Components in Antineoplastic Actinomycete Strain (N2010-37) of Bottom Mud in Mangrove

查看全文 作　　者：ZHOU Zhong-liu1,2,JIN Bei1,YIN Wen-qing2,FU Chun-yan2,FENG Hua-fen2 1.Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang 524048,China 2.Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education,School of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin 541004,China

出　　处：《Chinese Herbal Medicines》索引2011年第3卷第3期,共3页

基　　金：Foundation for Distinguished Young Talents in Higher Education of Guangdong,China (LYM09100) 摘　　要：Objective To study the antitumor components from an actinomycete strain(N2010-37) of bottom mud in Zhanjiang Mangrove,South China Sea.Methods The components were isolated and purified by chromatographic techniques and recrystallization,and the structures were identified by spectral methods together with physicochemical analyses.The antitumor effects of these components were tested in vitro by MTT method.Results Three compounds were identified including two anthrones and one novel lactone.They are(3S,4R,7R,8R,9S)-3,8-dihydroxy-4,7,9-trimethyl-2,6-cyclononanediolacetone(1) ,2-hydroxy-1-methoxy-3-methylanthraquinone(2) ,and 1,6,8-thihydroxy-3-methylanthraquinone(3) .Conclusion Compound 1 is a new compound,and compounds 1 and 3 show the favorable cytotoxic activities against human chronic granulocytic leukemia cell line K562 strain by MTT method in vitro. 关键词：ACTINOMYCETE ANTIMYCIN antitumor activities MANGROVE novel lactone

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Components in Antineoplastic Actinomycete Strain (N2010-37) of Bottom Mud in Mangrove

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