Walled-off pancreatic necrosis

查看全文 作　　者：Michael [1]Stamatakos;Charikleia [1]Stefanaki;Konstantinos [2]Kontzoglou;Spyros [1]Stergiopoulos;Georgios [1]Giannopoulos;Michael [1]Safioleas 机构地区：[1]4th Department of Surgery, Medical School, University of Athens, Attikon Hospital, Athens, 12462, Greece;[2]2nd Department of Propaedeutic Surgery, Medical School, University of Athens, Laikon Hospital, Athens, 11527, Greece 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第14期,共6页 摘　　要：Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview of the continually expanding knowledge about WOPN, by review of current data from references identified in Medline and PubMed, to September 2009, using key words, such as WOPN, infected pseudocyst, severe pancreatitis, pancreatic abscess, acute necrotizing pancreatitis (ANP), pancreas, inflammation and alcoholism. WOPN comprises a later and local complication of ANP, occurring more than 4 wk after the initial attack, usually following development of pseudocysts and other pancreatic fluid collections. The mortality rate associated with WOPN is generally less than that of infected pancreatic necrosis. Surgical intervention had been the mainstay of treatment for infected peripancreatic fluid collection and abscesses for decades. Increasingly, percutaneous catheter drainage and endoscopic retrograde cholangiopancreatography have been used, and encourag-ing results have recently been reported in the medical literature, rendering these techniques invaluable in the treatment of WOPN. Applying the recommended therapeutic strategy, which comprises early treatment with antibiotics combined with restricted surgical intervention, fewer patients with ANP undergo surgery and interventions are ideally performed later in the course of the disease, when necrosis has become well demarcated. 关 键 词：Walled-off pancreatic necrosis Infected pseudocyst Severe pancreatitis Acute necrotizing pancreatitis PANCREAS Inflammation ALCOHOLISM