Identifying the best therapy for chronic anal fissure

查看全文 作　　者：Mariusz H [1]Madalinski

机构地区：[1]NHS Lothian-University Hospitals Division,Edinburgh EH4 2XU,United Kingdom

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》索引2011年第2卷第2期,共8页

摘　　要：Chronic anal fissure(CAF)is a painful tear or crack which occurs in the anoderm.The optimal algorithm of therapy for CAF is still debated.Lateral internal sphincterotomy(LIS)is a surgical treatment,considered as the'gold standard'therapy for CAF.It relieves CAF symptoms with a high rate of healing.Chemical sphincterotomy(CS)with nitrates,calcium blockers or botulinum toxin(BTX)is safe,with the rapid relief of pain,mild sideeffects and no risk of surgery or anesthesia,but is a statistically less effective therapy for CAF than LIS.This article considers if aggressive treatment should only be offered to patients who fail pharmacological sphincterotomy.Aspects of anal fissure etiology,epidemiology and pathophysiology are considered with their meaning for further management of CAF.A molecular model of chemical interdependence significant for the chemistry of CAF healing is examined.Its application may influence the development of optimal therapy for CAF.BTX is currently considered the most effective type of CS and discussion in this article scrutinizes this method specifically.Although the effectiveness of BTXvs LIS has been discussed,the essential focus of the article concerns identifying the best therapy application for anal fissure.Elements are presented which may help us to predict CAF healing.They provide rationale for the expansion of the CAF therapy algorithm.Ethical and economic factors are also considered in brief.As long as the patient is willing to accept the potential risk of fecal incontinence,we have grounds for the'gold standard'(LIS)as the first-line treatment for CAF.The author concludes that,when the diagnosis of the anal fissure is established,CS should be considered for both ethical and economic reasons.He is convinced that a greater understanding and recognition of benign anal disorders by the GP and a proactive involvement at the point of initial diagnosis would facilitate the consideration of CS at an earlier,more practical stage with improved outcomes for the patient. 关键词：ANAL FISSURE BENIGN ANAL diseases Chemical SPHINCTEROTOMY BOTULINUM TOXIN Lateral internal SPHINCTEROTOMY Fissurectomy Ethics Teaching

相关文献

参考文献（3）
引证文献（6）
耦合文献（1）

参考文献(3)

引证文献(6)

耦合文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Identifying the best therapy for chronic anal fissure

参考文献(3)

引证文献(6)

耦合文献(1)

用户提示