Value of a newly sequenced bacterial genome

查看全文 作　　者：Eudes GV [1,2]Barbosa;Flavia F [1,3]Aburjaile;Rommel TJ [4]Ramos;Adriana R [4]Carneiro;Yves Le [3]Loir;Jan [2]Baumbach;Anderson [1]Miyoshi;Artur [4]Silva;Vasco [1]Azevedo

机构地区：[1]Laboratório de Genética Celular e Molecular,Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 MG, Brazil;[2]Department of Mathematics and Computer Science, University of Southern Denmark,5230 Odense, Denmark;[3]INRA, UMR1253, Science et Technologie du Lait et de l’uf, F-35042 Rennes, France;[4]Laboratório de Polimorfismo de DNA, Instituto de Ciências Biológicas, Univeridade Federal do Pará, Belém 66075-110, Brazil

出　　处：《World Journal of Biological Chemistry》索引2014年第5卷第2期,共8页

基　　金：Supported by Coordenao de Aperfeioamento de Pessoal de Nível Superior(CAPES)in Brazil,processes BEX 12954-12-8 and 11517-12-3,to Barbosa EGV and Aburjaile FF 摘　　要：Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. 关键词：Next-generation sequencing DRAFTS PROKARYOTIC GENOMES Computational tools OMICS

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Value of a newly sequenced bacterial genome

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