Ibutilide and novel indexes of ventricular repolarization in persistent atrial fibrillation patients

查看全文 作　　者：Panagiotis [1]Korantzopoulos;Konstantinos P [1,2]Letsas;Anna [1]Kotsia;Giannis [1]Baltogiannis;Kallirroi [1]Kalantzi;Konstantinos [1]Kyrlas;John A [1]Goudevenos

机构地区：[1]Department of Cardiology, University of Ioannina Medical School,45110 Ioannina,Greece;[2]Second Department of Cardiology,Evangelismos General Hospital of Athens,10675 Athens,Greece

出　　处：《World Journal of Cardiology》索引2013年第5卷第7期,共5页

摘　　要：AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1+1mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as corrected QT interval (QTc), the interval from the peak until the end of T wave (Tpe), and the Tpe/QT ratio were measured before ibutilide infusion and 10 min after the end of infusion. RESULTS: The final study population consisted of 20 patients (mean age: 67.1±9.9 years, 10 men). Six patients were cardioverted pharmacologically and did not proceed to electrical cardioversion. Two patientsdeveloped short non-sustained episodes of torsades de pointes ventricular tachycardia. All but one of the aforementioned ECG indexes increased significantly after ibutilide administration. In specific, the QTc interval increased from 442 ± 29 to 471 ± 37 ms (P=0.037), the Tpe interval in precordial leads from 96 ms (range 80-108 ms) to 101 ms (range 91-119 ms) (P=0.021), the Tpe interval in lead Ⅱ from 79 ms (range 70-88 ms) to 100 ms (range 87-104 ms) (P<0.001), the Tpe/QT ratio in precordial leads from 0.23 ms (range 0.18-0.26 ms) to 0.26 ms (range 0.23-0.28 ms) (P=0.028), and the Tpe interval dispersion from 25 ms (range 23-30 ms) to 35 ms (range 27-39 ms) (P=0.012). However, the Tpe/QT ratio in lead II did not change significantly. CONCLUSION: Ibutilide increases the duration and dispersion of ventricular repolarization. The prognostic value of Tpe and Tpe/QT in the setting of drug-induced proarrhythmia needs further study. 关键词：IBUTILIDE VENTRICULAR REPOLARIZATION Arrhythmic risk PROARRHYTHMIA Dispersion of REPOLARIZATION T peak-to-end T peak-to-end/QT ratio

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Ibutilide and novel indexes of ventricular repolarization in persistent atrial fibrillation patients

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