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Impact of cigarette smoking on response to interferon therapy in chronic hepatitis C Egyptian patients

查看全文 作　　者：A.EI-[1]Zayadi;Osaima [2]Selim;[1]H.Hamdy;A.EI-[3]Tawil;Hanaa [4]M.Badran;[5]M.Attia;[6]A.Saeed 高影响力作者 机构地区：[1]Departments of Tropical Medicine,Ain Shams University,Cairo,Egypt;[2]Department of Clinical Pathology,Ain Shams University,Cairo,Egypt;[3]Department of Pathology,Ain Shams University,Cairo,Egypt;[4]Department of Hepatology,National Liver Institute,Menoufeya,Egypt;[5]Department of Hepatology and Gastroenterology,Theodor Bilharz Research Institute,Cairo,Egypt;[6]Cairo Liver Center,Giza,Egypt高影响力机构 出　　处：《World Journal of Gastroenterology》索引2004年第10卷第20期,共4页高影响力期刊 摘　　要：AIM: Smoking may affect adversely the response rate to interferon-α. Our objective was to verify this issue among chronic hepatitis C patients. METHODS: Over the year 1998, 138 chronic hepatitis C male Egyptian patients presenting to Cairo Liver Center, were divided on the basis of smoking habit into: group I which comprised 38 smoker patients (>30 cigarettes/d) and group II which included 84 non-smoker patients. Irregular and mild smokers (16 patients) were excluded. Non eligible patients for interferon-~ therapy were excluded from the study and comprised 3/38 (normal ALT) in group I and 22/84 in group II (normal ALT, advanced cirrhosis and thrombocytopenia). Group I was randomly allocated into 2 sub-groups: group Ia comprised 18 patients who were subjected to therapeutic phlebotomy while sub-group Ib consisted of 17 patients who had no phlebotomy. In sub-group Ia, 3 patients with normal ALT after repeated phlebotomies were excluded from the study. Interferon-α2b 3 MU/TIW was given for 6 mo to 15 patients in group Ia, 17 patients in group Ib and 62 patients in group II. Biochemical, virological end-of- treatment and sustained responses were evaluated.RESULTS: At the end of interferon-α treatment, ALT was normalized in 3/15 patients (20%) in group Ia and 2/17 patients (11.8%) in group Ib compared to17/62 patients (27.4%) in group II (P=0.1). Whereas 2/15 patients (13.3%) in group Ia. and 2/17 patients (11.8%) in group Ib lost viraemia compared to 13/62 patients (26%) in group II(P=0.3). Six months later, ALT was persistently normal in 2/15 patients (13.3%) in group la and 1/17 patients (5.9%) in group Ib compared to 9/62 patients (14.5%) in group Ⅱ (P= 0.47). Viraemia was eliminated in 1/15 patients (6.7%) in group Ia and 1/17 patients (5.9%) in group Ib compared to 7/62 patients (11.3%) in group Ⅱ, but the results did not mount to statistical significance (P = 0.4). CONCLUSION: Smokers suffering from chronic hepatitis C tend to have a lower response rate to interferon-α compared to non-smokers. Therapeutic phlebotomy improves the response rate to interferon-α therapy among this group. 关 键 词：香烟 反应 干扰素 冲击 慢性丙型肝炎 HCV 埃及 肝脏
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