MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease

查看全文 作　　者：Rebecca [1]Mitchell;Jill [2]McDermid;Mang M [2]Ma;Constance L [1]Chik

机构地区：[1]Divisions of Endocrinology and Metabolism,Department of Medicine,Faculty of Medicine and Dentistry,University of Alberta,Edmonton,AB T6G 2S2,Alberta,Canada;[2]Division of Gastroenterology,Department of Medicine,Faculty of Medicine and Dentistry,University of Alberta,Edmonton,AB T6G 2S2,Alberta,Canada

出　　处：《World Journal of Hepatology》索引2011年第3卷第6期,共7页

基　　金：Supported by the Transplant Program of the University of Alberta Hospital 摘　　要：AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. 关键词：Hepatic OSTEODYSTROPHY INSULIN-LIKE growth factor-1 CYTOKINES Bone mineral density MELD SCORE

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MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease

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