Hepatic steatosis,low-grade chronic inflammation and hormone/growth factor/adipokine imbalance

查看全文 作　　者：Giovanni [1]Tarantino;Silvia [2]Savastano;Annamaria [2]Colao 机构地区：[1]Department of Clinical and Experimental Medicine,Federico Ⅱ University Medical School of Naples;[2]Department of Molecular and Clinical Endocrinology and Oncology,Section of Endocrinology,Federico Ⅱ University Medical School of Naples 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第38期,共11页 摘　　要：Non-alcoholic fatty liver disease (NAFLD), a further expression of metabolic syndrome, strictly linked to obesity and diabetes mellitus, is characterized by insulin resistance (IR), elevated serum levels of free fatty acids and fatty infi ltration of the liver, which is known as hepatic steatosis. Hepatocyte apoptosis is a key feature of this disease and correlates with its severity. Free-fatty-acidinduced toxicity represents one of mechanisms for the pathogenesis of NAFLD and hormones, growth factors and adipokines influence also play a key role. This review highlights the various pathways that contribute to the development of hepatic steatosis. Circulating concentrations of inflammatory cytokines are reckoned to be the most important factor in causing and maintaining IR. Low-grade chronic inflammation is fundamental in the progression of NAFLD toward higher risk cirrhotic states. 关 键 词：Hepatic steatosis Low-grade chronic inflammation ADIPOKINES HORMONES Growth factors