TGF-β1 signal pathway in the regulation of inflammation in patients with atrial fibrillation

查看全文 作　　者：Ye Erbo lati.Ali [1]Mira;[1]Muhuyati;Wu-Hong [2]Lu;Peng-Yi [1]He;Zhi-Qiang [1]Liu;Yu-Chun [1]Yang

机构地区：[1]Comprehensive Cardiology Department,First Affiliated Hospital of Xinjiang Medical University;[2]Cardiac Institute,First Affiliated Hospital of Xinjiang Medical University

出　　处：《Asian Pacific Journal of Tropical Medicine》索引2013年第6卷第12期,共5页

基　　金：supported by National Science Funded Project(81060017) 摘　　要：Objective:To observe the expression changes of inflammatory markers TGF-β1,Smad3 and IL-6 in patients with atrial fibrillation(AF),and to explore the significance of TGF-β1 signaling pathway in the structural remodeling of AF.Methods:The expression of TGF-β1,Smad3 and IL-6 in 50 cases with AF and 30 normal cases were detected by RT-PCR and ELISA.Results:The TGF-β1,Smad3 and IL-6 mRNA and protein expression levels in patients with AF were significantly higher than that in the control group(P<0.05),but there was no significantly different between the paroxysmal AF group and the persistent AF group(P>0.05).The TGF-β1mRNA expression in the≥50 years subgroup was significantly higher than that in the<50years subgroups,and it was higher in the NYHAⅢsubgroup than in theⅠ/Ⅱgrade subgroup.It was also higher in the left ventricular ejection fraction(LVEF)<50%subgroup than in LVEF≥50%group,and it was significantly higher in the AF time≥36 months subgroup than that in<36months subgroup(P<0.05).The Smad3 and IL-6 expressions in the in the LVEF<50%subgroup were both high that than that in LVEF≥50%group,and higher in the AF time≥36 months subgroup than that in<36 months subgroup(P<0.05).There were a positive correlation between TGF-β1,Smad3 and IL-6(r=0.687,r=0.547).There were also a positive correlation between Smad3 and IL-6 mRNA(r=0.823).Conclusions:AF is associated with inflammation,and the inflammation is also involved in the fibrillation and sustain of AF.The TGF-β1 signal pathway may be involved in the process of atrial structural remodeling in patients with AF,and iss related with the occurrence and maintenance of AF. 关键词：ATRIAL FIBRILLATION TRANSFORMING growth factor β1 Signal TRANSDUCTION INFLAMMATION

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TGF-β1 signal pathway in the regulation of inflammation in patients with atrial fibrillation

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