Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk

查看全文 作　　者：Mansour S Al-[1]Moundhri;Manal Al-[2]Khanbashi;Mohammed Al-[3]Kindi;Maryam Al-[2]Nabhani;Ikram A [1]Burney;Abdulaziz Al-[4]Farsi;Bassim Al-[4]Bahrani 机构地区：[1]Medical Oncology Unit,Department of Medicine,College of Medicine and Health Sciences,Sultan Qaboos University;[2]Department of Clinical Genetics,College of Medicine and Health Sciences,Sultan Qaboos University;[3]Department of Biochemistry,College of Medicine and Health Sciences,Sultan Qaboos University;[4]National Oncology Center,Royal Hospital 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第27期,共5页 摘　　要：AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk predisposition.METHODS:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.RESULTS:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC risk.The haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical significance.CONCLUSION:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman. 关 键 词：Gastric cancer POLYMORPHISM CDH1