Pleiotrophin promotes perineural invasion in pancreatic cancer

查看全文 作　　者：Jun [1]Yao;Xiu-Feng [1]Hu;Xiao-Shan [1]Feng;She-Gan [1]Gao

机构地区：[1]Department of Oncology,the First Affiliated Hospital of Henan University of Science and Technology

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第39期,共4页

基　　金：Supported by National Natural Science Foundation of China,No.U1204819;Health Science and Technology Innovation Talents Program of Henan Province,China,No.4203 摘　　要：Perineural invasion(PNI)in pancreatic cancer is an important cause of local recurrence,but little is known about its mechanism.Pleiotrophin(PTN)is an important neurotrophic factor.It is of interest that our recent experimental data showed its involvement in PNI of pancreatic cancer.PTN strongly presents in the cytoplasm of pancreatic cancer cells,and high expression of PTN and its receptor may contribute to the high PNI of pancreatic cancer.Correspondingly,PNI is prone to happen in PTN-positive tumors.We thus hypothesize that,as a neurite growth-promoting factor,PTN may promote PNI in pancreatic cancer.PTN is released at the time of tumor cell necrosis,and binds with its highaffinity receptor,N-syndecan on pancreatic nerves,to promote neural growth in pancreatic cancer.Furthermore,neural destruction leads to a distorted neural homeostasis.Neurons and Schwann cells produce more N-syndecan in an effort to repair the pancreatic nerves.However,the abundance of N-syndecan attracts further PTN-positive cancer cells to the site of injury,creating a vicious cycle.Ultimately,increased PTN and N-syndecan levels,due to the continuous nerve injury,may promote cancer invasion and propagation along the neural structures.Therefore,it is meaningful to discuss the relationship between PTN/N-syndecan signaling and PNI in pancreatic cancer,which may lead to a better understanding of the mechanism of PNI in pancreatic cancer. 关键词：PLEIOTROPHIN N-syndecan NEURITE OUTGROWTH Perineural invasion PANCREATIC cancer

相关文献

参考文献（38）
引证文献（12）
耦合文献（7）

参考文献(38)

引证文献(12)

耦合文献(7)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Pleiotrophin promotes perineural invasion in pancreatic cancer

参考文献(38)

引证文献(12)

耦合文献(7)

用户提示