Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients

查看全文 作　　者：Sylvia [1]Brost;Paul [2]Schnitzler;Wolfgang [1]Stremmel;Christoph [1]Eisenbach

机构地区：[1]Department of Gastroenterology and Infectious Diseases, University of Heidelberg;[2]Department of Infectious Diseases, Virology, University of Heidelberg

出　　处：《World Journal of Gastroenterology》索引2010年第16卷第43期,共5页

摘　　要：AIM: To study the efficacy and safety of entecavir (ETV) as first-line therapy for hepatitis B virus (HBV) reactivation due to immunosuppression. METHODS: Four patients that were treated with different immunosuppressive regimens for hematological malignancies, who presented with HBV reactivation were treated with ETV. Clinical outcome, biochemical and virological factors, including quantitative hepatitis B surface antigen (HBsAg) were studied. RESULTS: In all patients, ETV induced suppression of HBV, and rapid clinical improvement without side effects. In one patient with an alanine aminotransferase (ALT) flare, tenofovir was added after 3 mo of treatment. Until death from disease progression at 6 mo after treatment initiation, this patient did not clear HBV infection. Retrospectively, it is highly probable that thepatient had been non-adherent. In the other three patients, the virological responses were associated with an expeditious decrease in quantitative HBsAg titers with negativity after 2 mo, and all three had HBsAg seroconversion. In one patient, HBV DNA reached a plateau after 3 mo, before becoming undetectable after 1 year, despite early ALT normalization and undetectable quantitative HBsAg. CONCLUSION: ETV seems to be effective and safe treatment for HBV reactivation. Monitoring of quantitative HBsAg might be an additional useful tool to monitor treatment response. 关键词：HEPATITIS B virus ENTECAVIR IMMUNOSUPPRESSION HEPATITIS B surface antigen SEROCONVERSION

相关文献

参考文献（20）
引证文献（7）
耦合文献（15）

参考文献(20)

引证文献(7)

耦合文献(15)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients

参考文献(20)

引证文献(7)

耦合文献(15)

用户提示