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Macular atrophy after combined intravitreal triamcinolone and photodynamic therapy to treat choroidal neovascularization

查看全文 作　　者：Jose M Ruiz-[1,2]Moreno;Javier A [2,3]Montero;Pedro [2]Amat;Francisco [2]Lugo 高影响力作者 机构地区：[1]Department of Ophthalmology,Albacete Medical School,University of Castilla La Mancha,Spain;[2]Alicante Institute of Ophthalmology,Vitreo-Retinal Unit.Spain;[3]Pio del Rio Hortega University Hospital,Ophthalmology Unit,Valladolid,Spain高影响力机构 出　　处：《International Journal of Ophthalmology(English edition)》索引2010年第3卷第2期,共3页高影响力期刊 摘　　要：AIM:To report the appearance of choriocapillaris atrophy after combined high dose intravitreal triamcinolone acetonide (TA)and photodynamic therapy(PDT)to treat choroidal neovascularization(CNV)associated with age related macular degeneration(AMD). METHODS:The present study was retrospective about non-randomized interventional case series.Fifty-one consecutive eyes with subfoveal(all types)CNV associated with AMD were treated by PDT and intravitreal(19.4±2.1)mg per O.1mL TA at the Alicante Institute of Ophthalmology.The appearance of macular choriocapillaris and retinal pigment epithelium(RPE)atrophy was considered at two years follow-up.Thirty consecutive eyes treated by PDT alone, matched for age,sex,and type and size of CNV were considered as control group. RESULTS:Twenty-one of 47 eyes in the study group(45%) and 7 of 30 eyes in the control group(23%)developed macular RPE and choriocapillaris atrophy in the treated area at month 24(P=0.04,Chi-square test).The greatest diameter of the atrophic areas averaged(5044±1666)μm in the study group vs(4345±1550)μm in the control group. Mean final best corrected visual acuity(logarithm of minimal angle of resolution)was(0.87±0.33)in the cases with RPE atrophy vs(0.66±0.26)in the cases with no RPE atrophy in the study group(P=0.11,Mann-Whitney U test). CONCLUSION:The association of high doses of intravitreal TA and PDT may increase the risk for RPE and choriocapillaris atrophy. 关 键 词：age related MACULAR degeneration CHORIOCAPILLARIS ATROPHY intravitreous TRIAMCINOLONE photodynamic therapy retinal PIGMENT EPITHELIUM ATROPHY
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