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Noninvasive predictors for liver fibrosis in patients with nonalcoholic steatohepatitis

查看全文 作　　者：Hüseyin Saadettin [1]Uslusoy;Selim Giray [1]Nak;Macit [1]Gülten 高影响力作者 机构地区：[1]Department of Gastrenterology,zmit Seka State Hospital高影响力机构 出　　处：《World Journal of Hepatology》索引2011年第3卷第8期,共9页高影响力期刊 基　　金：Supported by The Uludag University Scientific Project Grant 摘　　要：AIM:To evaluate certain anthropometric,clinical and laboratory features indicating liver fibrosis in nonalcoholic steatohepatitis and to establish the noninvasive markers for liver fibrosis.METHODS:Eighty-one patients (40 male,41 female) who were diagnosed with fatty liver by ultrasonographic examination and fulfilled the inclusion criteria participated in the study.Anamnesis,anthropometric,clinical and laboratory features of all cases were recorded and then liver biopsy was performed after obtaining patient consent.Steatosis,necroinflammation and liver fibrosis were examined according to age ≥ 45,gender,body mass index,central obesity,aspartate amino-transferase (AST)/alanine aminotransferase (ALT)>1,γ-glutamyltransferase (GGT)/ALT>1,platelet count,insulin,c-peptide levels and the presence of hypertension,diabetes,hypertriglyceridemia and insulin resis-tance.RESULTS:Eighty-one patients with non-alcoholic steatohepatitis (NASH) enrolled in the study.69 of 81 patients were diagnosed with NASH,11 were diagnosed with simple fatty liver and 1 was diagnosed with cirrhosis.AST/ALT>1,GGT/ALT>11,high serum ferritin and fasting insulin levels,the presence of diabetes,hypertension,hypertriglyceridemia and insulin resistance seemed to enhance the severity of steatosis,necroinflammation and fibrosis but these results were not statistically significant.CONCLUSION:Liver steatosis and fibrosis can occur in individuals with normal weight.There was no significant concordance between severity of liver histology and the presence of predictors for liver fibrosis including metabolic risk factors. 关 键 词：LIVER fibrosis PREDICTORS NONALCOHOLIC fatty LIVER disease STEATOHEPATITIS
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