Inhibitory Effect of TCCE on CCl_4-induced Overexpression of IL-6 in Acute Liver Injury

查看全文 作　　者：JingGAO HuanDOU Xin-HuiTANG Li-ZhiXU Yi-MeiFAN Xiao-[1]NingZHAO

机构地区：[1]SchoolofMedicine,SchoolofLifeSciences,NanjingUniversity,Nanjing210093,China

出　　处：《Acta Biochimica et Biophysica Sinica》索引2004年第36卷第11期,共6页

摘　　要：Terminalia catappa L. leaves have been shown to protect against acute liver injury produced by some hepatotoxicants, but the active components and mechanisms are not clear. This study was designed to characterize the protective effects of the chloroform fraction of the ethanol extract of T. catappa leaves (TCCE) against carbon tetrachloride (CC14)-induced hepatotoxicity in mice, and analyze the changes in expression level of interleukin-6 (IL-6) in the process. It was found that TCCE pretreatment (10 or 30 mg/kg,ig) protected mice from CC14 toxicity, as evidenced by the reversed alterations in serum alanine aminotransferase (sALT) and serum aspartate aminotransferase (sAST) activities. Additionally liver tissues were subjected to RT-PCR, Western blot and immunohistochemistry to analyze changes in IL-6 expression. It was found that TCCE markedly suppressed the CC14-induced over-transcription ofIL-6 gene. Consistent with the result, the expression of IL-6 protein was also blocked by TCCE in CC14-stimulated mice, especially in the area around central vein on liver tissue section. In conclusion, TCCE is effective in protecting mice from the hepatotoxicity produced by CC14, and the mechanisms underlying its protective effects may be related to the inhibition on the overexpression of IL-6 mainly around terminal hepatic vein. 关键词：急性肝损伤表达四氯化碳榄仁树白细胞间介素-6

相关文献

参考文献（16）
引证文献（3）
耦合文献（5）

参考文献(16)

引证文献(3)

耦合文献(5)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Inhibitory Effect of TCCE on CCl_4-induced Overexpression of IL-6 in Acute Liver Injury

参考文献(16)

引证文献(3)

耦合文献(5)

用户提示