STUDY ON OBESITY RELATED FACTORS: FFA, LEPTIN AND ADIPONECTIN IN SUBJECTS WITH VARYING GLUCOSE TOLERANCE

查看全文 作　　者：[1]顾卫琼;[1]洪洁;[1]张翼飞;[1]宁光;[2]陈名道;[2]唐金凤 机构地区：[1]Shanghai Clinical Center of Endocrinology and Metabolism Diseases, Department of Endocrinology, Ruijin Hospital,Shanghai Second Medical University, Shanghai 200025, China;[2]Shanghai Institution of Endocrinology and Metabolism, Shanghai 200025, China 出　　处：《Journal of Shanghai Second Medical University(Foreign Language Edition)》索引2005年第17卷第1期,共5页 基　　金：Supported by IGT Intervention Program, Key Task of Shanghai Board of Health (01ZD002(2) ) . 摘　　要：Objective To study the fasting serum levels of obesity related factors: FFA, leptin and adi-ponectin in subjects with varying glucose tolerance and their relationship with BMI, insulin sensitivity index and isletbeta-cell function. Methods Serum levels of FFA, leptin and adiponectin in 24 normal, 32 simple obese, 34IGT and 36 T2DM subjects were measured by ACS-ACOD assay or RIA. Results The serum levels of leptin andFFA in three groups:simple obese, IGT and DM were much higher than those in normal control (P <0. 001). Incontrast, serum level of adiponectin of simple obese, IGT and DM groups were significant lower than that of normalcontrol, among them DM subjects had the lowest level (P <0. 001). Correlation analysis showed that FFA was pos-itively correlated to BMI, WHR, FBG, fasting insulin level and negatively correlated to SI; adiponectin was negativelycorrelated to BMI, WHR, FBG, PBG, but positively correlated to SI and AIRg; and leptin was positively correlated toBMI, fasting insulin and AIRg when negatively correlated to FBG and SI. None of them was correlated to age.Conclusion Subjects with insulin resistance have high serum FFA and leptin levels but low serum adiponectin level.With the glucose tolerance deterioration, serum FFA level increases much higher while the adiponectin deceases muchlower. Unlike insulin, none of these obesity related factors can be used as the simple indicating or determining factorof SI, though each of them, to different extent, takes part in the development of insulin resistance. 关 键 词：心肌肥厚 肥厚因素 FFA 己二腈 葡萄糖 心脏疾病