Use of methotrexate in inflammatory bowel disease in 2014: A User's Guide

查看全文 作　　者：Arun [1,2]Swaminath;Raja [1]Taunk;Garrett [3]Lawlor

机构地区：[1]IBD Program,NorthShore Hospital System,Lenox Hill Hospital,New York,NY 10075,United States;[2]Division of Gastroenterology,Lenox Hill Hospital,New York,NY 10075,United States;[3]NY Harbor Veteran’s Affairs Healthcare system,Brooklyn Campus,Brooklyn,NY 11201,United States

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》索引2014年第5卷第3期,共9页

摘　　要：Methotrexate has been used an immunomodulator in many autoimmune diseases,including inflammatory bowel disease. However,many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios:(1) steroid dependant Crohn's disease(CD);(2) maintenance of remission in steroid free CD;(3) azathioprine failures in CD;(4) in combination therapy with Anti-TNF agents in CD;(5) decreasing antibody formation to Anti-TNF therapy in CD;(6) management of fistulizing disease in CD; and(7) as well as induction and maintenance of remission in ulcerative colitis. An easy to use algorithm is provided for the busy clinician to access and safely prescribe methotrexate for their inflammatory bowel disease patients. 关键词：METHOTREXATE Inflammatory bowel DISEASE Crohn’s DISEASE ULCERATIVE COLITIS IMMUNOMODULATORS METHOTREXATE user’s GUIDE

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Use of methotrexate in inflammatory bowel disease in 2014: A User's Guide

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