The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma(英文)

查看全文 作　　者：Linnebank [1]M;Schmidt [1]S;Kolsch [1]H;Linnebank [1]A;Heun [1]R;Schmidt-Wolf [1]IG;Glasmacher [1]A;Fliessbach [1]K;Klockgether [1]T;Schlegel [1]U;Pels [1]H 机构地区：[1]Department of Neurology, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn D-53125, Germany. 出　　处：《中国神经肿瘤杂志》索引2004年第2卷第2期,共1页 摘　　要：Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c. 2756A> G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homoeysteine and folate metabolism in lymphoma tumorigenesis. 关 键 词：甲硫氨酸合酶 D919G 基因多态性 遗传易感性 原发性中枢神经系统淋巴瘤