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Expressions of Thymidylate Synthase, Thymidine Phosphorylase, Class Ⅲ β-tubulin, and Excision Repair Cross-complementing Group 1 Predict Response in Advanced Gastric Cancer Patients Receiving Capecitabine Plus Paclitaxel or Cisplatin

查看全文 作　　者：Ming [1]Lu;Jing [1]Gao; Xi-cheng [1]Wang; Lin [1]Shen 高影响力作者 机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Gastrointestinal Oncology,Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2011年第23卷第4期,共7页高影响力期刊 基　　金：supported by the National '863' High‐Tech Res & Dev Program of China (No. 2006AA02A402);Beijing Municipal Science & Technology Commission Program 'Optimization of pharmacotherapy and individual selection in gastric cancer' (No D101100050010023) 摘　　要：Objective: To evaluate the role of class III β-tubulin (TUBB3), thymidylate synthase (TS), thymidine phosphorylase (TP), and excision repair cross-complementing group 1 (ERCC1) in clinical outcome of advanced gastric cancer patients receiving capecitabine plus paclitaxel or cisplatin. Methods: The clinical data and tumor specimens from 57 advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel (cohort 1, n=36) and capecitabine plus cisplatin (cohort 2, n=21) were retrospectively collected, and TUBB3, TS, TP, and ERCC1 expressions were detected by real-time quantitative PCR. The associations between expressions of biomarkers and response or survival were analyzed statistically. Results: The median age of 57 patients was 57 years (range: 27-75 years) with 38 males and 19 females. Of all patients, the response rates of patients with high TP, low TP and high TS, low TS expressions were 57.1%, 27.6% (P=0.024), and 55.2%, 28.6% (P=0.042), respectively. Among cohort 1, the response rates and median overall survivals of patients with low and high TUBB3 expressions were 61.1% vs. 33.3% (P=0.095) and 13.8 months vs. 6.6 months (P=0.019), respectively; the response rate (87.5%) of patients with low TUBB3 and high TP expressions was higher than that (14.3%) of patients with high TUBB3 and low TP expressions (P=0.01). Among cohort 2, the response rates of patients with low ERCC1 and high ERCC1 expressions were 45.5% and 20.0% respectively (P=0.361). Conclusion: TUBB3, TS and TP expressions could predict the response of advanced gastric cancer patients receiving capecitabine-based and paclitaxel-based chemotherapy. These results will be further confirmed in future large samples. 关 键 词：Advanced gastric cancer TS/TP/TUBB3/ERCC1 CAPECITABINE PACLITAXEL CISPLATIN
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