Heparin improves organ microcirculatory disturbances in caerulein-induced acute pancreatitis in rats

查看全文 作　　者：Marek [1]Dobosz;Lucjanna [1]Mionskowska;Stanislaw Ha■[2];Sebastian [2]Dobrowolski;Dariusz [2]Dymecki;Zdzislaw [2]Wajda

机构地区：[1]Department of General and Gastroenterological Surgery,St.Vincent a'Paulo Hospital,Gdynia,Poland;[2]Department of General,Transplant and Endocrine Surgery,Medical University of Gda■sk,Poland

出　　处：《World Journal of Gastroenterology》索引2004年第10卷第17期,共4页

基　　金：Supported by Medical University of Gda■sk,grant W-120,Poland 摘　　要：AIM: Microcirculatory disturbances are important early pathophysiological events in various organs during acute pancreatitis. The aim of the study was to evaluate changes in rnicroperfusion of the pancreas, liver, kidney, stomach,colon, skeletal muscle, and to investigate the influence of heparin on the organ rnicrocirculation in caerulein-induced experimental acute pancreatitis.METHODS: Acute pancreatitis was induced by 4 intraperitoneal injections of caerulein (Cn) (15 μg/kg). The organ microcirculation was measured by laser Doppler flowrnetry. Serum interleukin 6 and hernatocrit levels were analysed.RESULTS: Acute pancreatitis resulted in a significant drop of microperfusion in all examined organs. Heparin administration (2×2.5 mg/kg) improved the rnicrocirculation in pancreas (36.9±4% vs75.9±10%), liver (56.6±6% vs 75.2±16%), kidney (45.1±6% vs79.3±5%), stomach (65.2±8% vs78.1±19%), colon (69.8±6% vs 102.5±19%),and skeletal muscle (59.2±6% vs 77.9±13%). Heparin treatment lowered IL-6 (359.0±66 U/mL vs 288.5±58 U/mL) and hematocrit level (53±4% vs 46±3%).CONCLUSION: Hepadn administration has a positive influence on organ microcirculatory disturbances accompanying experimental Cn-induced acute pancreatitis. 关键词：肝磷脂微观作用黄蛙素急性胰腺炎老鼠消化系统

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Heparin improves organ microcirculatory disturbances in caerulein-induced acute pancreatitis in rats

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耦合文献(98)

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