Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 in Human Meningiomas

查看全文 作　　者：[1]易伟;[1]陈坚;Filimon H. [1]Golwa;[1]薛德麟

机构地区：[1]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》索引2005年第25卷第1期,共3页

摘　　要：The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors’ histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. The tumors’ angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors’ histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas’ angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor. 关键词：碱性纤维原细胞生长因子纤维原细胞生长因子受体-1 脑膜瘤基因表达

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Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 in Human Meningiomas

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