|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human Cyber Physical Systems(HCPSs)in the Context of New-Generation Intelligent Manufacturing显示文摘An intelligent manufacturing system is a composite intelligent system comprising humans,cyber systems,and physical systems with the aim of achieving specific manufacturing goals at an optimized level.This kind of intelligent system is called a human-cyber-physical system(HCPS).In terms of technology,HCPSs can both reveal technological principles and form the technological architecture for intelligent manufacturing.It can be concluded that the essence of intelligent manufacturing is to design,construct,and apply HCPSs in various cases and at different levels.With advances in information technology,intelligent manufacturing has passed through the stages of digital manufacturing and digital-networked manufacturing,and is evolving toward new-generation intelligent manufacturing(NGIM).NGIM is characterized by the in-depth integration of new-generation artificial intelligence(AI)technology(i.e.,enabling technology)with advanced manufacturing technology(i.e.,root technology);it is the core driving force of the new industrial revolution.In this study,the evolutionary footprint of intelligent manufacturing is reviewed from the perspective of HCPSs,and the implications,characteristics,technical frame,and key technologies of HCPSs for NGIM are then discussed in depth.Finally,an outlook of the major challenges of HCPSs for NGIM is proposed. | Zhou Ji Zhou Yanhong Wang Baicun Zang Jiyuan | 2019 | Engineering2019，5，4： | 98 |
| 2 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 3 | 中国区域物流业与经济发展协调度研究--基于复合系统模型与30个省区面板数据显示文摘采用复合系统模型计算了全国30个省(区)物流业子系统与经济子系统的有序度,在此基础上得出了全国与东、中、西3个地区各子系统有序度和复合系统协调度,并进一步分析了经济最发达的4个区域的协调度在研究时段内的变化情况。结果显示对物流业子系统贡献最大的序参量是周转量,受各个地方政府2005年加大物流业投入影响,物流业固定资产投资对物流业子系统贡献也明显上升。对经济子系统而言,城镇与农村居民恩格尔系数与人均工资先后对经济子系统贡献最大。总体上,东、中、西3个地区协调度呈上升趋势。 | 张毅 陈圻 | 2010 | 软科学2010，24，12： | 68 |
| 4 | A CLASS OF NONLOCAL BOUNDARY VALUE PROBLEMS OF NONLINEAR ELLIPTIC SYSTEMS IN UNBOUNDED DOMAINS显示文摘The nonlocal boundary value problems for nonlinear elliptic systems in the unbounded domain are considered. Under suitable conditions the existence of solution and comparison theorem for the boundary value problems are studied. | 莫嘉琪 欧阳成 | 2001 | Acta Mathematica Scientia2001，21，1： | 64 |
| 5 | 创新2.0时代众创空间的生态模式——国内外比较及启示显示文摘"众创空间"是创新2.0时代创新创业服务机构的集合式概念,是由创客空间、孵化器、加速器等组成的创新新创业服务生态系统。创新2.0时代,欧美国家正积极探索众创空间生态模式,逐渐建立起"创客空间+孵化器+智能化创新(Living Lab)"的垂直、多元化众创空间生态主体结构。相比之下,我国众创空间生态体系尚不健全,"孵化器"一元主导的结构模式明显,在众创空间发展模式、经营主体、功能绩效等方面与国外众创空间存在较大差距。创新2.0时代,我国应积极借鉴国外众创空间发展经验,布局社区化创客空间,建立创新创业智能化升级机制,延长创新创业服务链条,完善众创空间生态体系;积极推进创新创业服务机构市场化改革,发展创新创业服务中介组织,提升众创空间专业化水平,形成市场为主、政府为辅的多元化众创空间新形态,建立起中国特色的众创空间生态体系。 | 解学芳 刘芹良 | 2018 | 科学学研究2018，36，4： | 66 |
| 6 | Theoretical research on construction quality real-time monitoring and system integration of core rockfill dam显示文摘With the enlargement of core rockfill dam construction scale and the improvement of construction mechanization level, the traditional manual construction quality control method is now difficult to meet the quality and safety demands of modern dam construction, so automatic and real-time dam construction quality monitoring with high-techs is urgently needed. The paper makes theoretical research on construction quality real-time monitoring and system integration of core rockfill dam, proposes implementation method and integrated solution of construction quality real-time monitoring of core rockfill dam construction process, realizes refining, all-whether, entire-process and real-time control and analysis on key links of dam construction, and introduces the application of the construction quality real-time monitoring and system integration technology to a practical core rockfill dam project. | ZHONG DengHua CUI Bo LIU DongHai TONG DaWei | 2009 | Science China(Technological Sciences)2009，52，11： | 59 |
| 7 | New advances in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the leading cause of deaths in cirrhotic patients and the third cause of cancer related deaths.Most HCC are associated withwell known underlying risk factors,in fact,HCC arise in cirrhotic patients in up to 90%of cases,mainly due to chronic viral hepatitis and alcohol abuse.The worldwide prevention strategies are conducted to avoid the infection of new subjects and to minimize the risk of liver disease progression in infected patients.HCC is a condition which lends itself to surveillance as at-risk individuals can readily be identified.The American and European guidelines recommended implementation of surveillance programs with ultrasound every six months in patient atrisk for developing HCC.The diagnosis of HCC can be based on non-invasive criteria(only in cirrhotic patient)or pathology.Accurately staging patients is essential to oncology practice.The ideal tumour staging system in HCC needs to account for both tumour characteristics and liver function.Treatment allocation is based on several factors:Liver function,size and number of tumours,macrovascular invasion or extrahepatic spread.The recommendations in terms of selection for different treatment strategies must be based on evidence-based data.Resection,liver transplant and interventional radiology treatment are mainstays of HCC therapy and achieve the best outcomes in well-selected candidates.Chemoembolization is the most widely used treatment for unresectable HCC or progression after curative treatment.Finally,in patients with advanced HCC with preserved liver function,sorafenib is the only approved systemic drug that has demonstrated a survival benefit and is the standard of care in this group of patients. | Sonia Pascual Iván Herrera Javier Irurzun | 2016 | World Journal of Hepatology2016，8，9： | 51 |
| 8 | Brain-gut-microbiota axis in Parkinson's disease显示文摘Parkinson's disease(PD) is characterized by alphasynucleinopathy that affects all levels of the braingut axis including the central, autonomic, and enteric nervous systems. Recently, it has been recognized that the brain-gut axis interactions are significantly modulated by the gut microbiota via immunological,neuroendocrine, and direct neural mechanisms. Dysregulation of the brain-gut-microbiota axis in PD may be associated with gastrointestinal manifestations frequently preceding motor symptoms, as well as with the pathogenesis of PD itself, supporting the hypothesis that the pathological process is spread from the gut to the brain. Excessive stimulation of the innate immune system resulting from gut dysbiosis and/or small intestinal bacterial overgrowth and increased intestinal permeability may induce systemic inflammation, while activation of enteric neurons and enteric glial cells may contribute to the initiation of alpha-synuclein misfolding.Additionally, the adaptive immune system may be disturbed by bacterial proteins cross-reacting with human antigens. A better understanding of the brain-gutmicrobiota axis interactions should bring a new insight in the pathophysiology of PD and permit an earlier diagnosis with a focus on peripheral biomarkers within the enteric nervous system. Novel therapeutic options aimed at modifying the gut microbiota composition and enhancing the intestinal epithelial barrier integrity in PD patients could influence the initial step of the following cascade of neurodegeneration in PD. | Agata Mulak Bruno Bonaz | 2015 | World Journal of Gastroenterology2015，21，37： | 60 |
| 9 | 基于软件仿真的通信原理实验教学显示文摘围绕通信原理实验教学的现状,提出了基于3种仿真软件SystemView、Matlab和LabVIEW的实验体系,软件仿真技术正日益融入许多经典的专业基础课教学中,软件仿真实验内容灵活、设计性强,既与基本理论相互补充,又能与硬件实验相互弥补。实践结果表明,教学效果好,学生学习有兴趣和热情,具有很好的推广和借鉴价值。 | 孙爱晶 刘毓 | 2010 | 实验室研究与探索2010，29，1： | 44 |
| 10 | Stress changes on major faults caused by M_w7.9 Wenchuan earthquake,May 12,2008显示文摘On May 12,2008,a magnitude 7.9 earthquake ruptured the Longmenshan fault system in Sichuan Province,China,collapsing buildings and killing tens of thousands people.As predicted,aftershocks may last for at least one year,and moreover,large aftershocks are likely to occur.Therefore,it is critical to outline the areas with potential aftershocks before reconstruction and resettling people as to avoid future disasters.It is demonstrated that the redistribution of stress induced by an earthquake should trigger successive seismic activity.Based on static stress triggering theory,we calculated the coseismic stress changes on major faults induced by the Wenchuan earthquake,with elastic dislocation the-ory and the multilayered crustal model.We also discuss the stress distribution and its significance for future seismic activity under the impact of the Wenchuan earthquake.It is shown that coulomb failure stress(CFS) increases obviously on the Daofu-Kangding segment of the Xianshuihe Fault,the Maqu and Nanping segment of the Eastern Kunlun Fault,the Qingchuan Fault,southern segment of the Min-jiang Fault,Pengxian-Guanxian Fault,Jiangyou-Guangyuan Fault,and Jiangyou-Guanxian Fault.The increased stress raises the probability of earthquake occurrence on these faults.Since these areas are highly populated,earthquake monitoring and early disaster alarm system are needed.CFS increases with a magnitude of 0.03―0.06 MPa on the Qingchuan Fault,which is close to the northern end of the rapture of Wenchuan earthquake.The occurrence of some strong aftershocks,including three events with magnitude higher than 5.0,indicates that the seismic activities have been triggered by the main shock.Aftershocks seem to migrate northwards.Since the CFS change on the Lueyang-Mianxian Fault located on the NEE of the Qingchuan Fault is rather small(±0.01 MPa),the migration of aftershocks might be terminated in the area near Hanzhong City.The CFS change on the western Qinling Fault is around 10 Pa,and the impact of static triggering can be neglected.The increment of CFS on the Pengxian-Guanxian Fault and Beichuan-Yingxiu Fault southwest to the main rupture is 0.005―0.015 MPa,which would facilitate earthquake triggering in these areas.Very few aftershocks in these areas indicate that the accumulated stress has not been released sufficiently.High seismic risk is predicated in these areas due to coseismic CFS loading.The Wenchuan earthquake released the accumulated CFS on the Fubianhe Fault,the Huya Fault,the Ha'nan-Qingshanwan Fault,and the Diebu-Bailongjiang Fault.The decrement of CFS changes on the Longquanshan Fault east to Chengdu City is about 0.002 MPa.The seismic activity will be depressed by decrement of CFS on these faults. | SHAN Bin XIONG Xiong ZHENG Yong DIAO FaQi | 2009 | Science China Earth Sciences2009，52，5： | 47 |
| 11 | Blog技术在教育信息化中的应用研究显示文摘教育信息化是在教育领域全面深入地运用现代信息技术改造教育,促进教育改革和发展的过程,是教育领域的一场新技术革命.在Internet和Web技术迅速发展的今天,教育信息化已经与网络这一大环境息息相关. | 于斌 | 2005 | 计算机教育2005，，5： | 46 |
| 12 | 卒中后认知功能康复与神经可塑性显示文摘 | 尹义臣 陈卓铭 杜志宏 | 2005 | 中国康复医学杂志2005，20，6： | 44 |
| 13 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 14 | Gut microbiota and liver diseases显示文摘Several studies revealed that gut microbiota are associated with various human diseases,e.g.,metabolic diseases,allergies,gastroenterological diseases,and liver diseases.The liver can be greatly affected by changes in gut microbiota due to the entry of gut bacteria or their metabolites into the liver through the portal vein,and the liver-gut axis is important to understand the pathophysiology of several liver diseases,especially non-alcoholic fatty liver disease and hepatic encephalopathy.Moreover,gut microbiota play a significant role in the development of alcoholic liver disease and hepatocarcinogenesis.Based on theseprevious findings,trials using probiotics have been performed for the prevention or treatment of liver diseases.In this review,we summarize the current understanding of the changes in gut microbiota associated with various liver diseases,and we describe the therapeutic trials of probiotics for those diseases. | Masami Minemura Yukihiro Shimizu | 2015 | World Journal of Gastroenterology2015，21，6： | 41 |
| 15 | Prediction of permafrost distribution on the Qinghai-Tibet Plateau in the next 50 and 100 years显示文摘Intergovernmental Panel on Climate Change (IPCC) in 2001 reported that the Earth air temperature would rise by 1.4-5.8℃ and 2.5℃ on average by the year 2100. China re-gional climate model results also showed that the air temperature on the Qinghai-Tibet Plateau (QTP) would increase by 2.2-2.6℃ in the next 50 years. A numerical permafrost model was developed to predict the changes of permafrost distribution on the QTP over the next 50 and 100 years under the two climatic warming scenarios, i.e. 0.02℃/a, the lower value of IPCC’s estima-tion, and 0.052℃/a, the higher value predicted by Qin et al. Simulation results show that ( i ) in the case of 0.02℃/a air-temperature rise, permafrost area on the QTP will shrink about 8.8% in the next 50 years, and high temperature permafrost with mean annual ground temperature (MAGT) higher than ?0.11℃ may turn into seasonal frozen soils. In the next 100 years, perma-frost with MAGT higher than ?0.5℃ will disappear and the permafrost area will shrink up to 13.4%. (ii) In the case of 0.052℃/a air-temperature rise, permafrost area on the QTP will reduce about 13.5% after 50 years. More remarkable degradation will take place after 100 years, and permafrost area will reduce about 46%. Permafrost with MAGT higher than ?2℃ will turn into seasonal frozen soils and even unfrozen soils. | NAN Zhuotong LI Shuxun CHENG Guodong | 2005 | Science China Earth Sciences2005，48，6： | 40 |
| 16 | 亚言语的理论与应用显示文摘成晓光,辽 宁 师 范 大 | 成晓光 | 1999 | 外语与外语教学1999，，9： | 39 |
| 17 | Sedation in gastrointestinal endoscopy: Current issues显示文摘Diagnostic and therapeutic endoscopy can successfully be performed by applying moderate(conscious) sedation.Moderate sedation,using midazolam and an opioid,is the standard method of sedation,although propofol is increasingly being used in many countries because the satisfaction of endoscopists with propofol sedation is greater compared with their satisfaction with conventional sedation.Moreover,the use of propofol is currently preferred for the endoscopic sedation of patients with advanced liver disease due to its short biologic half-life and,consequently,its low risk of inducing hepatic encephalopathy.In the future,propofol could become the preferred sedation agent,especially for routine colonoscopy.Midazolam is the benzodiazepine of choice because of its shorter duration of action and better pharmacokinetic profile compared with diazepam.Among opioids,pethidine and fentanyl are the most popular.A number of other substances have been tested in several clinical trials with promising results.Among them,newer opioids,such as remifentanil,enable a faster recovery.The controversy regarding the administration of sedation by an endoscopist or an experienced nurse,as well as the optimal staffing of en-doscopy units,continues to be a matter of discussion.Safe sedation in special clinical circumstances,such as in the cases of obese,pregnant,and elderly individuals,as well as patients with chronic lung,renal or liver disease,requires modification of the dose of the drugs used for sedation.In the great majority of patients,sedation under the supervision of a properly trained endoscopist remains the standard practice worldwide.In this review,an overview of the current knowledge concerning sedation during digestive endoscopy will be provided based on the data in the current literature. | John K Triantafillidis Emmanuel Merikas Dimitrios Nikolakis Apostolos E Papalois | 2013 | World Journal of Gastroenterology2013，19，4： | 35 |
| 18 | 西昆仑-塔西南坳陷晚古生代以来的沉积构造演化显示文摘自柯克亚深层油气勘探取得突破以来,塔西南坳陷一直受到各类地质学家的广泛关注,有关该盆地的形成和演化历史及其油气资源评价近年来更是成为人们的研究热点。本文在总结前人资料的基础上,探讨塔西南和西昆仑地区自晚古生代以来所经历的构造及沉积格架的演变过程,对塔西南坳陷性质及其演化阶段划分所存在的争议进行了归纳,分析了塔西南-西昆仑这一盆山体系形成和演化中的构造变形和沉积记录。总体来说,根据现有沉积和构造变形资料,中生代之前西昆仑和塔西南坳陷分别处于同一构造背景下的不同沉积单元;二者之间盆山体系的形成主要自晚侏罗世-早白垩世,中-上新世是造盆造山作用机制发生重大转折的时期,或者说早更新世末的构造运动基本上奠定了西昆仑-塔里木盆地南缘现今的盆-山构造格架。 | 方爱民 马建英 王世刚 赵越 胡健民 | 2009 | 岩石学报2009，25，12： | 40 |
| 19 | AO微创内固定系统治疗股骨远端骨折近期效果观察显示文摘[目的]报告AO微创内固定系统(1ess invasive stabilization system,LISS)治疗股骨远端骨折短期疗效,结合文献,着重探讨与手术相关问题.[方法]本组4例,均为男性,年龄36~53岁.左侧2例,右侧2例.汽车相撞车祸伤3例,重物压伤1例.骨折AO分型:A11例,A31例,C11例,C21例.开放性骨折1例.均应用股骨远端LISS内固定治疗.[结果]4例切口均Ⅰ期愈合,X线片复查骨折对位、对线良好.膝关节功能按Merchn等评分标准评定.优3例,良1例.[结论]LISS对股骨远端骨折是一种有效的微创内固定治疗方法,术中不需植骨,术后并发症少. | 黄长明 胡喜春 王剑敏 沈瑞群 王建雄 | 2005 | 中国矫形外科杂志2005，13，18： | 37 |
| 20 | Two series of copper-gold deposits in the middle and lower reaches of the Yangtze River area (MLYRA) and the hydrogen, oxygen, sulfur and lead isotopes of their ore-forming hydrothermal systems显示文摘Based on studies on the geological characteristics of the copper-gold deposits in the middle and lower reaches of the Yangtze River area (MLYRA) and their hydrogen, oxygen, sulfur and lead isotope compositions, it is concluded that there existed two series of copper-gold deposits. They are evolutional products of two ore-forming hydrothermal systems in different geodynamic settings and geological era. Series I is stratiform or stratabound copper-gold deposits. These deposits were formed by submarine exhalation and sedimentation of hydrothermal solutions in Her-cynian tensional tectonic environment after bot brine ascending along contemporaneous faults and exhaled into the sea-floor. Series II consists of copper-gold deposits related to medium and acidic magmatic intrusions. Their mineralizations took place in Yanshanian in a tensional or a transitional period to the tensional tectonic environment from the composite of the tethys tectonic regime and the Paleo-Pacific ocean tectonic regime, as well as | 周涛发 袁峰 岳书仓 赵勇 | 2000 | Science China Earth Sciences2000，43，S1： | 40 |
您所在的机构暂未开通此部分的功能，请联系管理员