Negative selection of murine medullary-type single positive thymocytes

查看全文 作　　者：TIAN Tian, ZHANG Jun, QIAN Xiaoping, GAO Ling and CHEN Weifeng(Department of Immunology, Peking University Health Science Center, Beijing 100083, China)

出　　处：《Progress in Natural Science:Materials International》索引2002年第12卷第5期,共5页

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 39730410); the Major State Basic Research Development Program of China (Grant No. 1999053904) 摘　　要：Negative selection depletes self-reactive T cells, thus ensuring self-tolerance. It is usually considered that negative selection imposed on double-positive (DP) thymocytes that reside at the cortico-medullary junction. Negative selection model was set up by injecting mice with anti-T cell receptor (TCR) monoclonal antibody (mAb) intraperitoneally in this work. As shown in phenotypic analysis of thymocytes, negative selection destroys not only cortical-type DP thymocytes, but also medullary-type CD3+TCRαβ+CD4SP and CD3+TCRαβ+CD8SP thymocytes. Negative selection of medullary-type single positive (SP) are more susceptible to apoptosis, while with development of the cells, their resistance to apoptosis increases. Therefore, negative selection does not operate on functionally mature thymocytes at the late stage. This result is a supplement to the traditional theory of negative selection. Negative selection of medullary-type thymocytes is probably to further deplete self-reactive T cells, thus producing precise TCR repertoire and inducing self-tolerance. 关键词：NEGATIVE selection, thymocyte, PHENOTYPIC analysis.

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Negative selection of murine medullary-type single positive thymocytes

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