Pathological aspects of so called 'hilar cholangiocarcinoma'

查看全文 作　　者：Víctor M Castellano-[1]Megías;Carolina Ibarrola-de [2]Andrés;Francisco Colina-[2]Ruizdelgado

机构地区：[1]Department of Pathology,Hospital Universitario de Fuenlabrada,28041 Madrid,Spain.;[2]Department of Pathology,Hospital Universitario '12 de Octubre',28041 Madrid,Spain.

出　　处：《World Journal of Gastrointestinal Oncology》索引2013年第5卷第7期,共12页

摘　　要：Cholangiocarcinoma(CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group.However,'hilar and perihilar CC' are also used to refer exclusively to the intrahepatic hilar type CC or,more commonly,the extrahepatic hilar CC.Grossly,a major distinction can be made between papillary and non-papillary tumors.Histologically,most hilar CCs are well to moderately differentiated conventional type(biliary) carcinomas.Immunohistochemically,CK7,CK20,CEA and MUC1 are normally expressed,being MUC2 positive in less than 50% of cases.Two main premalignant lesions are known:biliary intraepithelial neoplasia(BilIN) and intraductal papillary neoplasm of the biliary tract(IPNB).IPNB includes the lesions previously named biliary papillomatosis and papillary carcinoma.A series of 29 resected hilar CC from our archives is reviewed.Most(82.8%) were conventional type adenocarcinomas,mostly well to moderately differentiated,although with a broad morphological spectrum;three cases exhibited a poorly differentiated cell component resembling signet ring cells.IPNB was observed in 5(17.2%),four of them with an associated invasive carcinoma.A clear cell type carcinoma,an adenosquamous carcinoma and two gastric foveolar type carcinomas were observed. 关键词：CHOLANGIOCARCINOMA BILE DUCT CARCINOMA HILAR CHOLANGIOCARCINOMA Perihilar CHOLANGIOCARCINOMA Klatskin tumor EXTRAHEPATIC BILE DUCT CARCINOMA Hepatic hilum

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Pathological aspects of so called 'hilar cholangiocarcinoma'

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