Metabolic investigations in patients with hepatitis B and C

查看全文 作　　者：Abdul Aziz [1]Mastoi;Bikha Ram [2]Devrajani;Syed Zulfiquar Ali [2]Shah;Qasim [2]Rohopoto;Sikander Ali [1]Memon;Marya [1]Baloch;Ghulam Ali [3]Qureshi;Waqas [4]Sami 机构地区：[1]M.A.Kazi Institute of Chemistry,University of Sind,Jamshoro 75000,Pakistan;[2]Department of Medicine,Liaquat University of Medical and Health Sciences,Jamshoro 75000,Pakistan;[3]Medical Research Centre,Liaquat University of Medical and Health Sciences,Jamshoro 75000, Pakistan;[4]Department of Biochemistry,University of Health Sciences,Lahore 54600,Pakistan 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第5期,共5页 摘　　要：AIM:To investigate the similarities and dissimilarities in patients with hepatitis B and hepatitis C,clinically and metabolically. METHODS:Fifty patients with hepatitis B virus and hepatitis C virus infection were included in this study, along with fifty healthy controls for comparison purposes.Intravenous blood(10 mL)samples from patients and healthy subjects were collected and made to clot before serum was separated and immediately levels of the enzymes,alkaline phosphatase(ALK),creatinine phosphokinase(CPK),lactate dehydrogenase (LDH),serum glutamate oxaloacetate transaminase(sGOT)and serum glutamate pyruvate transaminase(sGPT)were determined by a kit method.For total con-tent of each metal the serum samples were analyzed using atomic absorption spectrophotometry.Levels of cholesterol,triglycerides,urea,creatinine and uric acid were determined using a kit method on Microlab 300. RESULTS:Serum magnesium and copper levels remained unchanged,whereas the concentration of zinc decreased and iron increased significantly in both groups of patients.Total antioxidant activity was significantly decreased in both hepatitis B and C.Among the enzymes analyzed,ALK,s-GPT,LDH and s-GOT were all significantly increased in both patients with hepatitis B and C whereas CPK was significantly decreased in patients with hepatitis B and remained unchanged in patients with hepatitis C. CONCLUSION:The information accumulated by this study will help provide a better understanding of involved metabolic processes in order to design appropriate therapeutic approaches for treating these patients,so they can recover and lead normal lives. 关 键 词：Hepatitis B virus Hepatitis C virus Antioxidant activity Metal content Enzyme activity