Clinical significance of mrp gene in primary hepatocellular carcinoma

查看全文 作　　者：Bai-Lin Wang;Xiao-Ping Chen;Shu-Ping Zhai;De-Feng Chen the 3rd Department of Surgery, First Affiliated Hospital of Guangzhou University of Traditional Medicine and Pharmacy, Guangzhou 510405, China the Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2003年第2卷第3期,共7页

摘　　要：OBJECTIVE: To study the relations among the expression of the multidrug resistanceassociated-protein (mrp) gene and clinicopathologic features, the influence of α-fetoprotein (AFP),and prognosis of patients who received adjuvant chemotherapy after resection of primary hepatocellularcarcinoma (HCC).METHODS: The expression of the mrp gene encoding MRP and mRNAmrp was determined in tissuesfrom 54 untreated patients with HCC, adjacent tissues from 24 patients with HCC and archivalparaffin-embedded tissues from 12 patients with posthepatitic cirrhosis. The relationship between the mrpgene expression and the change level of AFP was analyzed in the 24 postoperative HCC patients whoseAFP level was measured after 2 weeks. All of the HCC patients were followed up.RESULTS: The percentage of positive expressions of MRP and mRNAmrp in the three kinds of tissueswas 57.40%, 25.00%, 16.67%, and 72.22%, 37.50%, 33.33% respectively. Significant difference wasnoted in the untreated HCC tissue, compared to the other two tissues (P<0.05). No difference existedbetween the mrp gene expression and such clinicopathologic findings, as age, sex, and tumor size (P>0.05), but the expression was related to the degree of differentiation of HCC (P<0.05). The effectiverate of AFP in the mrp gene positive expression group or postoperative chemotherapeutic patients was lowerthan that in the negative group (P<0.05). Although no difference was seen in the 1-, 3-, 5-year survivalrates of HCC patients (P>0.05), the mean survival time of postoperative HCC patients or the negativemrp gene expression group was longer than that of the positive group (P<0.05).CONCLUSIONS: Multidrug resistance (MDR) of HCC is related to mrp gene expression and initiatesthe intrinsic MDR. Detection of mrp gene expression is of great significance in accessing chemotherapeuticresistance of HCC, which provides evidence for reversing MDR in HCC. The mrp gene may be a usefulmarker in detecting prognosis of HCC patients because its expression is correlated with tumor differentionand mean survival time of the patients. 关键词：HEPATOCELLULAR CARCINOMA GENE MRP MRP MRP RNV/messenger

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Clinical significance of mrp gene in primary hepatocellular carcinoma

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