and negative groups were 17 and 18.5 mo respectively.Overall survival was not significantly different between HER2-positive and negative groups(χ 2 = 0.9157,P = 0.3386),but in patients presenting well-differentiated tumors,the overall survival of the HER2-positive group was significantly worse than that of the HER2-negative group(P = 0.0123).In contrast,patients with poorly differentiated and diffuse/mixed subtype gastric cancers showed no significant differences in overall survival associated with HER2.Furthermore,the median survival time of the HER2 positive group did not show any statistically significant differences when compared to the subgroups of gender,age,tumor location,TNM classification,lymph node metastases and distant metastasis.CONCLUSION:Patients with intestinal type gastric cancer(GC),well-differentiated GC and poorly-differentiated GC without lymph node metastasis,may all represent suitable candidates for targeted therapy using Herceptin. | Chao He Xue-Yi Bian Xing-Zhi Ni Dan-Ping Shen Yan-Ying Shen Hua Liu Zhi-Yong Shen Qiang Liu | 2013 | World Journal of Gastroenterology2013，19，14： | 28 |
| 14 | 我国Living library研究述评显示文摘Living library(又称为'Human Library''、真人图书馆'和'活体图书馆')自2000年在丹麦产生以来,它以新颖的服务模式创新了图书馆工作,我国图书馆界近年来也对'Living library'在国内外的发展与实践开展做了介绍研究,对Living library在我国的开展意义与发展对策也做了初步的探索。 | 袁纳宇 | 2011 | 图书与情报2011，，4： | 27 |
| 15 | Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle,Fujian Province显示文摘AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 ( CYP2 E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitroscoamines and Iow molecular weight organic compounds. The purpose of this study is to determine whether CYP450 2Elpolymorphisms are associated with risk s of gastric cancer.METHODS: We conducted a population based case-control study in Changle county, Fujian Province, a high-risk region of gastric cancer in China. Ninety-one incident gastric cancer patients and ninety-four healthy controls were included in our study. Datas including dsmographic characteristcs, diet intake, and alcohol and tobacco consumption of indivduals in our study were completed by a standardized questionnaire. PCR-RFLP revealed three genotypes: heterozygote (C1/C2) and two homozygotes (C1/C1 and C2/C2) in CYP2E1.RESULTS: The frequency of variant genotypes (C1/C2 and C2/C2) in gastric cancer cases and controls was 36.3% and 24.5%, respectively. The rare homozygous C2/C2 genotype was found in 6 indivduals in gastric cancer group(6.6%),whereas there was only one in the control group (1.1%).However, there was no statistically significan difference between the two groups (two-tailed Fisher′s exact test, P =0.066). Indivduals in gastric cancer group were more likely to carry genotype C1/C2 (odds ratio, OR = 1.50) and C2/C2(OR = 7.34) than indivduals in control group (X2 = 4.597, for trend P=0.032). The frequencies of genofypes with the C2allele ( C1/C2 and C2/C2 genotypes) were compared with those of genotypes without C2 allele ( C1/C1 genotype )among indivduals in gastric cancer group and control group according to the pattern of gastric cancer risk factors. The results show that indivduals who exposed to these gastric cancer risk factors and carry the C2 allele seemed to have a higher risk of developing gastric cancer.CONCLUSION: Polymorphism of CYP2E1 gene may have some effct in the development of gastric cancer in Changle county, Fujian Province. | Lin Cai~1 Shun-Zhang Yu~2 Zuo-Feng Zhang~3 1 Department of Epidemiology,Fujian Medical University,Fuzhou 350004,Fujian Province,China2 Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA | 2001 | World Journal of Gastroenterology2001，7，6： | 25 |
| 16 | 关于修改后刑事诉讼法执行情况的若干思考显示文摘《人民检察》2015年第7期刊登了最高人民检察院副检察长孙谦同志的'关于修改后刑事诉讼法执行情况的若干思考'一文,现予转载,以飨读者。 | 孙谦 | 2015 | 国家检察官学院学报2015，23，3： | 25 |
| 17 | 难治性心力衰竭的内科治疗进展显示文摘难治性心力衰竭( refractory heart failure , RHF)是终末期心血管病常见的并发症,由于病理生理机制复杂,单一药物治疗难度极大。目前,通过传统药物的联合治疗,米力农、重组人脑利钠肽( recombinant human brain natriuretic peptide , rh-BNP)和左西孟旦等新型药物的临床运用,血液净化、主动脉球囊反搏、心室辅助装置和体外模肺氧合等脏器支持的实施,RHF救治成功率得到提高。本文就近年来RHF内科治疗进展进行综述。 | 陈怿(综述) 童华生 江东新 苏磊(审校) | 2014 | 中国急救医学2014，34，8： | 26 |
| 18 | Application of metagenomics in the human gut microbiome显示文摘There are more than 1000 microbial species living in the complex human intestine.The gut microbial community plays an important role in protecting the host against pathogenic microbes,modulating immunity,regulating metabolic processes,and is even regarded as an endocrine organ.However,traditional culture methods are very limited for identifying microbes.With the application of molecular biologic technology in the field of the intestinal microbiome,especially metagenomic sequencing of the next-generation sequencing technology,progress has been made in the study of the human intestinal microbiome.Metagenomics can be used to study intestinal microbiome diversity and dysbiosis,as well as its relationship to health and disease.Moreover,functional metagenomics can identify novel functional genes,microbial pathways,antibiotic resistance genes,functional dysbiosis of the intestinal microbiome,and determine interactions and co-evolution between microbiota and host,though there are still some limitations.Metatranscriptomics,metaproteomics and metabolomics represent enormous complements to the understanding of the human gut microbiome.This review aims to demonstrate that metagenomics can be a powerful tool in studying the human gut microbiome with encouraging prospects.The limitations of metagenomics to be overcome are also discussed.Metatranscriptomics,metaproteomics and metabolomics in relation to the study of the human gut microbiome are also briefly discussed. | Wei-Lin Wang Shao-Yan Xu Zhi-Gang Ren Liang Tao Jian-Wen Jiang Shu-Sen Zheng | 2015 | World Journal of Gastroenterology2015，21，3： | 26 |
| 19 | Inhibiting effect of Endostar combined with ginsenoside Rg3 on breast cancer tumor growth in tumor-bearing mice显示文摘Objective: To study the inhibiting effect of Endostar combined with ginsenoside Rg3 on breast cancer tumor growth in tumor-bearing mice. Methods: Female mice were selected as experimental animals, and breast cancer tumor-bearing mouse models were established and then divided into group A, B, C and D that respectively received saline, recombinant human endostatin, ginsenosides Rg3 and recombinant human endostatin combined with Rg3 intervention; 7 d, 14 d and 21 d after intervention, tumor tissue volume was measured; 21 d after intervention, mice were killed, tumor tissue was collected, and m RNA contents of angiogenesis molecules, invasion molecules, autophagy marker molecules and autophagy signaling pathway molecules were detected. Results: At 7 d, 14 d and 21 d after intervention, tumor tissue volume of group B, C and D was lower than that of group A, and tumor tissue volume of group D was lower than that of group B and C; m RNA contents of VEGFA, VEGFB, VEGFC, MMP2, MMP9, p62, m TOR, PI3 K, Akt, JNK and Beclin-1 in tumor tissue of group B, C and D were significantly lower than those of group A, and LC3-II/LC3-I was significantly higher than that of group A; m RNA contents of VEGFA, VEGFB, VEGFC, MMP2, MMP9, p62, m TOR, PI3 K, Akt, JNK and Beclin-1 in tumor tissue of group D were significantly lower than those of group B and C, and LC3-II/LC3-I was higher than that of group B and C. Conclusions: Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy. | Yun Zhang Qing-Zhan Liu Su-Ping Xing Jin-Ling Zhang | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，2： | 24 |
| 20 | Lake sediment records on climate change and human activities since the Holocene in Erhai catchment, Yunnan Province, China显示文摘According to high-resolution analyses on multi-proxy of sediment core from the Er- hai Lake, Yunnan Province, the sequence of climatic and environmental change since the Holo- cene has been reconstructed based on accurate dating. The results show that climate had tran- sited from cold-wet to warm-wet during ca. 12950-8399 aBP in this area, and the transition happened in ca. 10329 aBP. Due to the enhancing southwest Asian monsoon and increasing precipitation, the lake-level of the Erhai Lake began to rise after ca. 10329 a BP. Climate in the catchment was warm and wet during the mid-Holocene, and the warmest stage appeared in ca. 8399-6371 a BP. The lake-level descended in the mid-Holocene because of the decrease of effective moisture in the basin. Human activities appeared in ca. 6371 a BP, and the initial man- ner mainly focused on deforestation. Up to ca. 2139 a BP, due to the amount of immigration into this area, the cultivation was developed widely, which was followed by mining (coal mine). | R. Matsumoto | 2005 | Science China Earth Sciences2005，48，3： | 22 |
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