The role of MC1R gene in buffalo coat color

查看全文 作　　者：MIAO YongWang1,2,WU GuiSheng3,WANG Lei2,LI DaLin4,TANG ShouKun5,LIANG JianPing2,MAO HuaMing2,LUO HuaiRong3 & ZHANG YaPing1,6 1 Laboratory for Conservation and Utilization of Bio-resource,Yunnan University,Kunming 650091,China;2 Faculty of Animal Science and Technology,Yunnan Agricultural University,Kunming 650201,China;3 Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China;4 Yunnan Institute of Buffalo Science and Technology,Kunming 650021,China;5 Animal Husbandry and Veterinary Station of Luxi city,Luxi 678400,China;6 State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China

出　　处：《Science China(Life Sciences)》索引2010年第53卷第2期,共6页

基　　金：supported by the National Natural Science Foundation of China (Grant Nos. 30660024 and 30621092);the National Major Projects for Transgenic organisms (Grant No. 2008ZX08009);Natural Science Foundation of Yunnan Province, China (Grant Nos. 2007C0003Z and 2006C0034M) ;the National Hi-New Technology Research and Devel-opment Plan of China (Grant No. 2008AA101001) 摘　　要：Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species.To investigate if the MC1R gene is associated with coat color in water buffalo,the coding region of MC1R gene of 216 buffalo samples was sequenced,which included 49 black river buffalo (Murrah and Nili-Ravi),136 swamp buffalo (Dehong,Diandongnan,Dechang,Guizhou,and Xilin) with white and gray body,and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp buffalo.Among the three variation sites found,SNP684 was synonymous,while SNP310 and SNP384 were nonsynonymous,leading to p.S104G and p.I128M changes,respectively.Only Individuals carrying homozygote EBR/EBR were black.The genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele EBR or the allele carrying the amino acid p.104S was important for the full function of MC1R.The in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of MC1R.Above results indicate that the allele EBR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo. 关键词：BUFFALO COAT COLOR MC1R

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The role of MC1R gene in buffalo coat color

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