Protective effect of Sida cordata leaf extract against CCl_4 induced acute liver toxicity in rats

查看全文 作　　者：Sunil [1]Mistry;KR [2]Dutt;J [3]Jena

机构地区：[1]Gayatri College of Pharmacy,Gayatri Vihar,Sambalpur,Orissa-768200,India;[2]CMR College of Pharmacy,Kandlakoya,Medchan Road,Hyderabad-501401,India;[3]Department of Pharmacology,VSS Medical College,Sambalpur University

出　　处：《Asian Pacific Journal of Tropical Medicine》索引2013年第6卷第4期,共5页

摘　　要：Objective:To investigate the hepatoprotective potential of Sida cordata(Malvaceae)(S.cordata) in experimental rats to validate its traditional claim.Methods:Wister albino rats were divided into 6 groups:Croup 1 served as control;CroupⅡserved as hepatotoxic(CCl₄ treated) group; CroupⅢ,Ⅳand V served as(100,200 and 400 mg/kg b.w.) S.cordata leaf extract(SCLE) treated groups;CroupⅥserved as positive control(Silymarin) treated group.Liver marker enzymes serum glutamate oxyloacetic transaminase,serum glutamic pyruvic transaminase,pancreatic enzymatic antioxidants superoxide dismutase(SOD),lipid peroxidation,catalase(CAT),reduced glutathione(CSH) were measured and compared along with histopathological studies.Results: Obtained results show that the treatment with SCI.E significantly(P<0.05-<0.001) and dosedependently reduced CCl₄ induced elevated serum level of hepatic enzymes.Furthermore, SCLE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes CSH,SOD and CAT towards normal levels,which was confirmed by the histopathological studies.Conclusions:The results of this study strongly indicate the protective effect of SCLE against CCl₄ induced acute liver toxicity in rats and thereby scientifically support its traditional use. 关键词：SIDA cordata HISTOPATHOLOGY HEPATOPROTECTIVE CCl₄

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Protective effect of Sida cordata leaf extract against CCl_4 induced acute liver toxicity in rats

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