A study of in vitro antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand

查看全文 作　　者：Waleed Mahmoud Al [1]Momani;Ziyad Ahmed [2]Taha;Abdulaziz Mahmoud [2]Ajlouni;Qasem Mohammad Abu [3]Shaqra;Muaz Al [1]Zouby

机构地区：[1]Department of Allied Medical Sciences,Al Balqa' Applied University;[2]Department of Applied Chemical Sciences,Jordan University of Science and Technology;[3]Medical Diagnostic Laboratories

出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2013年第3卷第5期,共4页

基　　金：Supported by dean of research/JUST(Grant No.48/2008) 摘　　要：Objective:To establish the antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand L.Methods:(N,N'-bis(l-naphthaldimine)-o-phenylenediamine)was prepared from the condensation of 2—hydroxy-1-naphthaldehyde with o-phenylenediamine in a molar ratio of 2:1.The antimicrobial activity of the resultant Ln(Ⅲ)complexes was investigated using agar well diffusion and micro-broth dilution techniques;the latter was used to establish the minimum inhibitory concentrations for each compound investigated.Results:Most of Ln(Ⅲ)complexes were found to exhibit antibacterial activities against a number of pathogenic bacteria with MICs ranging between 1.95-250.00μg/mL.Staphylococcus aureus was the most susceptible bacterial species to[LaL(NO_3)_2(H_2O)](NO_3)complex while Shigella dysenteriae and Escherichia coli required a relatively higher MIC(250μg/mL).Trie complexes La(Ⅲ)and Pr(Ⅲ)were effective inhibitors against Staphylococcus aureus,whereas Sm(Ⅲ)complex was effective against Serratia marcescens.On the other hand,Gd(Ⅲ),La(Ⅲ)and Nd(Ⅲ)were found to be more potent inhibitors against Pseudompnas aeruginosa than two of commonly used antibiotics.The remaining Ln(Ⅲ)complexes showed no remarkable activity as compared to the two standard drugs used.Conclusions:Tetradentate Schiff base ligand L and its complexes could be a potential antibacterial compounds after further investigation. 关键词：ANTIMICROBIAL Biomolecules ORGANICS Synthetic LIGANDS

相关文献

参考文献（16）
引证文献（3）
耦合文献（1）

参考文献(16)

引证文献(3)

耦合文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

A study of in vitro antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand

参考文献(16)

引证文献(3)

耦合文献(1)

用户提示