Role of nitric oxide in hepatic ischemia-reperfusion injury

查看全文 作　　者：Arunotai [1]Siriussawakul;Ahmed [1]Zaky;John D [1]Lang

机构地区：[1]Department of Anesthesiology and Pain Medicine and the VA Puget Sound Healthcare System,the University of Washington School of Medicine

出　　处：《World Journal of Gastroenterology》索引2010年第16卷第48期,共8页

摘　　要：Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress,cytokine release,leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI,role of inhaled NO in ameliorating IRI,modes of delivery,donor drugs and potential side effects of exogenous NO. 关键词：NITRIC OXIDE Liver ISCHEMIA-REPERFUSION INJURY DRUG delivery

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Role of nitric oxide in hepatic ischemia-reperfusion injury

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