Primary site resection is superior for incurable metastatic colorectal cancer

查看全文 作　　者：Yusuke [1]Tanoue;Nobutaka [1]Tanaka;Yukihiro [1]Nomura 机构地区：[1]Department of General Surgery,Asahi General Hospital,I-1326 Asahi,289-2511 Chiba,Japan 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第28期,共6页 摘　　要：AIM:To investigate survival in patients treated with FOLFOX followed by primary site resection or palliative surgery for incurable metastatic colorectal cancer. METHODS:Between 2001 and 2009,a total of 98 patients with colorectal adenocarcinoma and non-resectable metastases were diagnosed and treated with the new systemic agent chemotherapy regimen FOLFOX. Primary site resection was carried out in 38 patients, creation of a colostomy or bypass without resection was carried out in 36 patients,and 23 were not operated on because of advanced disease.The survival times of patients in different groups were analyzed. RESULTS:There were no differences between the patients regarding their general condition,concurrent disease,or tumor stage according to AJCC classification.The median survivals of the three groups were 30.6,20.8,and 12.7 mo(log-rank P value<0.05),respectively.The postoperative complication rate was higher in the primary site resection group than in the palliative surgery group. CONCLUSION:The results indicate that there are benefits from primary site resection for incurable metastatic colorectal cancer with systemic chemotherapy. 关 键 词：Colorectal cancer CHEMOTHERAPY Primary resection Palliative surgery FOLFOX FOLFIRI