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Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer

查看全文 作　　者：Zhen-Jun [1,2]Li;Xiao-Jiang [1,2]Ying;Hong-Liang [1,2]Chen;Ping-Jiang [1,2]Ye;Zhi-Liang [1,2]Chen;Gang [1,2]Li;Hua-Feng [1,2]Jiang;Jiang [1,2]Liu;Shu-Zhen [1,2]Zhou 高影响力作者 机构地区：[1]Department of Colorectal Surgery,Shaoxing People’s Hospital;[2]Shaoxing Hospital of Zhejiang University高影响力机构 出　　处：《World Journal of Gastroenterology》索引2013年第19卷第43期,共7页高影响力期刊 基　　金：Supported by Technological Research Project for Public Welfare from Science and Technology Department of Zhejiang Province,No.2010C33099 摘　　要：AIM:To investigate the expression of insulin-like growth factor-1(IGF-1)/insulin-like growth factor-1 receptor(IGF-1R)in colorectal cancer(CRC)tissues and to analyze their correlation with lymphangiogenesis and lymphatic metastasis.METHODS:Immunohistochemistry was used to evaluate IGF-1 and IGF-1R expression and lymphatic vessel density(LVD)in 40 CRC specimens.The correlation between IGF-1/IGF-1R and LVD was investigated.Effects of IGF-1 on migration and invasion of CRC cells were examined using transwell chamber assays.A LoVo cell xenograft model was established to further detect the role of IGF-1 in CRC lymphangiogenesis in vivo. RESULTS:Elevated IGF-1 and IGF-1R expression in CRC tissues was correlated with lymph node metastasis(r=0.715 and 0.569,respectively,P<0.05)and tumor TNM stage(r=0.731 and 0.609,P<0.05).A higher LVD was also found in CRC tissues and was correlated with lymphatic metastasis(r=0.405,P<0.05).A positive correlation was found between LVD and IGF-1R expression(r=0.437,P<0.05).Transwell assays revealed that IGF-1 increased the migration and invasion of CRC cells.In vivo mouse studies showed that IGF-1 also increased LVD in LoVo cell xenografts.CONCLUSION:IGF-1/IGF-1R signaling induces tumorassociated lymphangiogenesis and contributes to lymphatic metastasis of CRC. 关 键 词：Colorectal cancer INSULIN-LIKE GROWTH factor-1 INSULIN-LIKE GROWTH factor-1 receptor LYMPHANGIOGENESIS Lymphatic metastasis
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