Clinical significance of serum IGF-I,IGF-II and IGFBP-3 in liver cirrhosis

查看全文 作　　者：Yun-LinWu JingYe ShuZhang JieZhong Rong-[1]PingXi

机构地区：[1]DepartmentofGastroenterology,RuijinHospital,ShanghaiSecondMedicalUniversity,Shanghai200025,China

出　　处：《World Journal of Gastroenterology》索引2004年第10卷第18期,共4页

基　　金：Supported by the Medical Development Project of Asahi Fund ofJapan 摘　　要：AIM: To investigate the relationship between insulin-like growth factor-Ⅰ, -Ⅱ (IGF-Ⅰ and IGF-Ⅱ), IGF-binding protein 3(IGFBP-3) and Child-Pugh score in patients with liver cirrhosis,and to search for potential clinical markers of liver function.METHODS: Forty-four patients with advanced liver cirrhosis of viral origin were divided into 3 groups according to severity of cirrhosis (Child-Pugh score) and 38 healthy subjects served as controls. Serum levels of IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 were measured by immunoradiometric assay.RESULTS: Serum IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 levels were significantly lower in patients with cirrhosis than in controls,and serum concentrations of IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 were associated with the severity of liver dysfunction, and dropped sharply during the progression of liver failure. Among these 3 parameters, serum IGF-Ⅱ was the most sensitive and effective indicator for liver dysfunction. Concentrations of IGF-Ⅰ <30 ng/mL, IGF-Ⅱ <200 ng/mL and IGFBP-3 <6 ng/mL implied a negative prognosis for patients with liver cirrhosis.CONCLUSION: Serum IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 may provide a new dimension in the assessment of liver dysfunction.Combined detection of serum IGF-Ⅰ, IGF-Ⅱ and IGFBP-3 with Child-Pugh score is more effective in predicting prognosis than Child-Pugh score alone. 关键词：临床作用免疫血清 IGF-Ⅰ IGF-Ⅱ IGFBP-3 肝硬化肝脏

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Clinical significance of serum IGF-I,IGF-II and IGFBP-3 in liver cirrhosis

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