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Effect Comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse

查看全文 作　　者：Suchun [1]Yan;Yiqiang [2]Xie;Bide [3]Zhu;Yingguang [4]Han;Wei [4]Guo 高影响力作者 机构地区：[1]General Hospital of Tianjin Medical University;[2]Hainan Medical College;[3]Chengdu University of TCM;[4]Sanjiu Modern Medicine Ltd高影响力机构 出　　处：《Asian Pacific Journal of Tropical Medicine》索引2011年第4卷第7期,共4页高影响力期刊 基　　金：the Sanjiu Modern Medicine Ltd.for providing fund and DGBXT granule formula 摘　　要：Objective:To compare effect of different formulation of Dang-Gui-Bu-Xu-Tang(DCBXT) on myelosuppression mouse.Methods:HPLC was used to measure active ingredients of two DGBXT formulations,Hemopoesic function of bone marrow was measured by hemopoietic progenitor cell culture and peipheral blood count.And hemopoietic factors in bone marrow were tested by ELISA.Results:The content level of astragaloside A in granule formulation was higher than that in decoction and the content ratio of active ingredient was close to 5:1.Two DGBXD formulations could significantly improve amount of peripheral blood cells,and bone marrow cells of bone marrow suppression mice(P<0.05).DGBXD granule formulation significantly increased the colony quantity of all progenitor cell lines and amount of G2/M and S phase cells(P<0.05). It also significantly decreased amount of G0/G1 phase cells in the bone marrow and was more effective(P<0.05).Conclusions:DGBXT decoction and the granule formulation all can improve the hematopoietic function of bone marrow suppression mouse.They can improve quantities of peripheral blood and nucleated bone marrow cells,and yield of the hematopoietic stem/progenitor cells in vitro colony;balance the expression of cytokine(EPO,TPO and GM-GSF) in bone marrow microenvirement.They can also facilitate hematopoietic stem/progenitor cells to enter the cell cycle.And the effect of granule formulation is more satisfactory. 关 键 词：DGBXT GRANULE FORMULATION Mvelosuppression HEMATOPOIETIC regulation HCMV
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