Role of sex hormones in the modulation of cholangiocyte function

查看全文 作　　者：Romina [1]Mancinelli;Paolo [2]Onori;Sharon [3]DeMorrow;Heather [3]Francis;Shannon [3]Glaser;Antonio [1]Franchitto;Guido [4]Carpino;Gianfranco [5,3]Alpini;Eugenio [1]Gaudio

机构地区：[1]Department of Human Anatomy,University of Rome 'La Sapienza';[2]Department of Experimental Medicine,University of L'Aquila;[3]Scott and White Digestive Disease Research Center,Texas A&M Health Science Center,College of Medicine;[4]Department of Health Science,University of Rome 'Foro Italico',Rome 00135,Italy;[5]Research,Central Texas Veterans Health Care System

出　　处：《World Journal of Gastrointestinal Pathophysiology》索引2010年第1卷第2期,共13页

基　　金：Supported partly by the University Federate Athenaeum Funds from University of Rome 'La Sapienza' and PRIN 2007 to Gaudio E;University Funds to Onori P,the Dr.Nicholas C Hightower Centennial Chair of Gastroenterology from Scott and White;the VA Research Scholar Award;a VA Merit Awardand the NIH Grants DK58411,and DK76898 to Dr.Alpini;a NIH RO1 Grant Award to Dr.Glaser(DK081442);a NIH K01Grant Award(DK078532)to Dr.DeMorrow 摘　　要：Over the last years,cholangiocytes,the cells that line the biliary tree,have been considered an important object of study for their biological properties which involves bile formation,proliferation,injury repair,fibrosis and angiogenesis.Cholangiocyte proliferation occurs in all pathologic conditions of liver injury where it is associated with inflammation and regeneration.During these processes,biliary cells start to secrete different cytokines,growth factors,neuropeptides and hormones which represent potential mechanisms for cross talk with other liver cells.Several studies suggest that hormones,and in particular,sex hormones,play a fundamental role in the modulation of the growth of this compartment in the injured liver which functionally conditions the progression of liver disease.Understanding the mechanisms of action and the intracellular pathways of these compounds on cholangiocyte pathophysiology will provide new potential strategies for the management of chronic liver diseases.The purpose of this review is to summarize the recent findings on the role of sex hormones in cholangiocyte proliferation and biology. 关键词：BILIARY EPITHELIUM SEX HORMONES Cholestatic DISEASES

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Role of sex hormones in the modulation of cholangiocyte function

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