Endothelial surface glycocalyx and vascular mechano-sensing and transduction

查看全文 作　　者：Wanyi [1]Yen;Jinlin [1]Yang;Min [1]Zeng;John [1]M.Tarbell;Bingmei [1]M.Fu 机构地区：[1]Department of Biomedical Engineering,the City College of the City University of New York 出　　处：《医用生物力学》索引2013年第28卷第S1期,共2页 基　　金：supported by NIH R01 HL094889-01 摘　　要：Introduction The endothelial cells(ECs)lining every blood vessel wall constantly expose to the mechanical forces generated by the blood flow.The EC responses to these hemodynamic forces play a critical role in the homeostasis of the circulatory system.In addition to forming a transport barrier between the blood and vessel wall,vascular ECs play important roles in regulating circulation functions.Besides biochemical stimuli,blood flow induced(hemodynamic)mechanical stimuli,such as shear stress,pressure and circumferential stretch,modulate EC morphology and functions by activating mechanosensors,signaling pathways,and gene and protein expressions.The EC responses to the hemodynamic forces(mechano-sensing and transduction) 关 键 词：TRANSDUCTION HEMODYNAMIC activating homeostasis constantly biochemical stimuli regulating STRETCH LINING