Lubiprostone used with polyethylene glycol in diabetic patients enhances colonoscopy preparation quality

查看全文 作　　者：Erika [1]Grigg;Moonkyung C [1]Schubert;Joshua [1]Hall;Fadi [1]Rahhal;Dimple [1]Raina;Subbaramiah [1]Sridhar;Sherman M [1]Chamberlain

机构地区：[1]Section of Gastroenterology and Hepatology,Medical College of Georgia,Augusta,GA 30912,United States

出　　处：《World Journal of Gastrointestinal Endoscopy》索引2010年第2卷第7期,共5页

基　　金：Supported by Sucampo Pharmaceuticals,Inc.,Bethesda,Maryland and Takeda PharmaceuticalsAmerica,Inc.,Deerfield,Illinois 摘　　要：AIM: To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte(PEG)for colonoscopy.METHODS:This was an investigator-initiated,singlecenter,single-blinded prospective trial comparing the efficacy of L+PEG to PEG alone on colon preparation quality in diabetics undergoing screening colonoscopy.The study was approved by our institution’s IRB.The PEG was given as a single-dose to address patientcompliance concerns voiced by our IRB with splitdosing.All patients received only clear liquids the day prior to colonoscopy.Experimental group(Grp L)received PEG+1 dose L 2 h prior to and 2 h after PEG completion.Control group(Grp C)received only PEG the evening prior to the colonoscopy.Patients were randomly assigned to one of the 2 groups.The endoscopist was blinded to which colon prep was given and all colonoscopies were complete.Upon colonoscopy completion,the endoscopist rated the colon prep-quality by a validated 5-point Likert scale(1-excellent to 5-inadequate).RESULTS:Sixty patients were enrolled in the study;30 Grp L and 30 Grp C.Overall,patients were excluded due to study non-completion in 12(41%)Grp L and 5(17%) Grp C,P=0.04.Average colon preparation score Grp L =2.47 and Grp C=3.00,P=0.09.Although this was not statistically significant,there was a trend towards improved colon prep in Grp L.Statistical significance may have been achieved if completion rates had been similar between both study groups.CONCLUSION:Use of 2-L capsules with PEG resulted in a trend towards improved colon prep over PEG alone in diabetic patients when given as a single-dose regimen. 关键词：LUBIPROSTONE POLYETHYLENE GLYCOL Diabetes COLONOSCOPY COLON PREPARATION

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Lubiprostone used with polyethylene glycol in diabetic patients enhances colonoscopy preparation quality

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