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Image of tumor metastasis and inflammatory lymph node enlargement by contrast-enhanced ultrasonography

查看全文 作　　者：Takaya [1]Aoki;Fuminori [1]Moriyasu;Kei [1]Yamamoto;Masafumi [1]Shimizu;Masahiko [1]Yamada;Yasuharu [1]Imai 高影响力作者 机构地区：[1]Department of Gastroenterology and Hepatology,Tokyo Medical University, 6-7-1,Nishishinjuku,Shinjyuku-ku,Tokyo 160-0023,Japan高影响力机构 出　　处：《World Journal of Radiology》索引2011年第3卷第12期,共8页高影响力期刊 摘　　要：AIM:To compare the difference between tumorinduced lymph node enlargement and inflammation-induced lymph node enlargement by contrast-enhanced ultrasonography and pathological findings. METHODS:A model of tumor-induced lymph node metastasis was prepared by embedding a VX2 tumor into the hind paws of white rabbits.A model of inflammation-induced enlargement was prepared by injecting a suspension of Escherichia coli into separate hind paws of white rabbits.Then,a solution of SonazoidTM(GE Healthcare,Oslo,Norway)was injected subcutaneously in the proximity of the lesion followed by contrast-enhanced ultrasonography of the enlarged popliteal lymph nodes. RESULTS:In the contrast-enhanced ultrasonography of the tumor-induced metastasis model,the sentinel lymph node was imaged.An area of filling defect was observed in that enlarged lymph node.In the histology examination,the area of filling defect corresponded to the metastatic lesion of the tumor.Contrast-enhanced ultrasonography of the model on inflammation-induced lymph node enlargement,and that of the acute inflam-mation model performed 3-7 d later,revealed dense staining that was comparatively uniform.The pathological findings showed acute lymphadenitis mainly due to infiltration of inflammatory cells.Contrast-enhanced ultrasonography that was performed 28 d post-infection in the acute inflammation model showed speckled staining.Inflammation-induced cell infiltration and fiberization,which are findings of chronic lymphadenitis, were seen in the pathological findings. CONCLUSION:Sentinel lymph node imaging was made possible by subcutaneous injection of SonazoidTM.Contrast-enhanced ultrasonography was suggested to be useful in differentiating tumor-induced enlargement and inflammation-induced enlargement of lymph nodes. 关 键 词：Lymph node enlargement Sentinel lymph node Contrast-enhanced ultrasonography Subcutaneous injection Sonazoid^(TM)
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